Tudóstér: Kun Sándor publikációi

Kun, S., Mathomes, R., Docsa, T., Somsák, L., Hayes, J.: Design and Synthesis of 3-(β-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential.
Molecules. 28 (7), 1-19, 2023.

Kánya, N., Kun, S., Somsák, L.: Glycopyranosylidene-Spiro-Morpholinones: Evaluation of the Synthetic Possibilities Based on Glyculosonamide Derivatives and a New Method for the Construction of the Morpholine Ring.
Molecules. 27 (22), 1-18, 2022.

Sipos, Á., Szennyes, E., Hajnal, É., Kun, S., Szabó, E., Uray, K., Somsák, L., Docsa, T., Bokor, É.: Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.
Pharmaceuticals. 14 (4), 1-27, 2021.

Tsagkarakou, A., Chasapi, S., Koulas, S., Tsialtas, I., Kyriakis, E., Drakou, C., Kun, S., Somsák, L., Spyroulias, G., Psarra, A., Leonidas, D.: Structure activity relationship of the binding of p-coumaroyl glucose to glycogen phosphorylase and its effect on hepatic cell metabolic pathways.
European Journal of Medicinal Chemistry Reports. 3 1-11, 2021.

Gorliczay, E., Tamás, J., Kun, S., Huzsvai, L., Bárány, L.: Examination and statistical evaluation of physico-chemical parameters of windrow composting.
Agrártud. Közl. 1 33-38, 2020.

Kánya, N., Kun, S., Batta, G., Somsák, L.: Glycosylation with ulosonates under Mitsunobu conditions: scope and limitations.
New J. Chem. 44 (34), 14463-14476, 2020.

Kiss, N., Nagy, P., Tóth, F., Gorliczay, E., Madar, L., Kun, S., Tamás, J.: Improving the water management properties of different soil type.
In: A klímaváltozás kihívásai a következő évtizedekben : előadások kivonatai, Szent István Egyetem, Keszthely, 54, 2020.

Kyriakis, E., Karra, A., Papaioannou, O., Solovou, T., Skamnaki, V., Liggri, P., Zographos, S., Szennyes, E., Bokor, É., Kun, S., Psarra, A., Somsák, L., Leonidas, D.: The architecture of hydrogen and sulfur α-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Bioorg. Med. Chem. 28 (1), 1-10, 2020.

Kun, S., Kánya, N., Galó, N., Páhi, A., Mándi, A., Kurtán, T., Makleit, P., Veres, S., Sipos, Á., Docsa, T., Somsák, L.: Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition.
J. Agric. Food Chem. 67 (24), 6884-6891, 2019.

Barr, D., Szennyes, E., Bokor, É., Al-Oanzi, Z., Moffatt, C., Kun, S., Docsa, T., Sipos, Á., Davies, M., Mathomes, R., Snape, T., Agius, L., Somsák, L., Hayes, J.: Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem. Biol. 14 (7), 1460-1470, 2019.

Somsák, L., Bokor, É., Juhász, L., Kun, S., Lázár, L., Juhász-Tóth, É., Tóth, M.: New syntheses towards C-glycosyl type glycomimetics.
Pure Appl. Chem. 91 (7), 1159-1175, 2019.

Körhegyi, Z., Rózsa, D., Hajdu, I., Bodnár, M., Kertész, I., Kerekes, K., Kun, S., Kollár, J., Varga, J., Garai, I., Trencsényi, G., Borbély, J.: Synthesis of 68Ga-Labeled Biopolymer-based Nanoparticle Imaging Agents for Positron-emission Tomography.
Anticancer Res. 39 (5), 2415-2427, 2019.

Kun, S., Begum, J., Kyriakis, E., Stamati, E., Barkas, T., Szennyes, E., Bokor, É., Szabó, E., Stravodimos, G., Sipos, Á., Docsa, T., Gergely, P., Moffatt, C., Patraskaki, M., Kokolaki, M., Gkerdi, A., Skamnaki, V., Leonidas, D., Somsák, L., Hayes, J.: A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur. J. Med. Chem. 147 266-278, 2018.

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L., Bai, P.: Glycogen phosphorylase inhibition improves beta cell function.
Br. J. Pharmacol. 175 (2), 301-319, 2018.

Kyriakis, E., Solovou, T., Kun, S., Czifrák, K., Szőcs, B., Juhász, L., Bokor, É., Stravodimos, G., Kantsadi, A., Chatzileontiadou, D., Skamnaki, V., Somsák, L., Leonidas, D.: Probing the [beta]-pocket of the active site of human liver glycogen phosphorylase with 3-(C-[beta]-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
Bioorganic Chem. 77 485-493, 2018.

Kun, S., Bokor, É., Sipos, Á., Docsa, T., Somsák, L.: Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.
Molecules. 23 (3), 1-17, 2018.

Bokor, É., Kun, S., Goyard, D., Tóth, M., Praly, J., Vidal, S., Somsák, L.: C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential.
Chem. Rev. 117 (3), 1687-1764, 2017.

Kaszás, T., Tóth, M., Kun, S., Somsák, L.: Coupling of anhydro-aldose tosylhydrazones with hydroxy compounds and carboxylic acids: a new route for the synthesis of C-b-D-glycopyranosylmethyl ethers and esters.
RSC Adv. 7 10454-10462, 2017.

Szabó, E., Kun, S., Mándi, A., Kurtán, T., Somsák, L.: Glucopyranosylidene-Spiro-Thiazolinones: Synthetic Studies and Determination of Absolute Configuration by TDDFT-ECD Calculations.
Molecules. 22 (10), 1760-1774, 2017.

Kantsadi, A., Stravodimos, G., Kyriakis, E., Chatzileontiadou, D., Solovou, T., Kun, S., Bokor, É., Somsák, L.: van der Waals interactions govern C-[beta]-D-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.
J. Struct. Biol. 199 (1), 57-67, 2017.

Kantsadi, A., Bokor, É., Kun, S., Stravodimos, G., Chatzileontiadou, D., Leonidas, D., Juhász-Tóth, É., Szakács, A., Batta, G., Docsa, T., Gergely, P., Somsák, L.: Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Eur. J. Med. Chem. 123 737-745, 2016.

Bokor, É., Kun, S., Docsa, T., Gergely, P., Somsák, L.: 4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS Med. Chem. Lett. 6 1215-1219, 2015.

Misra, A., Bokor, É., Kun, S., Bolyog-Nagy, E., Kathó, Á., Joó, F., Somsák, L.: Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media.
Tetrahedron Lett. 56 (44), 5995-5998, 2015.

Kun, S., Bokor, É., Varga, G., Szőcs, B., Páhi, A., Czifrák, K., Tóth, M., Juhász, L., Docsa, T., Gergely, P., Somsák, L.: New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4- triazoles, nanomolar inhibitors of glycogen phosphorylase.
Eur. J. Med. Chem. 76 567-579, 2014.

Somsák, L., Bokor, É., Czibere, B., Czifrák, K., Koppány, C., Kulcsár, L., Kun, S., Szilágyi, E., Tóth, M., Docsa, T., Gergely, P.: Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase.
Carbohydr. Res. 399 38-48, 2014.

Tóth, M., Kun, S., Somsák, L., Goyard, D.: Preparation of exo-Glycals from 2,6-Anhydro-aldose-tosylhydrazones.
In: Carbohydrate Chemistry : Proven Synthetic Methods Vol. 1.. Ed.: Pavol Kováč, CRC Press, Boca Raton, 367-375, 2012. ISBN: 9781439866894

Kun, S., Nagy, G., Tóth, M., Czecze, L., Van Nhien, A., Docsa, T., Gergely, P., Charavgi, M., Skourti, P., Chrysina, E., Patonay, T., Somsák, L.: Synthesis of variously coupled conjugates of d-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase.
Carbohydr. Res. 346 (12), 1427-1438, 2011.

Somsák, L., Bokor, É., Czifrák, K., Kónya, B., Kun, S., Tóth, M.: A glikogén foszforiláz glükózanalóg gátlószerei, mint potenciális antidiabetikumok.
Magy. Kém. F. 116 (1), 19-30, 2010.

Tóth, M., Kun, S., Bokor, É., Benltifa, M., Tallec, G., Vidal, S., Docsa, T., Gergely, P., Somsák, L., Praly, J.: Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorg. Med. Chem. 17 (13), 4773-4785, 2009.