Tudóstér: Docsa Tibor publikációi

Kun, S., Mathomes, R., Docsa, T., Somsák, L., Hayes, J.: Design and Synthesis of 3-(β-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential.
Molecules. 28 (7), 1-19, 2023.

Kola, J., Docsa, T., Uray, K.: Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract.
Int. J. Mol. Sci. 24 (1), 1-12, 2023.

Kola, J., Turarova, B., Csige, D., Sipos, Á., Varga, L., Gergely, B., Refai, F., Uray, I., Docsa, T., Uray, K.: Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity.
Molecules. 28 (11), 1-14, 2023.

Docsa, T., Sipos, Á., Cox, C., Uray, K.: The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders.
Int. J. Mol. Sci. 23 (13), 1-22, 2022.

Sipos, Á., Szennyes, E., Hajnal, É., Kun, S., Szabó, E., Uray, K., Somsák, L., Docsa, T., Bokor, É.: Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.
Pharmaceuticals. 14 (4), 1-27, 2021.

Docsa, T., Bhattarai, D., Sipos, Á., Wade, C., Cox, C., Uray, K.: CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity.
Neurogastroenterol. Motil. 32 (3), 1-12, 2020.

Goyard, D., Kónya, B., Czifrák, K., Larini, P., Demontrond, F., Leroy, J., Balzarin, S., Tournier, M., Tousch, D., Petit, P., Duret, C., Maurel, P., Docsa, T., Gergely, P., Somsák, L., Praly, J., Azay-Milhau, J., Vidal, S.: Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition.
Org. Biomol. Chem. 18 (5), 931-940, 2020.

Nagy, L., Béke, F., Juhász, L., Kovács, T., Juhász-Tóth, É., Docsa, T., Tóth, A., Gergely, P., Somsák, L., Bai, P.: Glycogen phosphorylase inhibitor, 2,3-bis[(2E)-3-(4-hydroxyphenyl)prop-2-enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells.
PLoS One. 15 (9), 1-15, 2020.

Kun, S., Kánya, N., Galó, N., Páhi, A., Mándi, A., Kurtán, T., Makleit, P., Veres, S., Sipos, Á., Docsa, T., Somsák, L.: Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition.
J. Agric. Food Chem. 67 (24), 6884-6891, 2019.

Szabó, E., Kyriakis, E., Psarra, A., Karra, A., Sipos, Á., Docsa, T., Stravodimos, G., Katsidou, E., Skamnaki, V., Liggri, P., Zographos, S., Mándi, A., Király, S., Kurtán, T., Leonidas, D., Somsák, L.: Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography.
J. Med. Chem. 62 (13), 6116-6136, 2019.

Barr, D., Szennyes, E., Bokor, É., Al-Oanzi, Z., Moffatt, C., Kun, S., Docsa, T., Sipos, Á., Davies, M., Mathomes, R., Snape, T., Agius, L., Somsák, L., Hayes, J.: Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem. Biol. 14 (7), 1460-1470, 2019.

Szennyes, E., Bokor, É., Docsa, T., Sipos, Á., Somsák, L.: Synthesis of C-β-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase.
Carbohydr. Res. 472 33-41, 2019.

Kun, S., Begum, J., Kyriakis, E., Stamati, E., Barkas, T., Szennyes, E., Bokor, É., Szabó, E., Stravodimos, G., Sipos, Á., Docsa, T., Gergely, P., Moffatt, C., Patraskaki, M., Kokolaki, M., Gkerdi, A., Skamnaki, V., Leonidas, D., Somsák, L., Hayes, J.: A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur. J. Med. Chem. 147 266-278, 2018.

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L., Bai, P.: Glycogen phosphorylase inhibition improves beta cell function.
Br. J. Pharmacol. 175 (2), 301-319, 2018.

Kun, S., Bokor, É., Sipos, Á., Docsa, T., Somsák, L.: Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.
Molecules. 23 (3), 1-17, 2018.

Szennyes, E., Bokor, É., Langer, P., Gyémánt, G., Docsa, T., Sipos, Á., Somsák, L.: The first general synthesis of 2-C-(beta-D-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes.
New J. Chem. 42 (21), 17439-17446, 2018.

Bokor, É., Kyriakis, E., Solovou, T., Koppány, C., Kantsadi, A., Szabó, E., Szakács, A., Stravodimos, G., Docsa, T., Skamnaki, V., Zographos, S., Gergely, P., Leonidas, D., Somsák, L.: Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
J. Med. Chem. 60 (22), 9251-9262, 2017.

Bokor, É., Széles, Z., Docsa, T., Gergely, P., Somsák, L.: C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase.
Carbohydr. Res. 429 128-134, 2016.

Goyard, D., Kónya, B., Chajistamatiou, A., Chrysina, E., Leroy, J., Balzarin, S., Tournier, M., Tousch, D., Petit, P., Duret, C., Maurel, P., Somsák, L., Docsa, T., Gergely, P., Praly, J., Azay-Milhau, J., Vidal, S.: Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
Eur. J. Med. Chem. 108 444-454, 2016.

Szennyes, E., Bokor, É., Batta, G., Docsa, T., Gergely, P., Somsák, L.: Improved preparation of 4(5)-aryl-2-(β-D-glucopyranosyl)-imidazoles, the most efficient glucose analogue inhibitors of glycogen phosphorylase.
RSC Adv. 6 (97), 94787-94794, 2016.

Petrušová, M., Smrtičová, H., Pribulová, B., Vlčková, S., Uhliariková, I., Docsa, T., Somsák, L., Petruš, L.: One pot InCl3-catalyzed synthesis of 1-glycosylmethyl-1H-imidazoles.
Tetrahedron. 72 (17), 2116-2121, 2016.

Kantsadi, A., Bokor, É., Kun, S., Stravodimos, G., Chatzileontiadou, D., Leonidas, D., Juhász-Tóth, É., Szakács, A., Batta, G., Docsa, T., Gergely, P., Somsák, L.: Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Eur. J. Med. Chem. 123 737-745, 2016.

Donnier-Maréchal, M., Goyard, D., Folliard, V., Docsa, T., Gergely, P., Praly, J., Vidal, S.: 3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors.
Beilstein J. Org. Chem. 11 499-503, 2015.

Bokor, É., Kun, S., Docsa, T., Gergely, P., Somsák, L.: 4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS Med. Chem. Lett. 6 1215-1219, 2015.

Bokor, É., Szennyes, E., Csupász, T., Tóth, N., Docsa, T., Gergely, P., Somsák, L.: C-(2-Deoxy-D-arabino-hex-1-enopyranosyl)-oxadiazoles: synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors.
Carbohydr. Res. 412 71-79, 2015.

Begum, J., Varga, G., Docsa, T., Gergely, P., Hayes, J., Juhász, L., Somsák, L.: Computationally motivated synthesis and enzyme kinetic evaluation of N-([beta]-D-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors.
Med. Chem. Commun. 6 (1), 80-89, 2015.

Docsa, T., Marics, B., Németh, J., Hüse, C., Somsák, L., Gergely, P., Peitl, B.: Insulin sensitivity is modified by a glycogen phosphorylase inhibitor: glucopyranosylidene-spiro-thiohydantoin in streptozotocin-induced diabetic rats.
Curr. Top. Med. Chem. 15 (23), 2390-2394, 2015.

Goyard, D., Docsa, T., Gergely, P., Praly, J., Vidal, S.: Synthesis of 4-amidomethyl-1-glucosyl-1,2,3-triazoles and evaluation as glycogen phosphorylase inhibitors.
Carbohydr. Res. 402 245-251, 2015.

Czifrák, K., Páhi, A., Deák, S., Kiss-Szikszai, A., Kövér, K., Docsa, T., Gergely, P., Alexacou, K., Papakonstantinou, M., Leonidas, D., Zographos, S., Chrysina, E., Somsák, L.: Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods.
Bioorg. Med. Chem. 22 (15), 4028-4041, 2014.

Kun, S., Bokor, É., Varga, G., Szőcs, B., Páhi, A., Czifrák, K., Tóth, M., Juhász, L., Docsa, T., Gergely, P., Somsák, L.: New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4- triazoles, nanomolar inhibitors of glycogen phosphorylase.
Eur. J. Med. Chem. 76 567-579, 2014.

Juhász, L., Varga, G., Sztankovics, A., Béke, F., Docsa, T., Kiss-Szikszai, A., Gergely, P., Kóňa, J., Tvaroška, I., Somsák, L.: Structure-activity relationships of glycogen phosphorylase inhibitor FR258900 and its analogues: a combined synthetic, enzyme kinetics, and computational study.
ChemPlusChem. 79 (11), 1558-1568, 2014.

Somsák, L., Bokor, É., Czibere, B., Czifrák, K., Koppány, C., Kulcsár, L., Kun, S., Szilágyi, E., Tóth, M., Docsa, T., Gergely, P.: Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase.
Carbohydr. Res. 399 38-48, 2014.

Bokor, É., Docsa, T., Gergely, P., Somsák, L.: C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
ACS Med. Chem. Lett. 4 (7), 612-615, 2013.

Nagy, L., Docsa, T., Szántó, M., Brunyánszki, A., Hegedűs, C., Márton, J., Kónya, B., Virág, L., Somsák, L., Gergely, P., Bai, P.: Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N'-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism.
PLoS One. 8 (7), e69420-, 2013.

Polyák, M., Varga, G., Szilágyi, B., Juhász, L., Docsa, T., Gergely, P., Begum, J., Hayes, J., Somsák, L.: Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
Bioorg. Med. Chem. 21 (18), 5738-5747, 2013.

Szőcs, B., Tóth, M., Docsa, T., Gergely, P., Somsák, L.: Synthesis of 2-(β-D-glucopyranosyl)-5-(substituted-amino)-1,3,4-oxa-and -thiadiazoles for the inhibition of glycogen phosphorylase.
Carbohydr. Res. 381C 187-195, 2013.

Tóth, M., Szőcs, B., Kaszás, T., Docsa, T., Gergely, P., Somsák, L.: Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase.
Carbohydr. Res. 381C 196-204, 2013.

Bokor, É., Szilágyi, E., Docsa, T., Gergely, P., Somsák, L.: Synthesis of substituted 2-(β-d-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.
Carbohydr. Res. 381C 179-186, 2013.

Varga, G., Docsa, T., Gergely, P., Juhász, L., Somsák, L.: Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors.
Bioorg. Med. Chem. Lett. 23 (6), 1789-1792, 2013.

Nagy, V., Felföldi, N., Kónya, B., Praly, J., Docsa, T., Gergely, P., Chrysina, E., Tiraidis, C., Kosmopoulou, M., Alexacou, K., Konstantakaki, M., Leonidas, D., Zographos, S., Oikonomakos, N., Kozmon, S., Tvaroška, I., Somsák, L.: N-(4-Substituted-benzoyl)-N'-(beta-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.
Bioorg. Med. Chem. 20 (5), 1801-1816, 2012.

Goyard, D., Baron, M., Skourti, P., Chajistamatiou, A., Docsa, T., Gergely, P., Chrysina, E., Praly, J., Vidal, S.: Synthesis of 1,2,3-triazoles from xylosyl and 5-thioxylosyl azides: evaluation of the xylose scaffold for the design of potential glycogen phosphorylase inhibitors.
Carbohydr. Res. 364 28-40, 2012.

Kónya, B., Docsa, T., Gergely, P., Somsák, L.: Synthesis of heterocyclic N-(beta-d-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase.
Carbohydr. Res. 351 56-63, 2012.

Tite, T., Loic, T., Docsa, T., Gergely, P., Kovensky, J., Gueyrard, D., Wadouachi, A.: Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors.
Tetrahedron Lett. 53 (8), 959-961, 2012.

Docsa, T., Czifrák, K., Hüse, C., Somsák, L., Gergely, P.: Effect of glucopyranosylidene-spiro-thiohydantoin on glycogen metabolism in liver tissues of streptozotocin-induced and obese diabetic rats.
Mol. Med. Rep. 4 (3), 477-481, 2011.

Kun, S., Nagy, G., Tóth, M., Czecze, L., Van Nhien, A., Docsa, T., Gergely, P., Charavgi, M., Skourti, P., Chrysina, E., Patonay, T., Somsák, L.: Synthesis of variously coupled conjugates of d-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.
Carbohydr. Res. 346 (12), 1427-1438, 2011.

Czakó, Z., Docsa, T., Gergely, P., Juhász, L., Antus, S.: Synthesis and glycogen phosphorylase inhibitor activity of funtionalized 1,4-benzodioxanes.
Pharmazie. 65 (4), 235-238, 2010.

Bokor, É., Docsa, T., Gergely, P., Somsák, L.: Synthesis of 1-(D-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors.
Bioorg. Med. Chem. 18 (3), 1171-1180, 2010.

Cheng, K., Liu, J., Sun, H., Bokor, É., Czifrák, K., Kónya, B., Tóth, M., Docsa, T., Gergely, P., Somsák, L.: Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase.
New J. Chem. 34 1450-1464, 2010.

Nagy, V., Benltifa, M., Vidal, S., Berzsényi, E., Teilhet, C., Czifrák, K., Batta, G., Docsa, T., Gergely, P., Somsák, L., Praly, J.: Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase.
Bioorg. Med. Chem. 17 (15), 5696-5707, 2009.

Cecioni, S., Argintaru, O., Praly, J., Vidal, S., Docsa, T., Gergely, P.: Probing multivalency for the inhibition of an enzyme: glycogen phosphorylase as a case study.
New J. Chem. 33 (1), 148-156, 2009.

Czakó, Z., Juhász, L., Kenéz, Á., Czifrák, K., Somsák, L., Docsa, T., Gergely, P., Antus, S.: Synthesis and glycogen phosphorylase inhibitory activity of N-(beta-D-glucopyranosyl)amides possessing 1,4-benzodioxane moiety.
Bioorg. Med. Chem. 17 (18), 6738-6741, 2009.

Tóth, M., Kun, S., Bokor, É., Benltifa, M., Tallec, G., Vidal, S., Docsa, T., Gergely, P., Somsák, L., Praly, J.: Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorg. Med. Chem. 17 (13), 4773-4785, 2009.

Bertus, P., Szymoniak, J., Jeanneau, E., Docsa, T., Gergely, P., Praly, J., Vidal, S.: Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor.
Bioorg. Med. Chem. Lett. 18 (17), 4774-4778, 2008.

Juhász, L., Docsa, T., Brunyánszki, A., Gergely, P., Antus, S.: Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives.
Bioorg. Med. Chem. 15 (12), 4048-4056, 2007.

Anagnostou, E., Kosmopoulou, M., Chrysina, E., Leonidas, D., Hadjiloi, T., Tiraidis, C., Zographos, S., Györgydeák, Z., Somsák, L., Docsa, T., Gergely, P., Kolisis, F., Oikonomakos, G.: Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase.
Bioorg. Med. Chem. 14 (1), 181-189, 2006.

Benltifa, M., Vidal, S., Fenet, B., Msaddek, M., Goekjian, P., Praly, J., Brunyánszki, A., Docsa, T., Gergely, P.: In search of glycogen phosphorylase inhibitors: 5-substituted 3-C-glucopyranosyl-1,2,4-oxadiazoles from beta-D-glucopyranosyl cyanides upon cyclization of O-acylamidoxime intermediates.
European J. Org. Chem. 2006 (18), 4242-4256, 2006.

Czifrák, K., Hadady, Z., Docsa, T., Gergely, P., Schmidt, J., Wessjohann, L., Somsák, L.: Synthesis of N-(beta-D-glucopyranosyl) monoamides of dicarboxylic acids as potential inhibitors of glycogen phosphorylase.
Carbohydr. Res. 341 (8), 947-956, 2006.

Chrysina, E., Kosmopoulou, M., Tiraidis, C., Kardakaris, R., Bischler, N., Leonidas, D., Hadady, Z., Somsák, L., Docsa, T., Gergely, P., Oikonomakos, N.: Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site.
Protein Sci. 14 (4), 873-888, 2005.

Somsák, L., Nagy, V., Hadady, Z., Felföldi, N., Docsa, T., Gergely, P.: Recent developments in the synthesis and evaluation of glucose analog inhibitors of glycogen phosphorylase as potential antidiabetic agents.
In: Frontiers in Medicinal Chemistry - Online. Eds.: Allen B. Reitz, Atta-ur-Rahman, Bentham Science Publisher, Netherlands, 253-272, 2005.

Györgydeák, Z., Hadady, Z., Felföldi, N., Krakomperger, A., Nagy, V., Tóth, M., Brunyánszki, A., Docsa, T., Gergely, P., Somsák, L.: Synthesis of N-(beta-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-beta-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase.
Bioorg. Med. Chem. 12 (18), 4861-4870, 2004.

Chrysina, E., Oikonomakos, N., Zographos, S., Kosmopoulou, M., Bischler, N., Leonidas, D., Kovács, L., Docsa, T., Gergely, P., Somsák, L.: Crystallographic studies on α- and β-D-glucopyranosyl formamide analogues, inhibitors of glycogen phosphorylase.
Biocatal. Biotransform. 21 (4-5), 233-242, 2003.

Somsák, L., Nagy, V., Hadady, Z., Docsa, T., Gergely, P.: Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: recent developments.
Curr. Pharm. Des. 9 (15), 1177-1189, 2003.

Oikonomakos, N., Kosmopoulou, M., Zographos, S., Leonidas, D., Chrysina, E., Somsák, L., Nagy, V., Praly, J., Docsa, T., Tóth, B., Gergely, P.: Binding of N-acetyl-N'-β-D-glucopyranosyl urea and N-benzoyl-N'-β-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies.
Eur. J. Biochem. 269 (6), 1684-1696, 2002.

Oikonomakos, N., Skamnaki, V., Ősz, E., Szilágyi, L., Somsák, L., Docsa, T., Tóth, B., Gergely, P.: Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B.
Bioorg. Med. Chem. 10 (2), 261-268, 2002.

Docsa, T., Somsák, L., Tóth, B., Gergely, P.: Effect of glucopyranosylidene-spiro-thiohydantoin on the enzymes of hepatic glycogen metabolism in rats.
In: Protein Modules in Cellular Signalling. Ed.: by Ludwig Heilmeyer, Peter Friedrich, IOS Press, Amsterdam, 142-149, 2001. ISBN: 1586031805

Somsák, L., Kovács, L., Tóth, M., Ősz, E., Szilágyi, L., Györgydeák, Z., Dinya, Z., Docsa, T., Tóth, B., Gergely, P.: Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of D-Gluco- and D-Xylopyranosylidene-spiro-(thio)hydantoins and N-(D-Glucopyranosyl) amides.
J. Med. Chem. 44 (17), 2843-2848, 2001.

Somsák, L., Nagy, V., Docsa, T., Tóth, B., Gergely, P.: Gram-scale synthesis of a glucopyranosylidene-spiro-thiohydantoin and its effect on hepatic glycogen metabolism studied in vitro and in vivo.
Tetrahedron Asymmetry. 11 405-408, 2000.

Docsa, T., Tar, K., Tóth, B., Somsák, L., Gergely, P.: Regulation of hepatic glycogen metabolism by glycopyranosylidene-spiro-thiohydantoin.
J. Physiol.-London. 5262000.

Ősz, E., Somsák, L., Szilágyi, L., Kovács, L., Docsa, T., Tóth, B., Gergely, P.: Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin.
Bioorg. Med. Chem. Lett. 9 (10), 1385-1390, 1999.