Tudóstér: Varga Zoltán publikációi

Pethő, Z., Pajtás, D., Piga, M., Magyar, Z., Zákány, F., Kovács, T., Zidar, N., Panyi, G., Varga, Z., Papp, F.: A synthetic flavonoid derivate in the plasma membrane transforms the voltage-clamp fluorometry signal of CiHv1.
FEBS J. [Epub ahead of print]2024.

Szántó, G., Fehér, Á., Korpos, É., Gyöngyösi, A., Kállai, J., Mészáros, B., Óvári, K., Lányi, Á., Panyi, G., Varga, Z.: 5-Chloro-2-Guanidinobenzimidazole (ClGBI) Is a Non-Selective Inhibitor of the Human HV1 Channel.
Pharmaceuticals (Basel). 16 (5), 1-15, 2023.

Kovács, Z., Óvári, J., Dienes, C., Magyar, J., Bányász, T., Nánási, P., Horváth, B., Fehér, Á., Varga, Z., Szentandrássy, N.: ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of IKr.
Pharmaceuticals (Basel). 16 (4), 488, 2023.

Zákány, F., Mándity, I., Varga, Z., Panyi, G., Nagy, P., Kovács, T.: Effect of the Lipid Landscape on the Efficacy of Cell-Penetrating Peptides.
Cells. 12 (13), 1-29, 2023.

Nemes, B., László, S., Zsidó, Z., Hetényi, C., Fehér, Á., Papp, F., Varga, Z., Szőke, É., Sándor, Z., Pintér, E.: Elucidation of the binding mode of organic polysulfides on the human TRPA1 receptor.
Front. Physiol. 14 1-16, 2023.

Szántó, G., Papp, F., Zákány, F., Varga, Z., Deutsch, C., Panyi, G.: Molecular rearrangements in S6 during slow inactivation in Shaker-IR potassium channels.
J. Gen. Physiol. 155 (7), 1-14, 2023.

Kovács, T., Kurtán, K., Varga, Z., Nagy, P., Panyi, G., Zákány, F.: Veklury (remdesivir) formulations inhibit initial membrane-coupled events of SARS-CoV-2 infection due to their sulfobutylether-β-cyclodextrin content.
Br. J. Pharmacol. 180 (16), 2064-2084, 2023.

Kovács, T., Nagy, P., Panyi, G., Szente, L., Varga, Z., Zákány, F.: Cyclodextrins: Only Pharmaceutical Excipients or Full-Fledged Drug Candidates?.
Pharmaceutics. 14 1-38, 2022.

Zákány, F., Kovács, T., Szente, L., Varga, Z.: Cyclodextrins as promising therapeutics against cholesterol overload.
In: Cholesterol. Ed.: Anna N. Bukiya, Alex M. Dopico, Academic Press Inc Elsevier Science, San Diego, 927-967, 2022. ISBN: 9780323858571

Fehér, Á., Pócsi, M., Papp, F., Szántó, G., Csóti, Á., Fejes, Z., Nagy, B., Nemes, B., Varga, Z.: Functional Voltage-Gated Sodium Channels Are Present in the Human B Cell Membrane.
Cells. 11 (7), 1-15, 2022.

Bátai, I., Dombi, Á., Borbély, É., Fehér, Á., Papp, F., Varga, Z., Mócsai, A., Helyes, Z., Pintér, E., Pozsgai, G.: Investigation of the Role of the TRPA1 Ion Channel in Conveying the Effect of Dimethyl Trisulfide on Vascular and Histological Changes in Serum-Transfer Arthritis.
Pharmaceuticals (Basel). 15 (6), 1-15, 2022.

Fehér, Á., Pethő, Z., Szántó, G., Klekner, Á., Tajti, G., Batta, G., Hortobágyi, T., Varga, Z., Schwab, A., Panyi, G.: Mapping the functional expression of auxiliary subunits of KCa1.1 in glioblastoma.
Sci. Rep. 12 (1), 1-14, 2022.

Papp, F., Toombes, G., Pethő, Z., Bagosi, A., Fehér, Á., Almássy, J., Borrego, J., Kuki, Á., Kéki, S., Panyi, G., Varga, Z.: Multiple mechanisms contribute to fluorometry signals from the voltage-gated proton channel.
Commun Biol. 5 (1), 1131, 2022.

Borrego, J., Naseem, M., Sehgal, A., Panda, L., Shakeel, K., Gáspár, A., Nagy, C., Varga, Z., Panyi, G.: Recombinant Expression in Pichia pastoris System of Three Potent Kv1.3 Channel Blockers: Vm24, Anuroctoxin, and Ts6.
J. Fungi. 8 (11), 1-15, 2022.

Csóti, Á., del Carmen Nájera, M., Bogár, F., Tajti, G., Szántó, G., Varga, Z., Gurrola-Briones, G., Tóth, G., Possani, L., Panyi, G.: sVmKTx, a transcriptome analysis-based synthetic peptide analogue of Vm24, inhibits Kv1.3 channels of human T cells with improved selectivity.
Biochem. Pharmacol. 199 1-14, 2022.

Zákány, F., Szabó, M., Batta, G., Kárpáti, L., Mándity, I., Fülöp, P., Varga, Z., Panyi, G., Nagy, P., Kovács, T.: An [omega]-3, but Not an [omega]-6 Polyunsaturated Fatty Acid Decreases Membrane Dipole Potential and Stimulates Endo-Lysosomal Escape of Penetratin.
Front. Cell. Dev. Biol. 9 1-17, 2021.

Kovács, T., Sohajda, T., Szente, L., Nagy, P., Panyi, G., Varga, Z., Zákány, F.: Cyclodextrins exert a ligand-like current inhibitory effect on the KV1.3 ion channel independent of membrane cholesterol extraction.
Front. Mol. Biosci. 8 1-11, 2021.

Borrego, J., Fehér, Á., Jost, N., Panyi, G., Varga, Z., Papp, F.: Peptide Inhibitors of Kv1.5: an Option for the Treatment of Atrial Fibrillation.
Pharmaceuticals (Basel). 14 (12), 1-21, 2021.

Szántó, G., Gaál, S., Karbat, I., Varga, Z., Reuveny, E., Panyi, G.: Shaker-IR K+ channel gating in heavy water: role of structural water molecules in inactivation.
J. Gen. Physiol. 153 (6), 1-27, 2021.

Varga, Z., Tajti, G., Panyi, G.: The Kv1.3 K+ channel in the immune system and its "precision pharmacology" using peptide toxins.
BIOLOGIA FUTURA. 72 (1), 75-83, 2021.

Zákány, F., Kovács, T., Panyi, G., Varga, Z.: Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels.
Biochim. Biophys. Acta. Mol. Cell Biol. Lipids. 1865 (8), 1-27, 2020.

Papp, F., Hajdu, P., Tajti, G., Tóth, Á., Nagy, É., Fazekas, Z., Kovács, S., Vámosi, G., Varga, Z., Panyi, G.: Periodic Membrane Potential and Ca2+ Oscillations in T Cells Forming an Immune Synapse.
Int. J. Mol. Sci. 21 (5), 1-19, 2020.

Szántó, G., Zákány, F., Papp, F., Varga, Z., Deutsch, C., Panyi, G.: The activation gate controls steady-state inactivation and recovery from inactivation in Shaker.
J. Gen. Physiol. 152 (8), 1-12, 2020.

Zákány, F., Pap, P., Papp, F., Kovács, T., Nagy, P., Péter, M., Szente, L., Panyi, G., Varga, Z.: Determining the target of membrane sterols on voltage-gated potassium channels.
Biochim. Biophys. Acta. Mol. Cell Biol. Lipids. 1864 (3), 312-325, 2019.

Matta, C., Juhász, T., Fodor, J., Hajdú, T., Katona, É., Somogyi, C., Takács, R., Vágó, J., Oláh, T., Bartók, Á., Varga, Z., Panyi, G., Csernoch, L., Zákány, R.: N-methyl-D-aspartate (NMDA) receptor expression and function is required for early chondrogenesis.
Cell Commun Signal. 17 (1), 166, 2019.

Zákány, F., Papp, F., Panyi, G., Varga, Z.: Determining the Target of Membrane Sterols on the Gating of Voltage-Gated Potassium Channels using Voltage-Clamp Fluorometry.
Biophys. J. 114 (3), 477a, 2018.

Zhu, W., Voelker, T., Varga, Z., Schubert, A., Nerbonne, J., Silva, J.: Mechanisms of noncovalent β subunit regulation of NaV channel gating.
J. Gen. Physiol. 149 (8), 813-831, 2017.

Pajtás, D., Kónya, K., Kiss-Szikszai, A., Džubák, P., Pethő, Z., Varga, Z., Panyi, G., Patonay, T.: Optimization of the Synthesis of Flavone-Amino Acid and Flavone-Dipeptide Hybrids via Buchwald-Hartwig Reaction.
J. Org. Chem. 82 (9), 4578-4587, 2017.

Tomczak, A., Papp, F., Zákány, F., Pap, P., Pardo, L., Panyi, G., Varga, Z.: Probing the Gating of Kv10. 1 Channels by MTS Reagents.
Biophys. J. 112 (3), 248a, 2017.

Hsu, E., Zhu, W., Schubert, A., Voelker, T., Varga, Z., Silva, J.: Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains.
J. Gen. Physiol. 149 (3), 389-403, 2017.

Balajthy, A., Hajdu, P., Panyi, G., Varga, Z.: Sterol Regulation of Voltage-Gated K+ Channels.
Current Topics In Membranes. 80 255-292, 2017.

Balajthy, A., Pethő, Z., Somodi, S., Varga, Z., Péter, M., Vígh, L., P. Szabó, G., Paragh, G., Panyi, G., Hajdu, P.: 7-Dehydrocholesterol Modifies the Operation of Kv1.3 Channels in T Cells Isolated from Smith-Lemli-Opitz Syndrome Patients.
Biophys. J. 110 (3), 278a-279a, 2016.

Balajthy, A., Somodi, S., Pethő, Z., Péter, M., Varga, Z., P. Szabó, G., Paragh, G., Vígh, L., Panyi, G., Hajdu, P.: 7DHC-induced changes of Kv1.3 operation contributes to modified T cell function in Smith-Lemli-Opitz syndrome.
Pflügers Arch. 468 (8), 1403-1418, 2016.

Zhu, W., Varga, Z., Silva, J.: Molecular motions that shape the cardiac action potential: insights from voltage clamp fluorometry.
Prog. Biophys. Mol. Biol. 120 (1-3), 3-17, 2016.

Fehér, K., Timári, I., Rákosi, K., Szolomájer, J., Illyés, T., Bartók, Á., Varga, Z., Panyi, G., Tóth, G., Kövér, K.: Probing pattern and dynamics of disulfide bridges using synthesis and NMR of an ion channel blocker peptide toxin with multiple diselenide bonds.
Chem. Sci. 7 2666-2673, 2016.

Szántó, G., Gaál, S., Varga, Z., Panyi, G.: Shaker-IR K Channel Gating in Heavy Water: Role of Structural Water Molecules in Inactivation.
Biophys. J. 110 (3), 343a-344a, 2016.

Pethő, Z., Balajthy, A., Bartók, Á., Bene, K., Somodi, S., Szilágyi, O., Rajnavölgyi, É., Panyi, G., Varga, Z.: The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation.
Immunol. Lett. 171 60-69, 2016.

Pap, P., Pethő, Z., Panyi, G., Varga, Z.: The Effect of Membrane Cholesterol Content on the Gating Mechanism of Voltage Gated Potassium Channels.
Biophys. J. 110 (3), 104a, 2016.

Bartók, Á., Fehér, K., Bodor, A., Rákosi, K., Tóth, G., Kövér, K., Panyi, G., Varga, Z.: An engineered scorpion toxin analogue with improved Kv1.3 selectivity displays reduced conformational flexibility.
Sci. Rep. 5 (18397), 1-13, 2015.

Varga, Z., Zhu, W., Schubert, A., Pardieck, J., Krumholz, A., Hsu, E., Zaydman, M., Cui, J., Silva, J.: Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations.
Circ.-Arrhythmia Electrophysiol. 8 (5), 1228-1239, 2015.

Bartók, Á., Panyi, G., Varga, Z.: Potassium Channel-Blocking Peptide Toxins from Scorpion Venom.
In: Toxinology : Scorpion Venoms. Eds.: Gopalakrishnakone, P., Possani, L.D., F. Schwartz, E., Rodríguez de la Vega, Springer Netherlands, Dordrecht, 493-527, 2015. ISBN: 9789400766471

Papp, F., Szántó, G., Varga, Z., Zákány, F., Panyi, G.: Activation Gate Opening Precedes Slow Inactivation in Shaker K+ Channels.
Biophys. J. 102 (3), 531a, 2014.

Bartók, Á., Tóth, Á., Somodi, S., Szántó, G., Hajdu, P., Panyi, G., Varga, Z.: Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.
Toxicon. 87 6-16, 2014.

Rudokas, M., Varga, Z., Schubert, A., Asaro, A., Silva, J.: The Xenopus Oocyte Cut-open Vaseline Gap Voltage-clamp Technique With Fluorometry.
JoVE. 2014 (85), 2014.

Gurrola-Briones, G., Hernandez-Lopez, R., Rodriguez de, l., Varga, Z., Batista, C., Salas-Castillo, S., Panyi, G., del Rio, -., Possani, L.: Structure, function, and chemical synthesis of Vaejovis mexicanus peptide 24: a novel potent blocker of Kv1.3 potassium channels of human T lymphocytes.
Biochemistry. 51 (19), 4049-4061, 2012.

Varga, Z., Gurrola-Briones, G., Papp, F., Rodríguez, R., Pedraza-Alva, G., Tajhya, R., Gáspár, R., Cardenas, L., Rosenstein, Y., Beeton, C., Possani, L., Panyi, G.: Vm24, a natural immunosuppressive peptide, potently and selectively blocks Kv1.3 potassium channels of human T cells.
Mol. Pharmacol. 82 (3), 372-382, 2012.

Varga, Z., Juhász, T., Matta, C., Fodor, J., Katona, É., Bartók, Á., Oláh, T., Sebe, A., Csernoch, L., Panyi, G., Zákány, R.: Switch of voltage-gated k channel expression in the plasma membrane of chondrogenic cells affects cytosolic ca-oscillations and cartilage formation.
PLoS One. 6 (11), e27957, 2011.

Varga, Z., Hajdu, P., Panyi, G.: Ion channels in T lymphocytes: an update on facts, mechanisms and therapeutic targeting in autoimmune diseases.
Immunol. Lett. 130 (1-2), 19-25, 2010.

Varga, Z., Csépány, T., Papp, F., Fábián, Á., Gogolák, P., Tóth, Á., Panyi, G.: Potassium channel expression in human CD4(+) regulatory and naive T cells from healthy subjects and multiple sclerosis patients.
Immunol. Lett. 124 (2), 95-101, 2009.

Papp, F., Batista, C., Varga, Z., Herceg, M., Roman-Gonzalez, S., Gáspár, R., Possani, L., Panyi, G.: Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus.
Toxicon. 54 (4), 379-389, 2009.

Corzo, G., Papp, F., Varga, Z., Barraza, O., Espino-Solis, P., Rodriguez de, l., Gáspár, R., Panyi, G., Possani, L.: A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venomof the scorpion Centruroides suffusus suffusus.
Biochem. Pharmacol. 76 (9), 1142-1154, 2008.

Papp, F., Hajdu, P., Varga, Z., Zsíros, E., Ludányi, K., Gáspár, R., Rajnavölgyi, É., Panyi, G.: CRAC channels in developing human dendritic cells.
Biophys. J. 94 (Suppl), 2008.

Somodi, S., Hajdu, P., Gáspár, R., Panyi, G., Varga, Z.: Effects of changes in extracellular pH and potassium concentration on Kv1.3 inactivation.
Eur. Biophys. J. 37 (7), 1145-1156, 2008.

Varga, Z., Hajdu, P., Panyi, G., Gáspár, R., Krasznai, Z.: Involvement of membrane channels in autoimmune disorders.
Curr. Pharm. Des. 13 (24), 2456-2468, 2007.

Detre, C., Kiss, E., Varga, Z., Ludányi, K., Pászty, K., Enyedi, Á., Kövesdi, D., Panyi, G., Rajnavölgyi, É., Matkó, J.: Death or survival: membrane ceramide controls the fate and activation of antigen-specific T-cells depending on signal strength and duration.
Cell. Signal. 18 (3), 294-306, 2006.

Panyi, G., Possani, L., Rodriguez de, l., Gáspár, R., Varga, Z.: K+ channel blockers: novel tools to inhibit T cell activation leading to specific immunosuppression.
Curr. Pharm. Des. 12 (18), 2199-2220, 2006.

Vámosi, G., Dóczy-Bodnár, A., Damjanovich, S., Nagy, P., Varga, Z., Damjanovich, L.: The role of supramolecular protein complexes and membrane potential in transmembrane signaling processes of lymphocytes.
Immunol. Lett. 104 (1-2), 53-58, 2006.

Bagdány, M., Batista, C., Valdez-Cruz, N., Somodi, S., Rodriguez de, l., Licea, A., Varga, Z., Gáspár, R., Possani, L., Panyi, G.: Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.
Mol. Pharmacol. 67 (4), 1034-1044, 2005.

Detre, C., Kiss, E., Varga, Z., Ludányi, K., Pászty, K., Enyedi, Á., Panyi, G., Rajnavölgyi, É., Matkó, J.: Dual face of ceramide: non-apoptotic Cer-stimuli modulate antigen-specific T-cell activation through blocking plasma membrane ion channels.
FEBS J. 272 (Suppl1), 193, 2005.

Olamendi-Portugal, T., Somodi, S., Fernandez, J., Zamudio, F., Becerril, B., Varga, Z., Panyi, G., Gáspár, R., Possani, L.: Novel alpha-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells.
Toxicon. 46 (4), 418-429, 2005.

Varga, Z., Gáspár, R.: Signal transduction by ion channels in Lymphocytes.
In: Biophysical Aspects of Transmembrane Signaling. Szerk.: Damjanovich S, Springer-Verlag, Berlin Heidelberg, 293-315, 2005.

Somodi, S., Varga, Z., Levy, D., Gáspár, R., Panyi, G.: The role of His399 in the pH-dependent modulation of Kv1.3 inactivation.
Biophys. J. 88 (1), 278A, 2005.

Panyi, G., Varga, Z., Gáspár, R.: Ion channels and lymphocyte activation.
Immunol. Lett. 92 (1-2), 55-66, 2004.

Panyi, G., Vámosi, G., Bacsó, Z., Dóczy-Bodnár, A., Bagdány, M., Varga, Z., Gáspár, R., Mátyus, L., Damjanovich, S.: Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.
Proc. Natl. Acad. Sci. U.S.A. 101 (5), 1285-1290, 2004.

Vámosi, G., Bacsó, Z., Dóczy-Bodnár, A., Bagdány, M., Varga, Z., Gáspár, R., Mátyus, L., Damjanovich, S., Panyi, G.: Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells.
Biophys. J. Abstr. 86 (1), 540A, 2004.

Somodi, S., Varga, Z., Hajdu, P., Starkus, J., Levy, D., Gáspár, R., Panyi, G.: pH-dependent modulation of Kv1.3 inactivation: role of His399.
Am. J. Physiol. Cell Physiol. 287 (4), C1067-C1076, 2004.

Hajdu, P., Varga, Z., Pieri, C., Panyi, G., Gáspár, R.: Cholesterol modifies the gating of Kv1.3 in human T lymphocytes.
Pflügers Arch. 445 (6), 674-682, 2003.

Somodi, S., Hajdu, P., Varga, Z., Gáspár, R., Panyi, G.: C-type inactivation of Kv1.3 channels: combined effects of extracellular pH,K+ concentration and ionic strength.
Biophys. J. 84 (2), B240, 2003.

Starkus, J., Varga, Z., Schönherr, R., Heinemann, S.: Mechanisms of the inhibition of Shaker potassium channels by protons.
Pflügers Arch. 447 (1), 44-54, 2003.

Varga, Z., Rayner, M., Starkus, J.: Cations affect the rate of gating charge recovery in wild-type and W434F Shaker channels through a variety of mechanisms.
J. Gen. Physiol. 119 (5), 467-485, 2002.

Panyi, G., Somodi, S., Varga, Z., Hajdu, P., Pieri, C., Pandi-Perumal, S., Damjanovich, S., Gáspár, R., Hardar, C., Singaravel, M., Maitra, S.: Pharmacological effects of melatonin on ion channels.
In: Treatise on Pineal Gland and Melatonin, Science Publishers Inc., Enfield, USA, 489-506, 2002.

Péter, M., Varga, Z., Hajdu, P., Gáspár, R., Damjanovich, S., Horjales, E., Possani, L., Panyi, G.: Effects of toxins Pi2 and Pi3 on human T lymphocyte Kv1.3 channels: the role of Glu7 and Lys24.
J. Membr. Biol. 179 (1), 13-25, 2001.

Varga, Z., Panyi, G., Péter, M., Pieri, C., Csécsei, G., Damjanovich, S., Gáspár, R.: Multiple Binding Sites for Melatonin on Kv1.3.
Biophys. J. 80 (3), 1280-1297, 2001.

Péter, M., Hajdu, P., Varga, Z., Damjanovich, S., Possani, L., Panyi, G., Gáspár, R.: Blockage of human T lymphocyte Kv1.3 channels by Pi1, a novel class of scorpion toxin.
Biochem. Biophys. Res. Commun. 278 (1), 34-37, 2000.

Berecki, G., Varga, Z., Iren, F., Duijn, B.: Anion channels in chara corallina tonoplast membrane: calcium dependence and rectification.
J. Membr. Biol. 172 (2), 159-168, 1999.

Gáspár, R., Varga, Z., Panyi, G., Krasznai, Z., Pieri, C., Damjanovich, S.: Measurement and analysis of different aspects of potassium currents in human lymphocytes.
In: Signal Transduction. Single cell techniques. Eds.: Bert van Duijn; Anneke Wiltink, Springer-Verlag, Berlin, Heidelberg, New York, 214-235, 1998.

Péter, M., Varga, Z., Panyi, G., Bene, L., Damjanovich, S., Pieri, C., Possani, L., Gáspár, R.: Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes.
Biochem. Biophys. Res. Commun. 242 (3), 621-625, 1998.

Péter, M., Varga, Z., Krasznai, Z., Panyi, G., Gáspár, R.: Recording and analysis of membrane potential and ion currents in cultured peripheral human lymphocytes.
In: Practical guide to physical analysis of cell surface receptors. Eds.: Krasznai Z., Mátyus L, : Department of Biophysics and Cell Biology, University Medical Scool of Debrecen, Debrecen, 1-16, 1998.

Gáspár, R., Varga, Z., Bene, L., Marcheselli, F., Pieri, C., Damjanovich, S.: Effect of acetylcholine on the electrophysiology and proliferative response of human lymphocytes.
Biochem. Biophys. Res. Commun. 226 (2), 303-308, 1996.

Varga, Z., Bene, L., Pieri, C., Damjanovich, S., Gáspár, R.: The Effect of Juglone on the Membrane Potential and Whole-Cell K+Currents of Human Lymphocytes.
Biochem. Biophys. Res. Commun. 218 (3), 828-832, 1996.