Tudóstér: Kovács Árpád publikációi

Kovács, Á.: Az új jelszó a csökkent ejekciós frakcióval járó szívelégtelenség bázisterápiájában: ASAP!.
Cardiol. Hung. 53 (5), 502-506, 2023.

Zhazykbayeva, S., Hassoun, R., Herwig, M., Budde, H., Kovács, Á., Mannherz, H., El-Battrawy, I., Tóth, A., Schmidt, W., Mügge, A., Hamdani, N.: Oxidative stress and inflammation distinctly drive molecular mechanisms of diastolic dysfunction and remodeling in female and male heart failure with preserved ejection fraction rats.
Front. Cardiovasc. Med. 10 1-14, 2023.

Kovács, Á., Barta, J.: Renin-Angiotensin-Aldosterone System as an Old New Target in Heart Failure Therapy: RAAS Inhibition in Heart Failure.
In: The Renin Angiotensin System in Cardiovascular Disease. Eds.: Naranjan S. Dhalla, Sukhwinder K. Bhullar, Anureet K. Shah, Springer, New York, 307-330, 2023, (Advances in Biochemistry in Health and Disease, ISSN 2512-2142 ; 24)

Gömöri, K., Herwig, M., Hassoun, R., Budde, H., Mostafi, N., Delalat, S., Modi, S., Begovic, M., Szabados, T., Pipis, J., Farkas-Morvay, N., Leprán, I., Kovács, Á., Mügge, A., Ferdinándy, P., Görbe, A., Bencsik, P., Hamdani, N.: Altered Cellular Protein Quality Control System Modulates Cardiomyocyte Function in Volume Overload-Induced Hypertrophy.
Antioxidants. 11 (11), 1-16, 2022.

Gömöri, K., Herwig, M., Budde, H., Hassoun, R., Mostafi, N., Zhazykbayeva, S., Sieme, M., Modi, S., Szabados, T., Pipis, J., Farkas-Morvay, N., Leprán, I., Ágoston, G., Baczkó, I., Kovács, Á., Mügge, A., Ferdinándy, P., Görbe, A., Bencsik, P., Hamdani, N.: Ca2+/calmodulin-dependent protein kinase II and protein kinase G oxidation contributes to impaired sarcomeric proteins in hypertrophy model.
ESC Heart Failure. 9 (4), 2585-2600, 2022.

Budde, H., Hassoun, R., Mügge, A., Kovács, Á., Hamdani, N.: Current Understanding of Molecular Pathophysiology of Heart Failure With Preserved Ejection Fraction.
Front. Physiol. 13 1-18, 2022.

Hassoun, R., Budde, H., Zhazykbayeva, S., Herwig, M., Sieme, M., Delalat, S., Mostafi, N., Gömöri, K., Tangos, M., Jarkas, M., Pabel, S., Bruckmüller, S., Skrygan, M., Lódi, M., Jaquet, K., Sequeira, V., Gambichler, T., Remedios, C., Kovács, Á., Mannherz, H., Mügge, A., Sossalla, S., Hamdani, N.: Do they come together? Protein quality control, stress-activated signaling, and "sarcostat" in hypertrophic cardiomyopathy progression.
Int. J. Cardiol. 347 44-45, 2022.

Priksz, D., Lampé, N., Kovács, Á., Herwig, M., Bombicz, M., Varga, B., Wilisicz, T., Szilvássy, J., Pósa, A., Kiss, R., Gesztelyi, R., Ráduly, A., Szekeres, R., Sieme, M., Papp, Z., Tóth, A., Hamdani, N., Szilvássy, Z., Juhász, B.: Nicotinic-acid derivative BGP-15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy.
Br. J. Pharmacol. 179 (10), 2240-2258, 2022.

Tangos, M., Budde, H., Kolijn, D., Sieme, M., Zhazykbayeva, S., Lódi, M., Herwig, M., Gömöri, K., Hassoun, R., Robinson, E., Meister, T., Jaquet, K., Kovács, Á., Mustroph, J., Evert, K., Babel, N., Fagyas, M., Lindner, D., Püschel, K., Westermann, D., Mannherz, H., Paneni, F., Pfaender, S., Tóth, A., Mügge, A., Sossalla, S., Hamdani, N.: SARS-CoV-2 infects human cardiac myocytes promoted by inflammation and oxidative stress.
Int. J. Cardiol. 362 196-205, 2022.

Fagyas, M., Bánhegyi, V., Úri, K., Enyedi, A., Lizanecz, E., Mányiné Siket, I., Mártha, L., Fülöp, G., Radovits, T., Pólos, M., Merkely, B., Kovács, Á., Szilvássy, Z., Ungvári, Z., Édes, I., Csanádi, Z., Boczán, J., Takács, I., Szabó, G., Balla, J., Balla, G., Seferović, P., Papp, Z., Tóth, A.: Changes in the SARS-CoV-2 cellular receptor ACE2 levels in cardiovascular patients: a potential biomarker for the stratification of COVID-19 patients.
GeroScience. 43 (5), 2289-2304, 2021.

Kolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcao-Pires, I., Reusch, P., Linthout, S., Papp, Z., Heerebeek, L., Vecchione, C., Maier, L., Ciccarelli, M., Tschöpe, C., Mügge, A., Bagi, Z., Sossalla, S., Hamdani, N.: Empagliflozin Improves Endothelial and Cardiomyocyte Function in Human Heart Failure With Preserved Ejection Fraction via Reduced Pro-Inflammatory-Oxidative Pathways and Protein Kinase Gα Oxidation.
Cardiovasc. Res. 117 (2), 495-507, 2021.

Pappritz, K., Dong, F., Miteva, K., Kovács, Á., El-Shafeey, M., Kerim, B., O'Flynn, L., Elliman, S., O'Brien, T., Hamdani, N., Tschöpe, C., Linthout, S.: Impact of Syndecan-2-Selected Mesenchymal Stromal Cells on the Early Onset of Diabetic Cardiomyopathy in Diabetic db/db Mice.
Front. Cardiovasc. Med. 8 1-13, 2021.

Kovács, Á., Herwig, M., Budde, H., Delalat, S., Kolijn, D., Bódi, B., Hassoun, R., Tangos, M., Zhazykbayeva, S., Balogh, Á., Czuriga, D., Linthout, S., Tschöpe, C., Dhalla, N., Mügge, A., Tóth, A., Papp, Z., Barta, J., Hamdani, N.: Interventricular Differences of Signaling Pathways-Mediated Regulation of Cardiomyocyte Function in Response to High Oxidative Stress in the Post-Ischemic Failing Rat Heart.
Antioxidants. 10 (6), 1-21, 2021.

Bódi, B., Kovács, Á., Gulyás, H., Mártha, L., Tóth, A., Mátyás, C., Barta, B., Oláh, A., Merkely, B., Radovits, T., Papp, Z.: Long-Term PDE-5A Inhibition Improves Myofilament Function in Left and Right Ventricular Cardiomyocytes through Partially Different Mechanisms in Diabetic Rat Hearts.
Antioxidants. 10 (11), 1-13, 2021.

Pappritz, K., Klein, O., Dong, F., Hamdani, N., Kovács, Á., O'Flynn, L., Elliman, S., O'Brien, T., Tschöpe, C., Linthout, S.: MALDI-IMS as a Tool to Determine the Myocardial Response to Syndecan-2-Selected Mesenchymal Stromal Cell Application in an Experimental Model of Diabetic Cardiomyopathy.
Proteom. Clin. Appl. 15 (1), 1-10, 2021.

Fülöp, G., Oláh, A., Csípő, T., Kovács, Á., Pórszász, R., Veress, R., Horváth, B., Nagy, L., Bódi, B., Fagyas, M., Helgadottir, S., Bánhegyi, V., Juhász, B., Bombicz, M., Priksz, D., Nánási, P., Merkely, B., Édes, I., Csanádi, Z., Papp, Z., Radovits, T., Tóth, A.: Omecamtiv mecarbil evokes diastolic dysfunction and leads to periodic electromechanical alternans.
Basic Res. Cardiol. 116 (1), 24, 2021.

Hassoun, R., Budde, H., Zhazykbayeva, S., Herwig, M., Sieme, M., Delalat, S., Mostafi, N., Gömöri, K., Tangos, M., Jarkas, M., Pabel, S., Bruckmüller, S., Skrygan, M., Lódi, M., Jaquet, K., Sequeira, V., Gambichler, T., Remedios, C., Kovács, Á., Mannherz, H., Mügge, A., Sossalla, S., Hamdani, N.: Stress activated signalling impaired protein quality control pathways in human hypertrophic cardiomyopathy.
Int. J. Cardiol. 344 160-169, 2021.

Budde, H., Hassoun, R., Tangos, M., Zhazykbayeva, S., Herwig, M., Varatnitskaya, M., Sieme, M., Delalat, S., Sultana, I., Kolijn, D., Gömöri, K., Jarkas, M., Lódi, M., Jaquet, K., Kovács, Á., Mannherz, H., Sequeira, V., Mügge, A., Leichert, L., Sossalla, S., Hamdani, N.: The Interplay between S-Glutathionylation and Phosphorylation of Cardiac Troponin I and Myosin Binding Protein C in End-Stage Human Failing Hearts.
Antioxidants. 10 (7), 1-26, 2021.

Reil, J., Reil, G., Kovács, Á., Sequeira, V., Waddingham, M., Lódi, M., Herwig, M., Ghaderi, S., Kreusser, M., Papp, Z., Voigt, N., Dobrev, D., Meyhöfer, S., Langer, H., Maier, L., Linz, D., Mügge, A., Hohl, M., Steendijk, P., Hamdani, N.: CaMKII Activity Contributes to Homeometric Autoregulation of the Heart: a Novel Mechanism for the Anrep Effect.
J. Physiol.-London. 598 (15), 3129-3153, 2020.

Kolijn, D., Kovács, Á., Herwig, M., Lódi, M., Sieme, M., Alhaj, A., Sandner, P., Papp, Z., Reusch, P., Haldenwang, P., Falcao-Pires, I., Linke, W., Jaquet, K., Linthout, S., Mügge, A., Tschöpe, C., Hamdani, N.: Enhanced Cardiomyocyte Function in Hypertensive Rats With Diastolic Dysfunction and Human Heart Failure Patients After Acute Treatment With Soluble Guanylyl Cyclase (sGC) Activator.
Front. Physiol. 11 1-21, 2020.

Herwig, M., Kolijn, D., Lódi, M., Hölper, S., Kovács, Á., Papp, Z., Jaquet, K., Haldenwang, P., Dos Remedios, C., Reusch, P., Mügge, A., Krüger, M., Fielitz, J., Linke, W., Hamdani, N.: Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D.
Front. Physiol. 11 240, 2020.

Lódi, M., Bánhegyi, V., Bódi, B., Gyöngyösi, A., Kovács, Á., Árokszállási, A., Hamdani, N., Fagyas, M., Édes, I., Csanádi, Z., Czuriga, I., Kisvárday, Z., Lekli, I., Bai, P., Tóth, A., Papp, Z., Czuriga, D.: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy.
J. Transl. Med. 18 (1), 470, 2020.

Lódi, M., Priksz, D., Fülöp, G., Bódi, B., Gyöngyösi, A., Nagy, L., Kovács, Á., Kertész, A., Kocsis, J., Édes, I., Csanádi, Z., Czuriga, I., Kisvárday, Z., Juhász, B., Lekli, I., Bai, P., Tóth, A., Papp, Z., Czuriga, D.: Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy.
J. Transl. Med. 17 229, 2019.

Pabel, S., Wagner, S., Bollenberg, H., Bengel, P., Kovács, Á., Schach, C., Tirilomis, P., Mustroph, J., Renner, A., Gummert, J., Fischer, T., Linthout, S., Tschöpe, C., Streckfuss-Bömeke, K., Hasenfuß, G., Maier, L., Hamdani, N., Sossalla, S.: Empagliflozin directly improves diastolic function in human heart failure.
Eur. J. Heart Fail. 20 (12), 1690-1700, 2018.

Nagy, L., Gődény, I., Nánási, P., Leskó, Á., Balogh, L., Bánhegyi, V., Bódi, B., Csípő, T., Csongrádi, A., Fülöp, G., Kovács, Á., Lódi, M., Papp, Z.: A szív pozitív inotróp támogatása a miozin-aktivátor hatású omecamtiv-mecarbil segítségével.
Cardiol. Hung. 47 (1), 69-76, 2017.

Szokol, M., Priksz, D., Bombicz, M., Varga, B., Kovács, Á., Fülöp, G., Csípő, T., Pósa, A., Tóth, A., Papp, Z., Szilvássy, Z., Juhász, B.: Long term osmotic mini pump treatment with alpha-MSH improves myocardial function in Zucker Diabetic Fatty rats.
Molecules. 22 (10), 1-18, 2017.

Kovács, Á., Kalász, J., Pásztorné Tóth, E., Tóth, A., Papp, Z., Dhalla, N., Barta, J.: Myosin heavy chain and cardiac troponin T damage is associated with impaired myofibrillar ATPase activity contributing to sarcomeric dysfunction in Ca2+-paradox rat hearts.
Mol. Cell. Biochem. 403 (1-2), 57-68, 2017.

Bódi, B., Pásztorné Tóth, E., Nagy, L., Tóth, A., Mártha, L., Kovács, Á., Balla, G., Kovács, T., Papp, Z.: Titin isoforms are increasingly protected against oxidative modifications in developing rat cardiomyocytes.
Free Radic. Biol. Med. 113 224-235, 2017.

Kovács, Á., Alogna, A., Post, H., Hamdani, N.: Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?.
Neth. Heart. J. 24 (4), 268-274, 2016.

Kovács, Á., Fülöp, G., Kovács, A., Csípő, T., Bódi, B., Priksz, D., Juhász, B., Beke, L., Hendrik, Z., Méhes, G., Granzier, H., Édes, I., Fagyas, M., Papp, Z., Barta, J., Tóth, A.: Renin overexpression leads to increased titin-based stiffness contributing to diastolic dysfunction in hypertensive mRen2 rats.
Am. J. Physiol.-Heart Circul. Physiol. 310 (11), H1671-H1682, 2016.

Barta, J., Kovács, Á.: Szívelégtelenség és cilostazol.
Cardiol. Hung. 45 (2), 108-116, 2015.

Nagy, L., Kovács, Á., Bódi, B., Pásztorné Tóth, E., Fülöp, G., Tóth, A., Édes, I., Papp, Z.: The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat.
Br. J. Pharmacol. 172 (18), 4506-4518, 2015.

Kovács, Á., Papp, Z., Nagy, L.: Causes and pathophysiology of heart failure with preserved ejection fraction.
Heart Fail. Clin. 10 (3), 389-398, 2014.

Balogh, Á., Tóth, A., Pásztorné Tóth, E., Nagy, L., Kovács, Á., Kalász, J., Contreras, G., Édes, I., Papp, Z.: Myofilament carbonylation modulates contractility in human cardiomyocytes.
Exp. Clin. Cardiol. 20 (1), 2026-2035, 2014.