Tudóstér: Virág László publikációi

Sturniolo, I., Váróczy, C., Regdon, Z., Türk-Mázló, A., Muzsai, S., Bácsi, A., Intili, G., Hegedűs, C., Boothby, M., Holechek, J., Ferraris, D., Schüler, H., Virág, L.: PARP14 contributes to the development of the tumor-associated macrophage phenotype.
Int. J. Mol. Sci. 25 (7), 1-21, 2024.

Sturniolo, I., Váróczy, C., Bede, Á., Hegedűs, C., Demény, M., Virág, L.: Quantifying antibody-dependent cellular cytotoxicity in a tumor spheroid model: application for drug discovery.
J. Vis. Exp. [Epub ahead of print]2024.

Skopál, A., Ujlaki, G., Gerencsér, A., Bankó, C., Bacsó, Z., Ciruela, F., Virág, L., Haskó, G., Kókai, E.: Adenosine A2A Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages.
Curr. Issues Mol. Biol. 45 (6), 4948-4969, 2023.

Guti, E., Bede, Á., Váróczy, C., Hegedűs, C., Demény, M., Virág, L.: High-Content Screening Assay for the Identification of Antibody-Dependent Cellular Cytotoxicity Modifying Compounds.
JoVE. 198 1-12, 2023.

Virág, L.: 100 éves a Debreceni Egyetem Orvosi Vegytani Intézete.
Gerundium. 8 (1-2), 203-216, 2022.

Skopál, A., Kéki, T., Tóth, P., Csóka, B., Koscsó, B., Németh, Z., Antonioli, L., Ivessa, A., Ciruela, F., Virág, L., Haskó, G., Kókai, E.: Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling.
J. Biol. Chem. 298 (5), 1-18, 2022.

Hajnády, Z., Nagy-Pénzes, M., Demény, M., Kovács, K., El-Hamoly, T., Maléth, J., Hegyi, P., Polgár, Z., Hegedűs, C., Virág, L.: OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis.
Biomedicines. 10 (10), 1-17, 2022.

Guti, E., Regdon, Z., Sturniolo, I., Kiss, A., Kovács, K., Demény, M., Szöőr, Á., Vereb, G., Szöllősi, J., Hegedűs, C., Polgár, Z., Virág, L.: The multitargeted receptor tyrosine kinase inhibitor sunitinib induces resistance of HER2 positive breast cancer cells to trastuzumab-mediated ADCC.
Cancer Immunol. Immunother. 71 (9), 2151-2168, 2022.

Nagy-Pénzes, M., Hajnády, Z., Regdon, Z., Demény, M., Kovács, K., El-Hamoly, T., Maléth, J., Hegyi, P., Hegedűs, C., Virág, L.: Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: the Role of Oxidative Stress-Induced DNA Damage Signaling.
Biomedicines. 10 (6), 1-20, 2022.

Torma, F., Bakonyi, P., Regdon, Z., Gombos, Z., Jókai, M., Babszki, G., Fridvalszki, M., Virág, L., Naito, H., Iftikhar Bukhari, S., Radák, Z.: Blood flow restriction during the resting periods of high-intensity resistance training does not alter performance but decreases MIR-1 and MIR-133A levels in human skeletal muscle.
Sports Medicine and Health Science. 3 (1), 40-45, 2021.

Molnár, T., Pallagi, P., Tél, B., Király, R., Csoma, E., Jenei, V., Varga, Z., Gogolák, P., Odile Hueber, A., Máté, Z., Erdélyi, F., Szabó, G., Pettkó-Szandtner, A., Bácsi, A., Virág, L., Maléth, J., Koncz, G.: Caspase-9 acts as a regulator of necroptotic cell death.
FEBS J. 288 (22), 6476-6491, 2021.

Regdon, Z., Demény, M., Kovács, K., Hajnády, Z., Nagy-Pénzes, M., Bakondi, E., Kiss, A., Hegedűs, C., Virág, L.: High-Content Screening identifies inhibitors of oxidative stress-induced parthanatos: cytoprotective and anti-inflammatory effects of ciclopirox.
Br. J. Pharmacol. 178 (5), 1095-1113, 2021.

Horváth, B., Khan, M., Hézső, T., Dienes, C., Kovács, Z., Kiss, D., Prorok, J., Árpádffy-Lovas, T., Varga, R., Fujii, E., Topal, L., Kistamás, K., Varró, A., Virág, L.: Is selective late sodium current inhibition different from class I/B antiarrhythmic action? Comparison of the effects of GS967 to mexiletine in canine ventricular myocardium.
Europace. 23 (Supplement), iii622, 2021.

Kiss, A., Csíkos, C., Regdon, Z., Polgár, Z., Virág, L., Hegedűs, C.: NMNAT1 Is a Survival Factor in Actinomycin D-Induced Osteosarcoma Cell Death.
Int. J. Mol. Sci. 22 (16), 1-17, 2021.

El-Hamoly, T., Hajnády, Z., Nagy-Pénzes, M., Bakondi, E., Regdon, Z., Demény, M., Kovács, K., Hegedűs, C., Abd El-Rahman, S., Szabó, É., Maléth, J., Hegyi, P., Virág, L.: Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis.
Int. J. Mol. Sci. 22 (7), 1-15, 2021.

Demény, M., Virág, L.: The PARP enzyme family and the hallmarks of cancer. Part 1. Cell intrinsic hallmarks.
Cancers (Basel). 13 1-28, 2021.

Demény, M., Virág, L.: The PARP enzyme family and the hallmarks of cancer. Part 2. Hallmarks related to cancer host interactions.
Cancers (Basel). 13 1-21, 2021.

Lontay, B., Kiss, A., Virág, L., Tar, K.: How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review.
Int. J. Mol. Sci. 21 (12), 1-34, 2020.

Kiss, B., Szántó, M., Hegedűs, C., Antal, D., Szödényi, A., Márton, J., Méhes, G., Virág, L., Szegedi, A., Bai, P.: Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis.
Exp. Dermatol. 29 (1), 79-85, 2020.

Kiss, A., Ráduly, A., Regdon, Z., Polgár, Z., Tarapcsák, S., Sturniolo, I., El-Hamoly, T., Virág, L., Hegedűs, C.: Targeting nuclear NAD+ synthesis inhibits DNA repair, impairs metabolic adaptation increases chemosensitivity of U-2OS osteosarcoma cells.
Cancers (Basel). 12 (5), 1-27, 2020.

Douida, A., Batista, F., Robaszkiewicz, A., Botó, P., Aladdin, A., Szenykiv, M., Czinege, R., Virág, L., Tar, K.: The proteasome activator PA200 regulates expression of genes involved in cell survival upon selective mitochondrial inhibition in neuroblastoma cells.
J. Cell. Mol. Med. 24 (12), 6716-6730, 2020.

Kovács, P., Csonka, T., Kovács, T., Sári, Z., Ujlaki, G., Sipos, A., Karányi, Z., Szeőcs, D., Hegedűs, C., Uray, K., Jankó, L., Kiss, M., Kiss, B., Laoui, D., Virág, L., Méhes, G., Bai, P., Mikó, E.: Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer.
Cancers (Basel). 11 1-31, 2019.

Regdon, Z., Robaszkiewicz, A., Kovács, K., Rygielska, Ż., Hegedűs, C., Bodoor, K., Szabó, É., Virág, L.: LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis.
Free Radic. Biol. Med. 131 184-196, 2019.

Tokarz, P., Poszaj, T., Regdon, Z., Virág, L., Robaszkiewicz, A.: PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition.
Free Radic. Biol. Med. 131 218-224, 2019.

Robinson, N., Ganesan, R., Hegedűs, C., Kovács, K., Kufer, T., Virág, L.: Programmed necrotic cell death of macrophages: Focus on pyroptosis, necroptosis, and parthanatos.
Redox Biol. 26 1-8, 2019.

Virág, L., Jaén, R., Regdon, Z., Boscá, L., Prieto, P.: Self-defense of macrophages against oxidative injury: fighting for their own survival.
Redox Biol. 26 1-9, 2019.

Bakondi, E., Singh, S., Hajnády, Z., Nagy-Pénzes, M., Regdon, Z., Kovács, K., Hegedűs, C., Madácsy, T., Maléth, J., Hegyi, P., Demény, M., Nagy, T., Kéki, S., Szabó, É., Virág, L.: Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis.
Int. J. Mol. Sci. 20 (17), 1-18, 2019.

Hegedűs, C., Kovács, K., Lakatos, P., Virág, L.: A poli(ADP-ribóz) polimerázok (PARP): fókuszban a PARP-1.
In: Ezerarcú fehérjék. Szerk.: Buday László, Nyitray László, Perczel András, Semmelweis Kiadó, 2018, 775-786, 2018. ISBN: 9789633314586

Hrubi, E., Imre, L., Robaszkiewicz, A., Virág, L., Kerényi, F., Nagy, K., Varga, G., Jenei, A., Hegedűs, C.: Diverse effect of BMP-2 homodimer on mesenchymal progenitors of different origin.
Hum. Cell. 31 (2), 139-148, 2018.

Tempka, D., Tokarz, P., Chmielewska, K., Kluska, M., Pietrzak, J., Rygielska, Ż., Virág, L., Robaszkiewicz, A.: Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair.
Redox Biol. 15 316-326, 2018.

Robaszkiewicz, A., Wisnik, E., Regdon, Z., Chmielewska, K., Virág, L.: PARP1 facilitates EP300 recruitment to the promoters of the subset of RBL2-dependent genes.
Biochim. Biophys. Acta. Gene Regul. Mech. 1861 (1), 41-53, 2018.

Pietrzak, J., Spickett, C., Płoszaj, T., Virág, L., Robaszkiewicz, A.: PARP1 promoter links cell cycle progression with adaptation to oxidative environment.
Redox Biol. 18 1-5, 2018.

Hegedűs, C., Kovács, K., Polgár, Z., Regdon, Z., Szabó, É., Robaszkiewicz, A., Forman, H., Martner, A., Virág, L.: Redox control of cancer cell destruction.
Redox Biol. 16 59-74, 2018.

Bodnár, E., Bakondi, E., Kovács, K., Hegedűs, C., Lakatos, P., Robaszkiewicz, A., Regdon, Z., Virág, L., Szabó, É.: Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds.
Oxid. Med. Cell. Longev. 2018 1-12, 2018.

Csóka, B., Törő, G., Vindeirinho, J., Varga, Z., Koscsó, B., Németh, Z., Kókai, E., Antonioli, L., Suleiman, M., Marchetti, P., Cseri, K., Deák, Á., Virág, L., Pacher, P., Bai, P., Haskó, G.: A2A adenosine receptors control pancreatic dysfunction in high-fat-diet induced obesity.
Faseb J. 31 (11), 4985-4997, 2017.

Virág, L.: A sokarcú sejthalál és a PARP1 karrierje: a védőenzim is árthat.
Élet Tud. 25 777-779, 2016.

Rodriguez-Vargas, J., Rodríguez, M., Majuelos-Melguizo, J., García-Diaz, Á., González-Flores, A., López-Rivas, A., Virág, L., Illuzzi, G., Schreiber, V., Dantzer, F., Oliver, F.: Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export.
Cell Death Differ. 23 (12), 2007-2018, 2016.

Géhl, Z., Bakondi, E., Resch, M., Hegedűs, C., Kovács, K., Lakatos, P., Szabó, A., Nagy, Z., Virág, L.: Diabetes-induced oxidative stress in the vitreous humor.
Redox Biology. 9 100-103, 2016.

Brunyánszki, A., Szczesny, B., Virág, L., Szabó, C.: Mitochondrial poly(ADP-ribose) polymerase: the Wizard of Oz at work.
Free Radic. Biol. Med. 100 257-270, 2016.

Virág, L.: Szabad gyökökről.
Debr. szle. 24 (2), 144-153, 2016.

Lakatos, P., Hegedűs, C., Salazar Ayestarán, N., Juarranz, Á., Kövér, K., Szabó, É., Virág, L.: The PARP inhibitor PJ-34 sensitizes cells to UVA-induced phototoxicity by a PARP independent mechanism.
Mutat. Res.-Fundam. Mol. Mech. Mutagen. 790 31-40, 2016.

Gergely, S., Hegedűs, C., Lakatos, P., Kovács, K., Gáspár, R., Csont, T., Virág, L.: High throughput screening identifies a novel compound protecting cardiomyocytes from doxorubicin-induced damage.
Oxid. Med. Cell. Longev. 2015 1-12, 2015.

Kiss, B., Szántó, M., Szklenár, M., Brunyánszki, A., Marosvölgyi, T., Sárosi, E., Remenyik, É., Gergely, P., Virág, L., Decsi, T., Rühl, R., Bai, P.: Poly(ADP) ribose polymerase-1 ablation alters eicosanoid and docosanoid signaling and metabolism in a murine model of contact hypersensitivity.
Mol. Med. Rep. 11 (4), 2861-2867, 2015.

Hegedűs, C., Robaszkiewicz, A., Lakatos, P., Szabó, É., Virág, L.: Poly(ADP-ribose) in the bone: from oxidative stress signal to structural element.
Free Radic. Biol. Med. 82 179-186, 2015.

Dedinszki, D., Sipos, A., Kiss, A., Bátori, R., Kónya, Z., Virág, L., Erdődi, F., Lontay, B.: Protein phosphatase-1 is involved in the maintenance of normal homeostasis and in UVA irradiation-induced pathological alterations in HaCaT cells and in mouse skin.
Biochim. Biophys. Acta. Mol. Basis Dis. 1852 (1), 22-33, 2015.

Csóka, B., Koscsó, B., Törő, G., Kókai, E., Virág, L., Németh, Z., Pacher, P., Bai, P., Haskó, G.: A2B Adenosine Receptors Prevent Insulin Resistance by Inhibiting Adipose Tissue Inflammation via Maintaining Alternative Macrophage Activation.
Diabetes. 63 (3), 850-866, 2014.

El-Hamoly, T., Hegedűs, C., Lakatos, P., Kovács, K., Bai, P., El-Ghazaly, M., El-Denshary, E., Szabó, É., Virág, L.: Activation of poly(ADP-ribose) polymerase-1 delays wound healing by regulating keratinocyte migration and production of inflammatory mediators.
Mol. Med. 20 363-371, 2014.

Paragh, L., Virág, L., Sawhney, I., Remenyik, É., Szabó, É.: A diabétesz-láb pathogenesise, kezelési lehetőségei, a megelőzés jelentősége = The pathogenesis of diabetic foot syndrome, the importance of prevention and further therapeutic possibilities.
Bőrgyógyász. Venerol. Szle. 90 (3), 115-121, 2014.

Szántó, M., Brunyánszki, A., Márton, J., Vámosi, G., Nagy, L., Fodor, T., Kiss, B., Virág, L., Gergely, P., Bai, P.: Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels.
Biochim. Biophys. Acta. Mol. Basis Dis. 1842 (4), 594-602, 2014.

Hegedűs, C., Virág, L.: Inputs and outputs of poly(ADP-ribosyl)ation: relevance to oxidative stress.
Redox Biology. 2 978-982, 2014.

Robaszkiewicz, A., Valkó, Z., Kovács, K., Hegedűs, C., Bakondi, E., Bai, P., Virág, L.: The role of p38 signaling and poly(ADP-ribosyl)ation-induced metabolic collapse in the osteogenic differentiation-coupled cell death pathway.
Free Radic. Biol. Med. 76C 69-79, 2014.

Lakatos, P., Szabó, É., Hegedűs, C., Haskó, G., Gergely, P., Bai, P., Virág, L.: 3-Aminobenzamide protects primary human keratinocytes from UV-induced cell death by a poly(ADP-ribosyl)ation independent mechanism.
Biochim. Biophys. Acta. Mol. Cell Res. 1833 (3), 743-751, 2013.

Virág, L.: 50Years of poly(ADP-ribosyl)ation.
Mol. Asp. Med. 34 (6), 1043-1045, 2013.

Koscsó, B., Csóka, B., Kókai, E., Németh, H., Pacher, P., Virág, L., Leibovich, J., Haskó, G.: Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages.
J. Leukoc. Biol. 94 (6), 1309-1315, 2013.

Hegedűs, C., Lakatos, P., Kiss-Szikszai, A., Patonay, T., Gergely, S., Gregus, A., Bai, P., Haskó, G., Szabó, É., Virág, L.: Cytoprotective dibenzoylmethane derivatives protect cells from oxidative stress-induced necrotic cell death.
Pharmacol. Res. 72 25-34, 2013.

Nagy, L., Docsa, T., Szántó, M., Brunyánszki, A., Hegedűs, C., Márton, J., Kónya, B., Virág, L., Somsák, L., Gergely, P., Bai, P.: Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N'-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism.
PLoS One. 8 (7), e69420-, 2013.

Oit, -., Virág, L., Soomets, U., Altraja, A.: Increased DNA Damage in Progression Of COPD: A Response By Poly(ADP-Ribose) Polymerase-1.
PLoS One. 8 (7), e70333-, 2013.

Palicz, Z., Jenes, Á., Gáll, T., Miszti-Blasius, K., Kollár, S., Kovács, I., Emri, M., Márián, T., Leiter, É., Pócsi, I., Csősz, É., Kalló, G., Hegedűs, C., Virág, L., Csernoch, L., Szentesi, P.: In vivo application of a small molecular weight antifungal protein of Penicillium chrysogenum (PAF).
Toxicol. Appl. Pharmacol. 269 (1), 8-16, 2013.

Bürkle, A., Virág, L.: Poly(ADP-ribose): PARadigms and PARadoxes.
Mol. Asp. Med. 34 (6), 1046-1065, 2013.

Virág, L., Robaszkiewicz, A., Rodriguez-Vargas, J., Oliver, F.: Poly(ADP-ribose) signaling in cell death.
Mol. Asp. Med. 34 (6), 1153-1167, 2013.

Erdélyi, K., Pacher, P., Virág, L., Szabó, C.: Role of poly(ADP-ribosyl)ation in a 'two-hit' model of hypoxia and oxidative stress in human A549 epithelial cells in vitro.
Int. J. Mol. Med. 32 (2), 339-346, 2013.

Koscsó, B., Csóka, B., Selmeczy, Z., Himer, L., Pacher, P., Virág, L., Haskó, G.: Adenosine Augments IL-10 Production by Microglial Cells through an A2B Adenosine Receptor-Mediated Process.
J. Immunol. 188 (1), 445-453, 2012.

Robaszkiewicz, A., Erdélyi, K., Kovács, K., Kovács, I., Bai, P., Rajnavölgyi, É., Virág, L.: Hydrogen peroxide-induced poly(ADP-ribosyl)ation regulates osteogenic differentiation-associated cell death.
Free Radic. Biol. Med. 53 (8), 1552-1564, 2012.

Géhl, Z., Bai, P., Bodnár, E., Emri, G., Remenyik, É., Németh, J., Gergely, P., Virág, L., Szabó, É.: Poly(ADP-ribose) in the skin and in malignant melanomas.
Histol. Histopath. 27 651-659, 2012.

Szántó, M., Brunyánszki, A., Kiss, B., Nagy, L., Gergely, P., Virág, L., Bai, P.: Poly(ADP-ribose) polymerase-2: emerging transcriptional roles of a DNA-repair protein.
Cell. Mol. Life Sci. 69 (24), 4079-4092, 2012.

Kovács, K., Erdélyi, K., Hegedűs, C., Lakatos, P., Regdon, Z., Bai, P., Haskó, G., Szabó, É., Virág, L.: Poly(ADP-ribosyl)ation is a survival mechanism in cigarette smoke-induced and hydrogen peroxide-mediated cell death.
Free Radic. Biol. Med. 53 (9), 1680-1688, 2012.

Bai, P., Virág, L.: Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes.
FEBS Lett. 586 (21), 3771-3777, 2012.

Haskó, G., Csóka, B., Koscsó, B., Chandra, R., Pacher, P., Thompson, L., Deitch, E., Spolarics, Z., Virág, L., Gergely, P., Rolandelli, R., Németh, Z.: Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis.
J. Immunol. 187 (8), 4256-4267, 2011.

Szabó, É., Kovács, I., Grune, T., Haczku, A., Virág, L.: PARP-1: a new player in the asthma field?.
Allergy. 66 (7), 811-814, 2011.

Szántó, M., Rutkai, I., Hegedűs, C., Czikora, Á., Rózsahegyi, M., Kiss, B., Virág, L., Gergely, P., Tóth, A., Bai, P.: Poly(ADP-ribose) polymerase-2 depletion reduces doxorubicin-induced damage through SIRT1 induction.
Cardiovasc. Res. 92 (3), 430-438, 2011.

Erdélyi, K., Virág, L.: A poli(ADP-ribozil)áció szerepének vizsgálata tüdőepitélsejtek gyulladásos kemokin- és citokinexpressziójában, illetve sejthalálban.
Biokémia. 34 (4), 7-15, 2010.

Brunyánszki, A., Hegedűs, C., Szántó, M., Erdélyi, K., Kovács, K., Schreiber, V., Gergely, S., Kiss, B., Szabó, É., Virág, L., Bai, P.: Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress.
J. Invest. Dermatol. 130 (11), 2629-2637, 2010.

Erdélyi, K., Bai, P., Kovács, I., Szabó, É., Mocsár, G., Kakuk, A., Szabó, C., Gergely, P., Virág, L.: Dual role of poly(ADP-ribose) glycohydrolase in the regulation of cell death in oxidatively stressed A549 cells.
FASEB J. 23 (10), 3553-3563, 2009.

Bai, P., Hegedűs, C., Szabó, É., Gyüre, L., Bakondi, E., Brunyánszki, A., Gergely, S., Szabó, C., Virág, L.: Poly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity.
J. Invest. Dermatol. 129 (1), 234-238, 2009.

Géhl, Z., Németh, J., Virág, L.: Peroxinitrit-képződés és poli(ADP-ribóz) polimeráz aktiváció a szemben.
Szemészet. 145 (3-4), 75-81, 2008.

Hegedűs, C., Lakatos, P., Oláh, G., Tóth, I., Gergely, S., Szabó, É., Bíró, T., Szabó, C., Virág, L.: Protein kinase C protects from DNA damage-induced necrotic cell death by inhibiting poly(ADP-ribose) polymerase-1.
FEBS Lett. 582 (12), 1672-1678, 2008.

Csóka, B., Németh, H., Virág, L., Gergely, P., Leibovich, J., Pacher, P., Sun, C., Blackburn, R., Vizi, S., Deitch, E., Haskó, G.: A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli.
Blood. 110 (7), 2685-2695, 2007.

Zákány, R., Bakondi, E., Juhász, T., Matta, C., Szíjgyártó, Z., Erdélyi, K., Szabó, É., Módis, L., Virág, L., Gergely, P.: Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes.
Int. J. Mol. Med. 19 (4), 597-605, 2007.

Bai, P., Hegedűs, C., Erdélyi, K., Szabó, É., Bakondi, E., Gergely, S., Szabó, C., Virág, L.: Protein tyrosine nitration and poly(ADP-ribose) polymerase activation in N-methyl-N-nitrosoguanidine-treated thymocytes: implication for cytotoxicity.
Toxicol. Lett. 170 (3), 203-213, 2007.

Szabó, É., Erdélyi, K., Hegedűs, C., Kovács, I., Virág, L.: Role of poly(ADP-ribosyl)ation in oxidative stress-induced pathologies.
In: Reactive Oxygen Species and Diseases. Ed.: László Góth, Research Signpost, Kerala, India, 1-18, 2007.

Virág, L.: PARP-1 and the shape of cell death.
In: Poly(ADP-ribosyl)ation. Eds.: Alexander Bürkle, Landes Bioscience, USA, 141-152, 2006.

Erdélyi, K., Kiss, A., Bakondi, E., Bai, P., Szabó, C., Gergely, P., Erdődi, F., Virág, L.: Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells.
Mol. Pharmacol. 68 (3), 895-904, 2005.

Erdélyi, K., Bakondi, E., Gergely, P., Szabó, C., Virág, L.: Pathophysiologic role of oxidative stress-induced poly(ADP-ribose) polymerase-1 activation: focus on cell death and transcriptional regulation.
Cell. Mol. Life Sci. 62 (7-8), 751-759, 2005.

Borbély, A., Tóth, A., Édes, I., Virág, L., Papp, G., Varró, A., Paulus, W., Velden, J., Stienen, G., Papp, Z.: Peroxynitrite-induced alpha-actinin nitration and contractile alterations in isolated human myocardial cells.
Cardiovasc. Res. 67 (2), 225-233, 2005.

Virág, L.: Poly(ADP-ribosyl)ation in asthma and other lung diseases.
Pharmacol. Res. 52 (1), 83-92, 2005.

Virág, L.: Structure and function of poly(ADP-ribose) polymerase-1: role in oxidative stress-related pathologies.
Curr. Vasc. Pharmacol. 3 (3), 209-214, 2005.

Virág, L.: The expanding universe of poly(ADP-ribosyl)ation.
Cell. Mol. Life Sci. 62 (7-8), 719-720, 2005.

Bakondi, E., Bai, P., Erdélyi, K., Szabó, C., Gergely, P., Virág, L.: Cytoprotective effect of gallotannin in oxidatively stressed HaCaT keratinocytes: the role of poly(ADP-ribose) metabolism.
Exp. Dermatol. 13 (3), 170-178, 2004.

Virág, L., Bai, P., Bak, I., Pacher, P., Mabley, J., Liaudet, L., Bakondi, E., Gergely, P., Kollai, M., Szabó, C.: Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma.
Med. Sci. Monit. 10 (3), BR77-83, 2004.

Bai, P., Mabley, J., Liaudet, L., Virág, L., Szabó, C., Pacher, P.: Matrix metalloproteinase activation is an early event in doxorubicin-induced cardiotoxicity.
Oncol. Rep. 11 (2), 505-508, 2004.

Komjáti, K., Mabley, J., Virág, L., Southan, G., Salzman, A., Szabó, C.: Poly(ADP-ribose) polymerase inhibition protect neurons and the white matter and regulates the translocation of apoptosis-inducing factor in stroke.
Int. J. Mol. Med. 13 (3), 373-382, 2004.

Mabley, J., Pacher, P., Bai, P., Wallace, R., Goonesekera, S., Virág, L., Southan, G., Szabó, C.: Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.
Mutat. Res. 548 (1-2), 107-116, 2004.

Németh, Z., Leibovich, J., Deitch, E., Sperlágh, B., Virág, L., Vizi, S., Szabó, C., Haskó, G.: Adenosine stimulates CREB activation in macrophages via a p38 MAPK-mediated mechanism.
Biochem. Biophys. Res. Commun. 312 (4), 883-888, 2003.

Liaudet, L., Szabó, C., Evgenov, O., Murthy, K., Pacher, P., Virág, L., Mabley, J., Marton, A., Soriano, F., Kirov, M., Bjertnaes, L., Salzman, A.: Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis.
Shock. 19 (2), 131-137, 2003.

Virág, L., Szabó, É., Gergely, P., Szabó, C.: Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention.
Toxicol. Lett. 140-141 113-124, 2003.

Scott, G., Virág, L., Szabó, C., Hooper, D.: Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation.
Glia. 41 (2), 105-116, 2003.

Pacher, P., Liaudet, L., Bai, P., Mabley, J., Kaminski, P., Virág, L., Deb, A., Szabó, É., Ungvári, Z., Wolin, M., Groves, J., Szabó, C.: Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction.
Circulation. 107 (6), 896-904, 2003.

Bakondi, E., Gönczi, M., Szabó, É., Bai, P., Pacher, P., Gergely, P., Kovács, L., Hunyadi, J., Szabó, C., Csernoch, L., Virág, L.: Role of Intracellular Calcium Mobilization and Cell-Density-Dependent Signaling in Oxidative-Stress-Induced Cytotoxicity in HaCaT Keratinocytes.
J. Invest. Dermatol. 121 (1), 88-95, 2003.

Liaudet, L., Pacher, P., Mabley, J., Virág, L., Soriano, F., Haskó, G., Szabó, C.: Activation of poly(ADP-Ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation.
Am. J. Respir. Crit. Care Med. 165 (3), 372-377, 2002.

Pacher, P., Liaudet, L., Bai, P., Virág, L., Mabley, J., Haskó, G., Szabó, C.: Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.
J. Pharmacol. Exp. Ther. 300 (3), 862-867, 2002.

Kirov, M., Evgenov, O., Kuklin, V., Virág, L., Pacher, P., Southan, G., Salzman, A., Szabó, C., Bjertnaes, L.: Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep.
Am. J. Respir. Crit. Care Med. 166 (11), 1436-1442, 2002.

Szabó, C., Virág, L.: Cell-based assay for detecting activation of poly (ADP-ribose) polymerase.
[szabadalom]

Ohshima, H., Virág, L., Souza, H., Yermilov, V., Pignatelli, B., Masuda, M., Szabó, C.: Detection of certain peroxynitrite-induced DNA modifications.
In: Methods in molecular biology. Vol. 186 : Oxidative stress and antioxidant protocols. Eds.: Armstrong D, Humana Press, -Totowa, New Jersey, 77-88, 2002.

Lorch, S., Lightfoot, R., Ohshima, H., Virág, L., Chen, Q., Hertkorn, C., Weiss, M., Souza, J., Ischiropoulos, H., Yermilov, V., Pignatelli, B., Masuda, M., Szabó, C.: Detection of peroxynitrite-induced protein and DNA modifications.
In: Methods in Molecular Biology. Vol 196.. Eds.: Armstrong D, Humana Press, Totowa, New Jersey, 247-275, 2002.

Bakondi, E., Bai, P., Szabó, É., Hunyadi, J., Gergely, P., Szabó, C., Virág, L.: Detection of poly(ADP-ribose) polymerase activation in oxidatively stressed cells and tissues using biotinylated NAD substrate.
J. Histochem. Cytochem. 50 (1), 91-98, 2002.

Liaudet, L., Mabley, J., Pacher, P., Virág, L., Soriano, F., Marton, A., Haskó, G., Deitch, E., Szabó, C.: Inosine exerts a broad range of antiinflammatory effects in a murine model of acute lung injury.
Ann. Surg. 235 (4), 568-578, 2002.

Faro, R., Toyoda, Y., McCully, J., Jagtap, P., Szabó, É., Virág, L., Bianchi, C., Levitsky, S., Szabó, C., Sellke, F.: Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor.
Ann. Thorac. Surg. 73 (2), 575-581, 2002.

Virág, L., Szabó, É., Bakondi, E., Bai, P., Gergely, P., Hunyadi, J., Szabó, C.: Nitric oxide-peroxynitrite-poly(ADP-ribose) polymerase pathway in the skin.
Exp. Dermatol. 11 (3), 189-202, 2002.

Jagtap, P., Soriano, F., Virág, L., Liaudet, L., Mabley, J., Szabó, É., Haskó, G., Marton, A., Lorigados, C., Gallyas, F., Sümegi, B., Hoyt, D., Baloglu, E., VanDuzer, J., Salzman, A., Southan, G., Szabó, C.: Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
Crit. Care. Med. 30 (5), 1071-1082, 2002.

Szabó, C., Mabley, J., Moeller, S., Shimanovich, R., Pacher, P., Virág, L., Soriano, F., Van Duzer, J., Williams, W., Salzman, A., Groves, J.: Part I: pathogenetic role of peroxynitrite in the development of diabetes and diabetic vascular complications : studies with FP15, a novel potent peroxynitrite decomposition catalyst.
Mol. Med. 8 (10), 571-580, 2002.

Goldfarb, R., Marton, A., Szabó, É., Virág, L., Salzman, A., Glock, D., Akhter, I., McCarthy, R., Parrillo, J., Szabó, C.: Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.
Crit. Care. Med. 30 (5), 974-980, 2002.

Soriano, F., Liaudet, L., Szabó, É., Virág, L., Mabley, J., Pacher, P., Szabó, C.: Resistance to acute septic peritonitis in poly(ADP-ribose) polymerase-1-deficient mice.
Shock. 17 (4), 286-292, 2002.

Mabley, J., Virág, L., Szabó, C.: Role of poly(ADP-ribose) polymerase in the pathogenesis of Diabetes Mellitus and diabetic vascular pysfunction.
In: PARP as a therapeutic target. Eds.: Jie Zhang, CRC Press, Boca Raton, Florida, 277-319, 2002.

Virág, L., Szabó, C.: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors.
Pharmacol. Rev. 54 (3), 375-429, 2002.

Mabley, J., Jagtap, P., Perretti, M., Getting, S., Salzman, A., Virág, L., Szabó, É., Soriano, F., Liaudet, L., Abdelkarim, G., Haskó, G., Marton, A., Southan, G., Szabó, C.: Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.
Inflamm. Res. 50 (11), 561-569, 2001.

Soriano, F., Virág, L., Szabó, C.: Diabetic endothelial dysfunction: role of reactive oxygen and nitrogen species production and poly(ADP-ribose) polymerase activation.
J. Mol. Med. 79 (8), 437-448, 2001.

Soriano, F., Virág, L., Jagtap, P., Szabó, É., Mabley, J., Liaudet, L., Marton, A., Hoyt, D., Murthy, K., Salzman, A., Southan, G., Szabó, C.: Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.
Nat. Med. 7 (1), 108-113, 2001.

Lohinai, Z., Stachlewitz, R., Virág, L., Székely, A., Haskó, G., Szabó, C.: Evidence for reactive nitrogen species formation in the gingivomucosal tissue.
J. Dent. Res. 80 (2), 470-475, 2001.

Eaves-Pyles, T., Murthy, K., Liaudet, L., Virág, L., Ross, G., Soriano, F., Szabó, C., Salzman, A.: Flagellin, a novel mediator of Salmonella-induced epithelial activation and systemic inflammation: I kappa B alpha degradation, induction of nitric oxide synthase, induction of proinflammatory mediators, and cardiovascular dysfunction.
J. Immunol. 166 (2), 1248-1260, 2001.

Mabley, J., Liaudet, L., Soriano, F., Virág, L., Jagtap, P., Marton, A., Lorigados, C., Gallyas, F., Szabó, E., Abdulkarim, G., Haskó, G., Southan, G., Salzman, A., Szabó, C.: Local and systemic inflammation: role of poly(ADP-ribose) synthetase activation by reactive nitrogen species.
In: Nitric oxide and inflammation. Eds.: Salvemini D., Billiar T., Vodovotz Y, Birkhauser Verlag, Basel, Switzerland, , 2001.

Bai, P., Bakondi, E., Szabó, É., Gergely, P., Szabó, C., Virág, L.: Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes.
Free Radic. Biol. Med. 31 (12), 1616-1623, 2001.

Szabó, É., Virág, L., Bakondi, E., Gyüre, L., Haskó, G., Bai, P., Hunyadi, J., Gergely, P., Szabó, C.: Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity.
J. Invest. Dermatol. 117 (1), 74-80, 2001.

Virág, L., Szabó, C.: Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death.
Faseb J. 15 (1), 99-107, 2001.

Soejima, K., Traber, L., Scghmalstieg, F., Hawkins, H., Jodoin, J., Szabó, C., Szabó, É., Virág, L., Salzman, A., Traber, D.: Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury.
Am. J. Respir. Crit. Care Med. 163 (3), 745-752, 2001.

Scott, G., Hake, P., Kean, R., Virág, L., Szabó, C., Hooper, D.: Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis.
J. Neuroimmunol. 117 (1-2), 78-86, 2001.

Liaudet, L., Szabó, É., Timashpolsky, L., Virág, L., Cziráki, A., Szabó, C.: Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long term morphological and functional consequences.
Br. J. Pharmacol. 133 (8), 1424-1430, 2001.

Virág, L., Szabó, C.: BCL-2 protects peroxynitrite-treated thymocytes from poly(ADP-ribose) synthase (PARS)-independent apoptotic but not from PARS-mediated necrotic cell death.
Free Radic. Biol. Med. 29 (8), 704-713, 2000.

Haskó, G., Kuhel, D., Németh, Z., Mabley, J., Stachlewitz, R., Virág, L., Lohinai, Z., Southan, G., Salzman, A., Szabó, C.: Inosine inhibits inflammatory cytokine production by a posttranscriptional mechanism and protects against endotoxin-induced shock.
J. Immunol. 164 (2), 1013-1019, 2000.

Liaudet, L., Soriano, F., Szabó, É., Virág, L., Mabley, J., Salzman, A., Szabó, C.: Protection against hemorrhagic shock in mice genetically deficient in poly(ADP-ribose)polymerase.
Proc. Natl. Acad. Sci. USA. 97 (18), 10203-10208, 2000.

Virág, L.: The role of PARP in hte immune system.
In: Cell death: the role of PARP / Szabo C, CRC Press, Boca Raton, Florida, 131-166, 2000.

Whalen, M., Clark, R., Dixon, C., Robichaud, P., Marion, D., Vagni, V., Graham, S., Virág, L., Haskó, G., Stachlewitz, R., Szabó, C., Kochanek, P.: Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report.
Acta Neurochir. Suppl. 76 61-64, 2000.

Virág, L., Szabó, C.: Inhibition of poly(ADP-ribose) synthetase (PARS) and protection against peroxynitrite-induced cytotoxicity by zinc chelation.
Br. J. Pharmacol. 126 (3), 769-777, 1999.

Whalen, M., Clark, R., Dixon, C., Robichaud, P., Maion, D., Vagni, V., Graham, S., Virág, L., Haskó, G.: Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase.
J. Cereb. Blood Flow Metab. 19 (8), 835-842, 1999.

Ajuebor, M., Das, A., Virág, L., Szabó, C., Perretti, M.: Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation.
Biochem. Biophys. Res. Commun. 255 (2), 279-282, 1999.

Virág, L., Scott, G., Antal-Szalmás, P., O'Connor, M., Ohshima, H., Szabó, C.: Requirement of intracellular calcium mobilization for peroxynitrite-induced poly(ADP-ribose) synthetase activation and cytotoxicity.
Mol. Pharmacol. 56 (4), 824-833, 1999.

Ajuebor, M., Das, A., Virág, L., Flower, R., Szabó, C., Perretti, M.: Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: evidence for an inhibitory loop involving endogenous IL-10.
J. Immunol. 162 (3), 1685-1691, 1999.

Virág, L., Marmer, D., Szabó, C.: Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation.
Free Radic. Biol. Med. 25 (9), 1075-1082, 1998.

Szabó, C., Virág, L., Salzman, A.: FAS-induced apoptosis of murine peritoneal macrophages is mediated by nitric oxide.
In: The biology of nitroc oxide. Vol. 6.. Eds.: Moncada S., Toda N., Maeda H., Higgs E. A, Portland Press, London, 255, 1998.

Gilad, E., Wong, H., Zingarelli, B., Virág, L., O'Connor, M., Salzman, A., Szabó, C.: Melatonin inhibits expression of the inducible isoform of nitric oxide synthase in murine macrophages: role of inhibition of NFkappaB activation.
Faseb J. 12 (9), 685-693, 1998.

Virág, L., Haskó, G., Salzman, A., Szabó, C.: NADPH diaphorase histochemistry detects inducible nitric oxide synthetase activity in the thymus of naive and staphylococcal enterotoxin B-stimulated mice.
J. Histochem. Cytochem. 46 (7), 787-791, 1998.

Downing, J., Virág, L., Jones, I.: NADPH diaphorase-positive dendritic profiles in rat thymus are discrete from autofluorescent cells, immunoreactive for inducible nitric oxide synthase, and show strain-specific abundance differences.
Immunology. 95 (1), 148-155, 1998.

Downing, J., Virág, L., Perry, M.: Nitrergic mechanism of DC-mediated T-cell elimination.
Immunol. Today. 19 (4), 190-191, 1998.

Zingarelli, B., Virág, L., Szabó, A., Cuzzocrea, S., Salzman, A., Szabó, C.: Oxidation, tyrosine nitration and cytostasis induction in the absence of inducible nitric oxide synthase.
Int. J. Mol. Med. 1 (5), 787-795, 1998.

Virág, L., Scott, G., Cuzzocrea, S., Marmer, D., Salzman, A., Szabó, C.: Peroxynitrite-induced thymocyte apoptosis: the role of caspases and poly (ADP-ribose) synthetase (PARS) activation.
Immunology. 94 (3), 345-355, 1998.

Virág, L., Salzman, A., Szabó, C.: Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death.
J. Immunol. 161 (7), 3753-3759, 1998.

Szabó, C., Virág, L., Cuzzocrea, S., Scott, G., Hake, P., O'Connor, M., Zingarelli, B., Salzman, A., Kun, E.: Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase.
Proc. Natl. Acad. Sci. U. S. A. 95 (7), 3867-3872, 1998.

Ajuebor, M., Virág, L., Flower, R., Perretti, M., Szabó, C.: Role of inducible nitric oxide synthase in the regulation of neutrophil migration in zymosan-induced inflammation.
Immunology. 95 (4), 625-630, 1998.

Szabó, C., Virág, L., Zingarelli, B., Scott, G., Cuzzocrea, S., O'Connor, M., Salzman, A.: Role of poly(ADP-ribose) synthetase in the peroxynitrite- and nitric oxide-induced cytoxicity: studies in a PARS knockout fibroblast cell line.
In: The biology of nitric oxide. Vol. 6.. Eds.: Moncada S., Toda N., Maeda H., Higgs E. A, Portland Press, London, 279, 1998.

Szabó, C., Scott, G., Virág, L., Egnaczyk, G., Salzman, A., Shanley, T., Haskó, G.: Suppression of macrophage inflammatory protein (MIP)-1alpha production and collagen-induced arthritis by adenosine receptor agonists.
Br. J. Pharmacol. 125 (2), 379-387, 1998.

Haskó, G., Virág, L., Egnaczyk, G., Salzman, A., Szabó, C.: The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylococcal enterotoxin B.
Eur. J. Immunol. 28 (4), 1417-1425, 1998.

Kerékgyártó, C., Virág, L., Tankó, L., Chihara, G., Fachet, J.: Strain differences in the cytotoxic activity and TNF production of murine macrophages stimulated by lentinan.
Int. J. Immunopharmacol. 18 (6-7), 347-353, 1996.

Virág, L., Kerékgyártó, C., Fachet, J.: A simple, rapid and sensitive fluorimetric assay for the measurement of cell-mediated cytotoxicity.
J. Immunol. Methods. 185 (2), 199-208, 1995.

Imre, S., Pénzes, L., Virág, L., Noble, R., Fischer, H.: Possible auto-regulation in the rate of aging.
In: Modification of the rate of aging, Vienna aging series, volume 3. Eds.: Ruiz-Torres A., Hofecker G, Facultas Universitatsverlag, Wien, Austria, 87-88, 1992.

Virág, L., Imre, S.: Auto-oxidation test for the determination of lipid peroxidation capacity of liver tissue homogenates of young and old mice.
Z. Gerontol. Geriatr. 24 319-322, 1990.