Tudóstér: Szabó András publikációi

Hoffka, G., Mhana, S., Vas, M., Toldi, V., Mótyán, J., Tőzsér, J., Szabó, A.: Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog.
J. Biol. Chem. [Epub ahead of print]2024.

Morales Granda, N., Toldi, V., Miczi, M., Lassoued, M., Szabó, A.: Inhibition of mouse trypsin isoforms by SPINK1 and effect of human pancreatitis-associated mutations.
Pancreatology. 23 (4), 358-366, 2023.

Kassay, N., Toldi, V., Tőzsér, J., Szabó, A.: Cigarette smoke toxin hydroquinone and misfolding pancreatic lipase variant cooperatively promote endoplasmic reticulum stress and cell death.
PLoS One. 17 (6), 1-19, 2022.

Szabó, A., Toldi, V., Gazda, L., Demcsák, A., Tőzsér, J., Sahin-Tóth, M.: Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis.
J. Biol. Chem. 296 1-13, 2021.

Toldi, V., Kassay, N., Szabó, A.: Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress.
Pancreatology. 21 (7), 1317-1325, 2021.

Toldi, V., Szabó, A., Sahin-Tóth, M.: Inactivation of mesotrypsin by chymotrypsin C prevents trypsin inhibitor degradation.
J. Biol. Chem. 295 (11), 3447-3455, 2020.

Esteghamat, F., Broughton, J., Smith, E., Cardone, R., Tyagi, T., Guerra, M., Szabó, A., Ugwu, N., Mani, M., Azari, B., Kayingo, G., Chung, S., Fathzadeh, M., Weiss, E., Bender, J., Mane, S., Lifton, R., Adeniran, A., Nathanson, M., Gorelick, F., Hwa, J., Sahin-Tóth, M., Belfort-DeAguiar, R., Kibbey, R., Mani, A.: CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation.
Nature Genet. 51 (8), 1233-1243, 2019.

Lasher, D., Szabó, A., Masamune, A., Chen, J., Xiao, X., Whitcomb, D., Barmada, M., Ewers, M., Ruffert, C., Paliwal, S., Issarapu, P., Bhaskar, S., Mani, K., Chandak, G., Laumen, H., Masson, E., Kume, K., Hamada, S., Nakano, E., Seltsam, K., Bugert, P., Müller, T., Groneberg, D., Shimosegawa, T., Rosendahl, J., Férec, C., Lowe, M., Witt, H., Sahin-Tóth, M.: Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.
Am. J. Gastroenterol. 114 (6), 974-983, 2019.

Tóth, A., Szabó, A., Hegyi, E., Hegyi, P., Sahin-Tóth, M.: Detection of human elastase isoforms by the ScheBo pancreatic elastase 1 test.
Am. J. Physiol.-Gastroint. Liver Physiol. 312 (6), G606-G614, 2017.

Boros, E., Szabó, A., Zboray, K., Héja, D., Pál, G., Sahin-Tóth, M.: Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.
J. Biol. Chem. 292 (7), 2690-2702, 2017.

Szabó, A., Pilsak, C., Bence, M., Witt, H., Sahin-Tóth, M.: Complex formation of human proelastases with procarboxypeptidases A1 and A2.
J. Biol. Chem. 291 (34), 17706-17716, 2016.

Szabó, A., Xiao, X., Haughney, M., Spector, A., Sahin-Tóth, M., Lowe, M.: A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.
Biochim. Biophys. Acta. Mol. Basis Dis. 1852 (7), 1372-1379, 2015.

Szabó, A., Ludwig, M., Hegyi, E., Szépeová, R., Witt, H., Sahin-Tóth, M.: Mesotrypsin signature mutation in a chymotrypsin C (CTRC) variant associated with chronic pancreatitis.
J. Biol. Chem. 290 (28), 17282-17292, 2015.

Szabó, A., Salameh, M., Ludwig, M., Radisky, E., Sahin-Tóth, M.: Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.
PLoS One. 9 (7), e102063, 2014.

Szabó, A., Radisky, E., Sahin-Tóth, M.: Zymogen activation confers thermodynamic stability on a key peptide bond and protects human cationic trypsin from degradation.
J. Biol. Chem. 289 (8), 4753-4761, 2014.

Beer, S., Zhou, J., Szabó, A., Keiles, S., Chandak, G., Witt, H., Sahin-Tóth, M.: Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk.
Gut. 62 (11), 1616-1624, 2013.

Batra, J., Szabó, A., Caulfield, T., Soares, A., Sahin-Tóth, M., Radisky, E.: Long-range electrostatic complementarity governs substrate recognition by human chymotrypsin C, a key regulator of digestive enzyme activation.
J. Biol. Chem. 288 (14), 9848-9859, 2013.

Witt, H., Beer, S., Rosendahl, J., Chen, J., Chandak, G., Masamune, A., Bence, M., Szmola, R., Oracz, G., Macek, J., Bhatia, E., Steigenberger, S., Lasher, D., Bühler, F., Delaporte, C., Tebbing, J., Ludwig, M., Pilsak, C., Saum, K., Bugert, P., Masson, E., Paliwal, S., Bhaskar, S., Sobczynska-Tomaszewska, A., Bak, D., Balascak, I., Choudhuri, G., Reddy, D., Rao, G., Thomas, V., Kume, K., Nakano, E., Kakuta, Y., Shimosegawa, T., Durko, L., Szabó, A., Schnúr, A., Hegyi, P., Rakonczay, Z., Pfützer, R., Schneider, A., Groneberg, D., Braun, M., Schmidt, H., Witt, U., Friess, H., Algül, H., Landt, O., Schuelke, M., Krüger, R., Wiedenmann, B., Schmidt, F., Zimmer, K., Kovács, P., Stumvoll, M., Blüher, M., Müller, T., Janecke, A., Teich, N., Grützmann, R., Schulz, H., Mössner, J., Keim, V., Löhr, M., Férec, C., Sahin-Tóth, M.: Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Nature Genet. 45 (10), 1216-1220, 2013.

Szabó, A., Sahin-Tóth, M.: Determinants of chymotrypsin C cleavage specificity in the calcium-binding loop of human cationic trypsinogen.
FEBS J. 279 (23), 4983-4292, 2012.

Szabó, A., Sahin-Tóth, M.: Increased activation of hereditary pancreatitis-associated human cationic trypsinogen mutants in presence of chymotrypsin C.
J. Biol. Chem. 287 (24), 20701-20710, 2012.

Szabó, A., Héja, D., Szakács, D., Zboray, K., Kékesi, K., Radisky, E., Sahin-Tóth, M., Pál, G.: High affinity small protein inhibitors of human chymotrypsin C (CTRC) selected by phage display reveal unusual preference for P4' acidic residues.
J. Biol. Chem. 286 (25), 22535-22545, 2011.

Szmola, R., Bence, M., Carpentieri, A., Szabó, A., Costello, C., Samuelson, J., Sahin-Tóth, M.: Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2.
J. Biol. Chem. 286 (3), 1819-1827, 2010.

Szabó, A., Kotormán, M., Laczkó, I., Simon, L.: Improved stability and catalytic activity of chemically modified papain in aqueous organic solvents.
Process Biochem. 44 (2), 199-204, 2009.

Szabó, A., Kotormán, M., Laczkó, I., Simon, L.: Influence of carbohydrates on stability of papain in aqueous tetrahydrofuran mixture.
J. Chem. Technol. Biotechnol. 84 (1), 133-138, 2009.

Simon, L., Kotormán, M., Szabó, A., Nemcsók, J., Laczkó, I.: The effects of organic solvent/water mixtures on the structure and catalytic activity of porcine pepsin.
Process Biochem. 42 (5), 909-912, 2007.

Szabó, A., Kotormán, M., Laczkó, I., Simon, L.: Spectroscopic studies of stability of papain in aqueous organic solvents.
J. Mol. Catal. B-Enzym. 41 (1-2), 43-48, 2006.

Simon, L., Kotormán, M., Szabó, A., Garab, G., Laczkó, I.: Effects of polyethylene glycol on stability of [alfa]-chymotrypsin in aqueous ethanol solvent.
Biochem. Biophys. Res. Commun. 317 (2), 610-613, 2004.

Kotormán, M., Laczkó, I., Szabó, A., Simon, L.: Effects of Ca2+ on catalytic activity and conformation of trypsin and [alfa]-chymotrypsin in aqueous ethanol.
Biochem. Biophys. Res. Commun. 304 (1), 18-21, 2003.