Tudóstér: Czimmerer Zsolt publikációi

Kolostyák, Z., Bojcsuk, D., Baksa, V., Máthéné Szigeti, Z., Bene, K., Czimmerer, Z., Botó, P., Fadel, L., Póliska, S., Halász, L., Tzerpos, P., Berger, W., Villabona-Rueda, A., Varga, Z., Kovács, T., Patsalos, A., Pap, A., Vámosi, G., Bai, P., Dezső, B., Spite, M., D'Alessio,, F., Szatmári, I., Nagy, L.: EGR2 is an epigenomic regulator of phagocytosis and antifungal immunity in alveolar macrophages.
JCI Insight. 9 (17), 1-21, 2024.

Dániel, B., Belk, J., Meier, S., Chen, A., Sándor, K., Czimmerer, Z., Varga, Z., Bene, K., Buquicchio, F., Qi, Y., Kitano, H., Wheeler, J., Foster, D., Januszyk, M., Longaker, M., Chang, H., Satpathy, A.: Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state.
Mol. Cell. 83 (1), 121-138, 2023.

Domokos, A., Varga, Z., Jambrovics, K., Caballero-Sánchez, N., Szabó, E., Nagy, G., Scholtz, B., Halász, L., Váradi, E., Bene, K., Türk-Mázló, A., Bácsi, A., Jeney, V., Szebeni, G., Nagy, L., Czimmerer, Z.: The transcriptional control of the VEGFA-VEGFR1 (FLT1) axis in alternatively polarized murine and human macrophages.
Front. Immunol. 14 1-20, 2023.

Jambrovics, K., Botó, P., Pap, A., Sarang, Z., Kolostyák, Z., Czimmerer, Z., Szatmári, I., Fésüs, L., Uray, I., Balajthy, Z.: Transglutaminase 2 associated with PI3K and PTEN in a membrane-bound signalosome platform blunts cell death.
Cell Death Dis. 14 (3), 1-10, 2023.

Szénási, T., Varga, A., Hajas, G., Tóth, M., Czimmerer, Z., Bácsi, A.: "Trained" immunitás: memória kialakulása a veleszületett immunválaszok során.
Immunol. Szle. 14 (1), 15-21, 2022.

Szénási, T., Varga, A., Tóth, M., Hajas, G., Muzsai, S., Czimmerer, Z., Bácsi, A.: A BCG-oltás és a koronavírus-fertőzés immunológiai kapcsolata.
Immunol. Szle. 14 (1), 23-29, 2022.

Kupai, K., Várkonyi, T., Török, S., Gáti, V., Czimmerer, Z., Puskás, L., Szebeni, G.: Recent Progress in the Diagnosis and Management of Type 2 Diabetes Mellitus in the Era of COVID-19 and Single Cell Multi-Omics Technologies.
Life (Basel). 12 (8), 1-23, 2022.

Czimmerer, Z., Halász, L., Dániel, B., Varga, Z., Bene, K., Domokos, A., Hoeksema, M., Shen, Z., Berger, W., Silye-Cseh, T., Jambrovics, K., Kolostyák, Z., Fenyvesi, F., Váradi, J., Póliska, S., Hajas, G., Szatmári, I., Glass, C., Bácsi, A., Nagy, L.: The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands.
Immunity. 55 (11), 2006-2026, 2022.

Tóth, M., Muzsai, S., Regulski, K., Szendi-Szatmári, T., Czimmerer, Z., Rajnavölgyi, É., Chapot-Chartier, M., Bácsi, A.: The phagocytosis of Lacticaseibacillus casei and its immuno- modulatory properties on human monocyte-derived dendritic cells depend on the expression of Lc-p75, a bacterial peptidogly- can-hydrolase.
Int. J. Mol. Sci. 23 (14), 1-19, 2022.

Kovács, E., Alatshan, A., Budai, M., Czimmerer, Z., Bíró, E., Benkő, S.: Caffeine Has Different Immunomodulatory Effect on the Cytokine Expression and NLRP3 Inflammasome Function in Various Human Macrophage Subpopulations.
Nutrients. 13 (7), 2409, 2021.

Ivanovics, B., Gazsi, G., Reining, M., Berta, I., Póliska, S., Tóth, M., Domokos, A., Nagy, B., Staszny, Á., Cserháti, M., Csősz, É., Bácsi, A., Csenki-Bakos, Z., Ács, A., Urbányi, B., Czimmerer, Z.: Embryonic exposure to low concentrations of aflatoxin B1 triggers global transcriptomic changes, defective yolk lipid mobilization, abnormal gastrointestinal tract development and inflammation in zebrafish.
J. Hazard. Mater. 416 1-15, 2021.

Gazsi, G., Czimmerer, Z., Ivanovics, B., Berta, I., Urbányi, B., Csenki-Bakos, Z., Ács, A.: Physiological, Developmental, and Biomarker Responses of Zebrafish Embryos to Sub-Lethal Exposure of Bendiocarb.
Water. 13 (2), 2021.

Alatshan, A., Kovács, G., Aladdin, A., Czimmerer, Z., Tar, K., Benkő, S.: All-Trans Retinoic Acid Enhances both the Signaling for Priming and the Glycolysis for Activation of NLRP3 Inflammasome in Human Macrophage.
Cells. 9 (7), 1591, 2020.

Szilágyi, B., Fejes, Z., Póliska, S., Pócsi, M., Czimmerer, Z., Patsalos, A., Fenyvesi, F., Rusznyák, Á., Nagy, G., Kerekes, G., Berhés, M., Szűcs, I., Kunapuli, S., Kappelmayer, J., Nagy, B.: Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis.
Int. J. Mol. Sci. 21 (3), 1-22, 2020.

Dániel, B., Czimmerer, Z., Halász, L., Botó, P., Kolostyák, Z., Póliska, S., Berger, W., Tzerpos, P., Nagy, G., Horváth, A., Hajas, G., Silye-Cseh, T., Nagy, A., Sauer, S., Francois-Deleuze, J., Szatmári, I., Bácsi, A., Nagy, L.: The transcription factor EGR2 is the molecular linchpin connecting STAT6 activation to the late, stable epigenomic program of alternative macrophage polarization.
Genes Dev. 34 (21-22), 1474-1492, 2020.

Czimmerer, Z., Halász, L., Nagy, L.: Unorthodox Transcriptional Mechanisms of Lipid-Sensing Nuclear Receptors in Macrophages: are We Opening a New Chapter?.
Front Endocrinol (Lausanne). 11 1-13, 2020.

Horváth, A., Dániel, B., Széles, L., Cuaranta-Monroy, I., Czimmerer, Z., Ozgyin, L., Steiner, L., Kiss, M., Simándi, Z., Póliska, S., Giannakis, N., Raineri, E., Gut, I., Nagy, B., Nagy, L.: Labelled regulatory elements are pervasive features of the macrophage genome and are dynamically utilized by classical and alternative polarization signals.
Nucleic Acids Res. 47 (6), 2778-2792, 2019.

Czimmerer, Z., Horváth, A., Dániel, B., Nagy, G., Cuaranta-Monroy, I., Kiss, M., Kolostyák, Z., Póliska, S., Steiner, L., Giannakis, N., Varga, T., Nagy, L.: Dynamic transcriptional control of macrophage miRNA signature via inflammation responsive enhancers revealed using a combination of next generation sequencing-based approaches.
Biochim. Biophys. Acta. Gene Regul. Mech. 1861 (1), 14-28, 2018.

Fejes, Z., Czimmerer, Z., Szűk, T., Póliska, S., Horváth, A., Balogh, E., Jeney, V., Váradi, J., Fenyvesi, F., Balla, G., Édes, I., Balla, J., Kappelmayer, J., Nagy, B.: Endothelial cell activation is attenuated by everolimus via transcriptional and post-transcriptional regulatory mechanisms after drug-eluting coronary stenting.
PLoS One. 13 (6), 1-20, 2018.

Czimmerer, Z., Nagy, Z., Nagy, G., Horváth, A., Silye-Cseh, T., Kriston, Á., Jonás, D., Sauer, S., Steiner, L., Dániel, B., Deleuze, J., Nagy, L.: Extensive and functional overlap of the STAT6 and RXR cistromes in the active enhancer repertoire of human CD14+ monocyte derived differentiating macrophages.
Mol. Cell. Endocrinol. 471 63-74, 2018.

Beceiro, S., Pap, A., Czimmerer, Z., Sallam, T., Guillén, J., Gallardo, G., Hong, C., A-Gonzalez, N., Tabraue, C., Diaz, M., Lopez, F., Matalonga, J., Valledor, A., Dominguez, P., Ardavin, C., Delgado-Martin, C., Partida-Sanchez, S., Rodriguez-Fernandez, J., Nagy, L., Tontonoz, P., Castrillo, A.: Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis.
Mol. Cell. Biol. 38 (10), 1-18, 2018.

Dániel, B., Nagy, G., Horváth, A., Czimmerer, Z., Cuaranta-Monroy, I., Póliska, S., Hays, T., Sauer, S., Francois-Deleuze, J., Nagy, L.: The IL-4/STAT6/PPAR[gamma] signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.
Nucleic Acids Res. 46 (9), 4425-4439, 2018.

Dániel, B., Nagy, G., Czimmerer, Z., Horváth, A., Hammers, D., Cuaranta-Monroy, I., Póliska, S., Tzerpos, P., Kolostyák, Z., Hays, T., Patsalos, A., Houtman, R., Sauer, S., Francois-Deleuze, J., Rastinejad, F., Bálint, B., Sweeney, H., Nagy, L.: The Nuclear Receptor PPAR[gamma] Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.
Immunity. 49 (4), 615-626, 2018.

Czimmerer, Z., Dániel, B., Horváth, A., Rückerl, D., Nagy, G., Kiss, M., Peloquin, M., Budai, M., Cuaranta-Monroy, I., Simándi, Z., Steiner, L., Nagy, B., Póliska, S., Bankó, C., Bacsó, Z., Schulman, I., Sauer, S., Deleuze, J., Allen, J., Benkő, S., Nagy, L.: The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.
Immunity. 48 (1), 75-90, 2018.

Fejes, Z., Póliska, S., Czimmerer, Z., Káplár, M., Penyige, A., Gál Szabó, G., Bekéné Debreceni, I., Kunapuli, S., Kappelmayer, J., Nagy, B.: Hyperglycemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus.
Thromb. Haemost. 117 (3), 529-542, 2017.

Kiss, M., Czimmerer, Z., Nagy, G., Bieniasz-Krzywiec, P., Ehling, M., Pap, A., Póliska, S., Botó, P., Tzerpos, P., Horváth, A., Kolostyák, Z., Dániel, B., Szatmári, I., Mazzone, M., Nagy, L.: Retinoid X receptor suppresses a metastasis-promoting transcriptional program in myeloid cells via a ligand-insensitive mechanism.
Proc. Natl. Acad. Sci. U. S. A. 114 (40), 10725-10730, 2017.

Czimmerer, Z., Varga, T., Kiss, M., Vázquez, C., Doan-Xuan, Q., Rückerl, D., Tattikota, S., Yan, X., Nagy, Z., Dániel, B., Póliska, S., Horváth, A., Nagy, G., Varallyay, É., Poy, M., Allen, J., Bacsó, Z., Abreu-Goodger, C., Nagy, L.: The IL-4/STAT6 signaling axis establishes a conserved microRNA signature in human and mouse macrophages regulating cell survival via miR-342-3p.
Genome Med. 8 (1), 1-22, 2016.

Gyöngyösi, A., Dócs, O., Czimmerer, Z., Orosz, L., Horváth, A., Török, O., Méhes, G., Nagy, L., Bálint, B.: Measuring expression levels of small regulatory RNA molecules from body fluids and formalin-fixed, paraffin-embedded samples.
In: RNA Mapping : Methods and Protocols . Ed.: M. Lucrecia Alvarez, Mahtab Nourbakhsh, Humana Press, New York, 105-119, 2014. ISBN: 9781493910618(Print)9781493910625(Online)

Dániel, B., Nagy, G., Hah, N., Horváth, A., Czimmerer, Z., Póliska, S., Gyuris, T., Keirsse, J., Gysemans, C., Van Ginderachter, J., Bálint, B., Evans, R., Barta, E., Nagy, L.: The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.
Genes Dev. 28 (14), 1562-1577, 2014.

Czimmerer, Z., Hulvely, J., Simándi, Z., Varallyay, É., Havelda, Z., Szabó, E., Varga, A., Dezső, B., Balogh, M., Horváth, A., Domokos, B., Török, Z., Nagy, L., Bálint, B.: A versatile method to design stem-loop primer-based quantitative PCR assays for detecting small regulatory RNA molecules.
PLoS One. 8 (1), 1-10, 2013.

Nagy, Z., Czimmerer, Z., Nagy, L.: Nuclear receptor mediated mechanisms of macrophage cholesterol metabolism.
Mol. Cell. Endocrinol. 368 (1-2), 85-98, 2013.

Nagy, Z., Czimmerer, Z., Szántó, A., Nagy, L.: Pro-inflammatory cytokines negatively regulate PPARγ mediated gene expression in both human and murine macrophages via multiple mechanisms.
Immunobiology. 218 (11), 1336-1344, 2013.

Brignull, L., Czimmerer, Z., Saidi, H., Dániel, B., Villela, I., Bartlett, N., Johnston, S., Meira, L., Nagy, L., Nohturfft, A.: Reprogramming of lysosomal gene expression by interleukin-4 and Stat6.
BMC Genomics. 14 (1), 1-20, 2013.

Kiss, M., Czimmerer, Z., Nagy, L.: The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: from physiology to pathology.
J. Allergy Clin. Immunol. 132 (2), 264-286, 2013.

Czimmerer, Z., Varga, T., Póliska, S., Német, I., Szántó, A., Nagy, L.: Identification of novel markers of alternative activation and potential endogenous PPARgamma ligand production mechanisms in human IL-4 stimulated differentiating macrophages.
Immunobiology. 217 (12), 1301-1314, 2012.

Mikó, E., Margitai, Z., Czimmerer, Z., Várkonyi, I., Dezső, B., Lányi, Á., Bacsó, Z., Scholtz, B.: miR-126 inhibits proliferation of small cell lung cancer cells by targeting SLC7A5.
FEBS Lett. 585 (8), 1191-1196, 2011.

Varga, T., Czimmerer, Z., Nagy, L.: PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Biochim. Biophys. Acta. Mol. Basis Dis. 1812 (8), 1007-1022, 2011.

Oberoi, J., Fairall, L., Watson, P., Yang, J., Czimmerer, Z., Kampmann, T., Goult, B., Greenwood, J., Gooch, J., Kallenberger, B., Nagy, L., Neuhaus, D., Schwabe, J.: Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery.
Nat. Struct. Mol. Biol. 18 (2), 177-184, 2011.

Mikó, E., Czimmerer, Z., Csánky, E., Boros, G., Buslig, J., Dezső, B., Scholtz, B.: Differentially expressed microRNAs in small cell lung cancer.
Exp. Lung Res. 35 (8), 646-664, 2009.

Röszer, T., Jenei, Z., Gáll, T., Nagy, O., Czimmerer, Z., Serfőző, Z., Elekes, K., Bánfalvi, G.: A possible stimulatory effect of FMRFamide on neural nitric oxide production in the central nervous system of Helix lucorum L..
Brain. Behav. Evol. 63 (1), 23-33, 2004.

Röszer, T., Czimmerer, Z., Szentmiklósi, J., Bánfalvi, G.: Nitric oxide synthesis is blocked in the enteral nervous system during dormant periods of the snail Helix lucorum L..
Cell Tissue Res. 316 255-262, 2004.

Röszer, T., Jenei, Z., Serfőző, Z., Czimmerer, Z., Bánfalvi, G.: Structural diversity of NADPH diaphorase-reactive enteral networks in Stylommatophora (Gastropoda, Pulmonata).
Invertebr. Biol. 123 (2), 128-135, 2004.