Tudóstér: Lekli István publikációi

Herczeg, M., Demeter, F., Nagy, T., Rusznyák, Á., Hodek, J., Sipos, É., Lekli, I., Fenyvesi, F., Weber, J., Kéki, S., Borbás, A.: Block Synthesis and Step-Growth Polymerization of C-6-Sulfonatomethyl-Containing Sulfated Malto-Oligosaccharides and Their Biological Profiling.
Int. J. Mol. Sci. 25 (1), 1-29, 2024.

Demeter, F., Peleskei, Z., Kútvölgyi, K., Rusznyák, Á., Fenyvesi, F., Kajtár, R., Sipos, É., Lekli, I., Molnár, P., Szöllősi, A., Lisztes, E., Tóth, I., Borbás, A., Herczeg, M.: Synthesis and Biological Profiling of Seven Heparin and Heparan Sulphate Analogue Trisaccharides.
Biomolecules. 14 (9), 1-24, 2024.

Fésüs, A., Baluku, P., Sipos, É., Somodi, S., Berczi-Kun, E., Lekli, I., Bácskay, I., Benkő, R., Vaskó, A.: The effect of the antibiotic stewardship program (ASP) on community-acquired pneumonia (CAP): a before-after study.
Front. Pharm. 15 1-12, 2024.

Gyöngyösi, A., Csáki, N., Pető, Á., Szőke, K., Fenyvesi, F., Bácskay, I., Lekli, I.: BGP-15 Protects against Doxorubicin-Induced Cell Toxicity via Enhanced Mitochondrial Function.
Int. J. Mol. Sci. 24 (6), 1-13, 2023.

To Quoc, T., Bíró, K., Pető, Á., Kósa, D., Sinka, D., Lekli, I., Kiss-Szikszai, A., Budai, I., Béres, M., Vecsernyés, M., Fehér, P., Bácskay, I., Ujhelyi, Z.: Development and Evaluation of an FDM Printed Nasal Device for CPZ Solid Nanoparticles.
Molecules. 28 (11), 1-15, 2023.

Fésüs, A., Ábrahám, A., Sipos, É., Szőke, K., Bak, I., Kiss-Szikszai, A., Lekli, I.: Evaluation of the antioxidant effect of kd15 and kd36 newly synthetized molecules.
In: FAMÉ 2023 Mátraháza 7-9 June 2023 : Programme Oral and Poster Abstract / org. Hungarian Society For Experimental And Clinical Pharmacology, Hungarian Physiological Society, Hungarian Society For Microcirculation And Vascular Biology, HUPHAR, [S.l.], 223, 2023.

Fésüs, A., Matuz, M., Papfalvi, E., Hambalek, H., Ruzsa, R., Tánczos, B., Bácskay, I., Lekli, I., Illés, Á., Benkő, R.: Evaluation of the Diagnosis and Antibiotic Prescription Pattern in Patients Hospitalized with Urinary Tract Infections: single-Center Study from a University-Affiliated Hospital.
Antibiotics-Basel. 12 (12), 1-19, 2023.

Frei, G., Haimhoffer, Á., Csapó, E., Bodnár, K., Vasvári, G., Nemes, D., Lekli, I., Gyöngyösi, A., Bácskay, I., Fehér, P., Józsa, L.: In Vitro and In Vivo Efficacy of Topical Dosage Forms Containing Self-Nanoemulsifying Drug Delivery System Loaded with Curcumin.
Pharmaceutics. 15 (8), 1-8, 2023.

Szőke, K., Kajtár, R., Gyöngyösi, A., Czompa, A., Fésüs, A., Lőrincz, E., Petróczi, D., Herczegh, P., Bak, I., Borbás, A., Bereczki, I., Lekli, I.: Pharmacological Evaluation of Newly Synthesized Cannabidiol Derivates on H9c2 Cells.
Antioxidants. 12 (9), 1-15, 2023.

Szőke, K., Bódi, B., Hendrik, Z., Czompa, A., Gyöngyösi, A., Haines, D., Papp, Z., Tósaki, Á., Lekli, I.: Rapamycin treatment increases survival, autophagy biomarkers and expression of the anti-aging klotho protein in elderly mice.
Pharmacol. Res. & Perspec. 11 (3), 1-11, 2023.

Csépányi, E., Gyöngyösi, A., Lekli, I., Tósaki, Á., Bak, I.: Beta-Carotene Affects the Effects of Heme Oxygenase-1 in Isolated, Ischemic/Reperfused Rat Hearts: potential Role of the Iron.
Molecules. 27 (9), 1-12, 2022.

Józsa, L., Vasvári, G., Sinka, D., Nemes, D., Ujhelyi, Z., Vecsernyés, M., Váradi, J., Fenyvesi, F., Lekli, I., Gyöngyösi, A., Bácskay, I., Fehér, P.: Enhanced Antioxidant and Anti-Inflammatory Effects of Self-Nano and Microemulsifying Drug Delivery Systems Containing Curcumin.
Molecules. 27 (19), 1-22, 2022.

Gyöngyösi, A., Verner, V., Bereczki, I., Kiss-Szikszai, A., Zilinyi, R., Tósaki, Á., Bak, I., Borbás, A., Herczegh, P., Lekli, I.: Basic Pharmacological Characterization of EV-34, a New H2S-Releasing Ibuprofen Derivative.
Molecules. 26 (3), 1-12, 2021.

Mile, M., Balogh, L., Papp, G., Pucsok, J., Szabó, K., Barna, L., Csiki, Z., Lekli, I.: Effects of Functional Training on Sarcopenia in Elderly Women in the Presence or Absence of ACE Inhibitors.
Int. J. Environ. Res. Public Health. 18 (12), 1-11, 2021.

Pető, Á., Kósa, D., Haimhoffer, Á., Fehér, P., Ujhelyi, Z., Sinka, D., Fenyvesi, F., Váradi, J., Vecsernyés, M., Gyöngyösi, A., Lekli, I., Szentesi, P., Marton, A., Gombos, I., Dukic, B., Vígh, L., Bácskay, I.: Nicotinic Amidoxime Derivate BGP-15, Topical Dosage Formulation and Anti-Inflammatory Effect.
Pharmaceutics. 13 (12), 2037, 2021.

Haimhoffer, Á., Fenyvesi, F., Lekli, I., Béres, M., Bak, I., Czagány, M., Vasvári, G., Bácskay, I., Tóth, J., Budai, I.: Preparation of Acyclovir-Containing Solid Foam by Ultrasonic Batch Technology.
Pharmaceutics. 13 (10), 1-15, 2021.

Lódi, M., Bánhegyi, V., Bódi, B., Gyöngyösi, A., Kovács, Á., Árokszállási, A., Hamdani, N., Fagyas, M., Édes, I., Csanádi, Z., Czuriga, I., Kisvárday, Z., Lekli, I., Bai, P., Tóth, A., Papp, Z., Czuriga, D.: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy.
J. Transl. Med. 18 (1), 470, 2020.

Lódi, M., Priksz, D., Fülöp, G., Bódi, B., Gyöngyösi, A., Nagy, L., Kovács, Á., Kertész, A., Kocsis, J., Édes, I., Csanádi, Z., Czuriga, I., Kisvárday, Z., Juhász, B., Lekli, I., Bai, P., Tóth, A., Papp, Z., Czuriga, D.: Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy.
J. Transl. Med. 17 229, 2019.

Mile, M., Csiki, Z., Bihari, K., Papp-Bata, Á., Lekli, I.: A funkcionális edzés hatása a sarcopéniára 65 év felettiek körében.
In: A Magyar Allergológiai és Klinikai Immunológiai Társaság 47. Kongresszusa : Absztraktok. Szerk.: Novák Zoltán, Magyar Allergológiai és Klinikai Immunológiai Társaság, Debrecen, 41, 2019.

Szőke, K., Czompa, A., Lekli, I., Szabados-Fürjesi, P., Herczeg, M., Csávás, M., Borbás, A., Herczegh, P., Tósaki, Á.: A new, vasoactive hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety.
Eur. J. Pharm. Sci. 131 159-166, 2019.

Szőke, K., Czompa, A., Lekli, I., Szabados-Fürjesi, P., Herczeg, M., Csávás, M., Borbás, A., Herczegh, P., Tósaki, Á.: Dataset on structure, stability and myocardial effects of a new hybrid aspirin containing nitrogen monoxide-releasing molsidomine moiety.
Data brief. 25 1-10, 2019.

Czeglédi, A., Tósaki, Á., Gyöngyösi, A., Zilinyi, R., Tósaki, Á., Lekli, I.: Electrically-Induced Ventricular Fibrillation Alters Cardiovascular Function and Expression of Apoptotic and Autophagic Proteins in Rat Hearts.
Int. J. Mol. Sci. 20 (7), 1-12, 2019.

Gyöngyösi, A., Szőke, K., Fenyvesi, F., Fejes, Z., Bekéné Debreceni, I., Nagy, B., Tósaki, Á., Lekli, I.: Inhibited autophagy may contribute to heme toxicity in cardiomyoblast cells.
Biochem. Biophys. Res. Commun. 511 (4), 732-738, 2019.

Gyöngyösi, A., Zilinyi, R., Czeglédi, A., Tósaki, Á., Tósaki, Á., Lekli, I.: The role of autophagy and death pathways in dose-dependent isoproterenol-induced cardiotoxicity.
Curr. Pharm. Design. 25 (19), 2192-2198, 2019.

Czompa, A., Szőke, K., Prokisch, J., Gyöngyösi, A., Bak, I., Balla, G., Tósaki, Á., Lekli, I.: Aged (Black) versus Raw Garlic against Ischemia/Reperfusion-Induced Cardiac Complications.
Int. J. Mol. Sci. 19 (4), 1-13, 2018.

Barta, T., Tósaki, Á., Haines, D., Balla, G., Lekli, I., Tósaki, Á.: Endothelin-1-induced hypertrophic alterations and heme oxygenase-1 expression in cardiomyoblasts are counteracted by beta estradiol: in vitro and in vivo studies.
Naunyn-Schmiedebergs Arch. Pharmacol. 391 (4), 371-383, 2018.

Zilinyi, R., Czompa, A., Czeglédi, A., Gajtkó, A., Pituk, D., Lekli, I., Tósaki, Á.: The Cardioprotective Effect of Metformin in Doxorubicin-Induced Cardiotoxicity: the Role of Autophagy.
Molecules. 23 (5), 1-12, 2018.

Csépányi, E., Czompa, A., Szabados-Fürjesi, P., Lekli, I., Balla, J., Balla, G., Tósaki, Á., Bak, I.: The Effects of Long-Term, Low- and High-Dose Beta-Carotene Treatment in Zucker Diabetic Fatty Rats: the Role of HO-1.
Int. J. Mol. Sci. 19 (4), 1-13, 2018.

Gyöngyösi, A., Terraneo, L., Bianciardi, P., Tósaki, Á., Lekli, I., Samaja, M.: The Impact of Moderate Chronic Hypoxia and Hyperoxia on the Level of Apoptotic and Autophagic Proteins in Myocardial Tissue.
Oxidative Medicine and Cellular Longevity. 2018 1-12, 2018.

Csépányi, E., Szabados-Fürjesi, P., Kiss-Szikszai, A., Frensemeier, L., Karst, U., Lekli, I., Haines, D., Tósaki, Á., Bak, I.: Antioxidant Properties and Oxidative Transformation of Different Chromone Derivatives.
Molecules. 22 (4), 1-12, 2017.

Lekli, I., Haines, D., Balla, G., Tósaki, Á.: Autophagy: an adaptive physiologic countermeasure to cellular senescence and ischemia/reperfusion-associated cardiac arrhythmias.
J. Cell. Mol. Med. 21 (6), 1058-1072, 2017.

Czompa, A., Gyöngyösi, A., Szőke, K., Bak, I., Csépányi, E., Haines, D., Tósaki, Á., Lekli, I.: Effects of Momordica charantia (Bitter Melon) on Ischemic Diabetic Myocardium.
Molecules. 22 (3), 488, 2017.

Klionsky, D., Fésüs, L., Lekli, I.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12 (1), 1-222, 2016.

Csépányi, E., Czompa, A., Haines, D., Lekli, I., Bakondi, E., Balla, G., Tósaki, Á., Bak, I.: Cardiovascular effects of low versus high-dose beta-carotene in a rat model.
Pharmacol. Res. 100 148-156, 2015.

Bak, I., Lekli, I.: Gyógyszerészi műszeres és bioanalitika gyakorlatok.
Debreceni Egyetem, Debrecen, 125 p., 2015.

Csiki, Z., Papp-Bata, Á., Czompa, A., Nagy, A., Bak, I., Lekli, I., Jávor, A., Haines, D., Balla, G., Tósaki, Á.: Orally delivered sour cherry seed extract (SCSE) affects cardiovascular and hematological parameters in humans.
Phytother. Res. 29 (3), 444-449, 2015.

Bak, I., Lekli, I.: Selected chapters from thepharmaceutical and bioanalysis.
Debreceni Egyetem, Debrecen, 122 p., 2015.

Czompa, A., Gyöngyösi, A., Czeglédi, A., Csépányi, E., Bak, I., Haines, D., Tósaki, Á., Lekli, I.: Cardioprotection afforded by sour cherry seed kernel: the role of heme oxygenase-1.
J. Cardiovasc. Pharmacol. 64 (5), 412-419, 2014.

Czompa, A., Nagy, A., Bak, I., Hendrik, Z., Lekli, I., Csiki, Z., Tósaki, Á.: Consumer investigation and toxicological analysis of sour cherry seed kernel extract.
Acta Physiol. 211 (Suppl), 84, 2014.

Meyer, G., Czompa, A., Reboul, C., Csépányi, E., Czeglédi, A., Bak, I., Balla, G., Balla, J., Tósaki, Á., Lekli, I.: The Cellular Autophagy Markers Beclin-1 and LC3B-II are Increased during Reperfusion in Fibrillated Mouse Hearts.
Curr. Pharm. Des. 19 (39), 6912-6918, 2013.

Das, M., Das, S., Lekli, I., Das, D.: Caveolin induces cardioprotection through epigenetic regulation.
J. Cell. Mol. Med. 16 (4), 888-895, 2012.

Oros, M., Zavaczki, E., Vadász, C., Jeney, V., Tósaki, Á., Lekli, I., Balla, G., Nagy, L., Balla, J.: Ethanol increases phosphate-mediated mineralization and osteoblastic transformation of vascular smooth muscle cells.
J. Cell. Mol. Med. 16 (9), 2219-2226, 2012.

Haines, D., Lekli, I., Teissier, P., Bak, I., Tósaki, Á.: Role of haeme oxygenase-1 in resolution of oxidative stress-related pathologies: focus on cardiovascular, lung, neurological and kidney disorders.
Acta Physiol. 204 (4), 487-501, 2012.

Das, S., Mukherjee, S., Lekli, I., Gurusamy, N., Bardhan, J., Raychaudhuri, U., Chakravarty, R., Banerji, S., Knowlton, A., Das, D.: Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics.
Mol. Cell. Biochem. 360 (1-2), 35-45, 2012.

Galajda, Z., Balla, J., Szentmiklósi, J., Bíró, T., Czifra, G., Dobrosi, N., Cseppentő, Á., Patonay, L., Röszer, T., Balla, G., Popescu, L., Lekli, I., Tósaki, Á.: Histamine and H1-Histamine receptors faster venous circulation.
J. Cell. Mol. Med. 15 (12), 2614-2623, 2011.

Juhász, B., Varga, B., Czompa, A., Bak, I., Lekli, I., Gesztelyi, R., Zsuga, J., Kemény-Beke, Á., Antal, M., Szendrei, L., Tósaki, Á.: Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium.
J. Cell. Mol. Med. 15 (9), 1973-1982, 2011.

Haines, D., Varga, B., Bak, I., Juhász, B., Mahmoud, F., Kalantari, H., Gesztelyi, R., Lekli, I., Czompa, A., Tósaki, Á.: Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in Suppression of respiratory inflammation: a comparison with ibuprofen.
Phytother. Res. 25 (1), 128-136, 2011.

Gurusamy, N., Lekli, I., Mukherjee, S., Ray, D., Ahsan, M., Gherghiceanu, M., Popescu, L., Das, D.: Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway.
Cardiovasc. Res. 86 (1), 103-112, 2010.

Mukherjee, S., Lekli, I., Ray, D., Gangopadhyay, H., Raychaudhuri, U., Das, D.: Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury.
Br. J. Nutr. 103 (06), 815-823, 2010.

Lekli, I., Ray, D., Mukherjee, S., Gurusamy, N., Ahsan, M., Juhász, B., Bak, I., Tósaki, Á., Gherghiceanu, M., Popescu, L., Das, D.: Co-ordinated autophagy with resveratrol and gamma-tocotrienol confers synergetic cardioprotection.
J. Cell. Mol. Med. 14 (10), 2506-2518, 2010.

Gurusamy, N., Lekli, I., Ahsan, M., Ray, D., Mukherjee, S., Mascareno, E., Siddiqui, M., Das, D.: Downregulation of cardiac lineage protein-1 confers cardioprotection through the upregulation of redox effectors.
FEBS Lett. 584 (1), 187-193, 2010.

Mukherjee, S., Ray, D., Lekli, I., Bak, I., Tósaki, Á., Das, D.: Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action.
Can. J. Physiol. Pharmacol. 88 (11), 1017-1025, 2010.

Lekli, I., Mukherjee, S., Ray, D., Gurusamy, N., Kim, Y., Tósaki, Á., Engelman, R., Ho, Y., Das, D.: Functional recovery of diabetic mouse hearts by glutaredoxin-1 gene therapy: role of Akt-FoxO-signaling network.
Gene Ther. 17 (4), 478-485, 2010.

Bak, I., Lekli, I., Juhász, B., Varga, E., Varga, B., Gesztelyi, R., Szendrei, L., Tósaki, Á.: Isolation and Analysis of Bioactive Constituents of Sour Cherry (Prunus cerasus) Seed Kernel: an Emerging Functional Food.
J. Med. Food. 13 (4), 905-910, 2010.

Lekli, I., Ray, D., Das, D.: Longevity nutrients resveratrol, wines and grapes.
Genes Nutr. 5 (1), 55-60, 2010.

Vasanthi, H., Mukherjee, S., Ray, D., Pandian Jayachandran, K., Lekli, I., Das, D.: Protective role of air potato (Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury.
Food Funct. 1 (3), 278-283, 2010.

Bak, I., Czompa, A., Juhász, B., Lekli, I., Tósaki, Á.: Reduction of reperfusion-induced ventricular fibrillation and infarct size via heme oxygenase-1 overexpression in isolated mouse hearts.
J. Cell. Mol. Med. 14 (9), 2268-2272, 2010.

Gurusamy, N., Ray, D., Lekli, I., Das, D.: Red wine antioxidant resveratrol-modified cardiac stem cells regenerate infarcted myocardium.
J. Cell. Mol. Med. 14 (9), 2235-2239, 2010.

Lekli, I., Tósaki, Á.: Új irányvonalak a betegségek kezelésében a XXI-ik században: redox fehérjék lehetséges génterápiás alkalmazása.
Motesz Mag. 18 (4), 17-22, 2010.

Gurusamy, N., Lekli, I., Gherghiceanu, M., Popescu, L., Das, D.: BAG-1 induces autophagy for cardiac cell survival.
Autophagy. 5 (1), 120-122, 2009.

Gurusamy, N., Lekli, I., Gorbunov, N., Gherghiceanu, M., Popescu, L., Das, D.: Cardioprotection by adaptation to ischaemia augments autophagy in association with BAG-1 protein.
J. Cell. Mol. Med. 13 (2), 373-387, 2009.

Gurusamy, N., Mukherjee, S., Lekli, I., Bearzi, C., Bardelli, S., Das, D.: Inhibition of Ref-1 stimulates the production of reactive oxygen species and induces differentiation in adult cardiac stem cells.
Antioxid. Redox Signal. 11 (3), 589-599, 2009.

Vasanthi, H., Mukherjee, S., Lekli, I., Ray, D., Veeraraghavan, G., Das, D.: Potential role of borreria hispida in ameliorating cardiovascular risk factors.
J. Cardiovasc. Pharmacol. 53 (6), 499-506, 2009.

Ahsan, M., Lekli, I., Ray, D., Yodoi, J., Das, D.: Redox Regulation of Cell Survival by the Thioredoxin Superfamily: an Implication of Redox Gene Therapy in the Heart.
Antioxid. Redox Signal. 11 (11), 2741-2758, 2009.

Lekli, I., Gurusamy, N., Ray, D., Tósaki, Á., Das, D.: Redox regulation of stem cell mobilization.
Can. J. Physiol. Pharmacol. 87 (12), 989-995, 2009.

Mukherjee, S., Lekli, I., Das, M., Azzi, A., Das, D.: Cardioprotection with α-tocopheryl phosphate: amelioration of myocardial ischemia reperfusion injury is linked with its ability to generate a survival signal through Akt activation.
Biochim. Biophys. Acta. Mol. Basis Dis. 1782 (9), 498-503, 2008.

Lekli, I., Das, S., Das, S., Mukherjee, S., Bak, I., Juhász, B., Baghci, D., Trimurtulu, G., Krishnaraju, A., Sengupta, K., Tósaki, Á., Das, D.: Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10.
J. Agric. Food Chem. 56 (13), 5331-5337, 2008.

Das, M., Gherghiceanu, M., Lekli, I., Mukherjee, S., Popescu, L., Das, D.: Essential Role of Lipid Raft in Ischemic Preconditioning.
Cell. Physiol. Biochem. 21 (4), 325-334, 2008.

Lekli, I., Szabó, G., Juhász, B., Das, S., Das, M., Varga, E., Szendrei, L., Gesztelyi, R., Váradi, J., Bak, I., Das, D., Tósaki, Á.: Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin.
Am. J. Physiol. Heart Circ. Physiol. 294 H859-H866, 2008.

Juhász, B., Dér, P., Szodoray, P., Gesztelyi, R., Lekli, I., Bak, I., Antal, M., Maulik, N., Tósaki, Á., Vecsernyés, M.: Adrenocorticotrope hormone fragment (4-l0) attenuates the ischemia/reperfusion-induced cardiac injury in isolated rat hearts.
Antioxid. Redox Signal. 9 (11), 1851-1861, 2007.

Váradi, J., Lekli, I., Juhász, B., Bácskay, I., Szabó, G., Gesztelyi, R., Szendrei, L., Varga, E., Bak, I., Foresti, R., Motterlini, R., Tósaki, Á.: Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery.
Life Sci. 80 (17), 1619-1626, 2007.

Karsai, D., Gesztelyi, R., Zsuga, J., Jakab, A., Szendrei, L., Juhász, B., Bak, I., Szabó, G., Lekli, I., Vecsernyés, M., Varga, E., Szentmiklósi, J., Tósaki, Á.: Influence of hyperthyroidism on the effect of adenosine transport blockade assessed by a novel method in guinea pig atria.
Cell. Biochem. Biophys. 47 (1), 45-52, 2007.

Bak, I., Lekli, I., Juhász, B., Nagy, N., Varga, E., Váradi, J., Gesztelyi, R., Szabó, G., Szendrei, L., Bácskay, I., Vecsernyés, M., Antal, M., Fésüs, L., Boucher, F., de Leiris, J., Tósaki, Á.: Cardioprotective mechanisms of Prunus cerasus (sour cherry) seed extract against ischemia-reperfusion-induced damage in isolated rat hearts.
Am. J. Physiol.-Heart Circul. Physiol. 291 (3), H1329-H1336, 2006.