Tudóstér: Bokor Éva publikációi

Bokor, É., Kecskés, D., Gombás, F., Fehér, A., Kardos, E., Dabian, A., Vonza, Z., Szennyes, E., Somsák, L.: First representatives of C-glycosyl 1,2,4,5-tetrazines: synthesis of 3-beta-d-glucopyranosyl 1,2,4,5-tetrazines and their transformation into 3-beta-d-glucopyranosyl pyridazines.
New Journal of Chemistry 47 (1), 56-74, 2023.

Kacsir, I., Sipos, A., Kiss, T., Major, E., Bajusz, N., Tóth, E., Buglyó, P., Somsák, L., Kardos, G., Bai, P., Bokor, É.: Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria.
Front. Chem. 11 1-18, 2023.

Kacsir, I., Sipos, A., Major, E., Bajusz, N., Bényei, A., Buglyó, P., Somsák, L., Kardos, G., Bai, P., Bokor, É.: Half-sandwich type platinum-group metal complexes of C-Glucosaminyl azines: syntheses, antineoplastic and antimicrobial activities.
Molecules. 28 (7), 1-55, 2023.

Bokor, É., Ferenczi, A., Hashimov, M., Juhász-Tóth, É., Götz, Z., Zaki, A., Somsák, L.: First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions There of.
Molecules. 27 (22), 1-16, 2022.

Kacsir, I., Sipos, A., Bényei, A., Janka, E., Buglyó, P., Somsák, L., Bai, P., Bokor, É.: Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.
Int. J. Mol. Sci. 23 (2), 1-39, 2022.

Balázs, B., Tóth, Z., Kacsir, I., Sipos, A., Buglyó, P., Somsák, L., Bokor, É., Kardos, G., Bai, P.: Targeting multiresistant Gram-positive bacteria by ruthenium, osmium, iridium and rhodium half-sandwich type complexes with bidentate monosaccharide ligands.
Front. Chem. 10 1-9, 2022.

Sipos, Á., Szennyes, E., Hajnal, É., Kun, S., Szabó, E., Uray, K., Somsák, L., Docsa, T., Bokor, É.: Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.
Pharmaceuticals. 14 (4), 1-27, 2021.

Kacsir, I., Sipos, A., Ujlaki, G., Buglyó, P., Somsák, L., Bai, P., Bokor, É.: Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species production.
Int. J. Mol. Sci. 221 1-41, 2021.

Bokor, É.: N- and C-Glycopyranosyl heterocycles as glycogen phosphorylase inhibitors.
In: Recent Trends in Carbohydrate Chemistry. Ed.: by Amélia Pilar Rauter, Bjørn E. Christensen, László Somsák, Paul Kosma, Roberto Adamo, Elsevier Inc., Amsterdam, 253-300, 2020. ISBN: 9780128174678

Szennyes, E., Gyémánt, G., Somsák, L., Bokor, É.: Synthesis of New Series of 2-C-(béta-D-glucopyranosyl)-Pyrimidines and Their Evaluation as Inhibitors of Some Glycoenzymes.
Molecules. 25 (3), 1-18, 2020.

Kyriakis, E., Karra, A., Papaioannou, O., Solovou, T., Skamnaki, V., Liggri, P., Zographos, S., Szennyes, E., Bokor, É., Kun, S., Psarra, A., Somsák, L., Leonidas, D.: The architecture of hydrogen and sulfur α-hole interactions explain differences in the inhibitory potency of C-β-d-glucopyranosyl thiazoles, imidazoles and an N-β-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design.
Bioorg. Med. Chem. 28 (1), 1-10, 2020.

Barr, D., Szennyes, E., Bokor, É., Al-Oanzi, Z., Moffatt, C., Kun, S., Docsa, T., Sipos, Á., Davies, M., Mathomes, R., Snape, T., Agius, L., Somsák, L., Hayes, J.: Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies.
ACS Chem. Biol. 14 (7), 1460-1470, 2019.

Somsák, L., Bokor, É., Juhász, L., Kun, S., Lázár, L., Juhász-Tóth, É., Tóth, M.: New syntheses towards C-glycosyl type glycomimetics.
Pure Appl. Chem. 91 (7), 1159-1175, 2019.

Szennyes, E., Bokor, É., Docsa, T., Sipos, Á., Somsák, L.: Synthesis of C-β-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase.
Carbohydr. Res. 472 33-41, 2019.

Kun, S., Begum, J., Kyriakis, E., Stamati, E., Barkas, T., Szennyes, E., Bokor, É., Szabó, E., Stravodimos, G., Sipos, Á., Docsa, T., Gergely, P., Moffatt, C., Patraskaki, M., Kokolaki, M., Gkerdi, A., Skamnaki, V., Leonidas, D., Somsák, L., Hayes, J.: A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors.
Eur. J. Med. Chem. 147 266-278, 2018.

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L., Bai, P.: Glycogen phosphorylase inhibition improves beta cell function.
Br. J. Pharmacol. 175 (2), 301-319, 2018.

Kyriakis, E., Solovou, T., Kun, S., Czifrák, K., Szőcs, B., Juhász, L., Bokor, É., Stravodimos, G., Kantsadi, A., Chatzileontiadou, D., Skamnaki, V., Somsák, L., Leonidas, D.: Probing the [beta]-pocket of the active site of human liver glycogen phosphorylase with 3-(C-[beta]-D-glucopyranosyl)-5-(4-substituted-phenyl)-1, 2, 4-triazole inhibitors.
Bioorganic Chem. 77 485-493, 2018.

Kun, S., Bokor, É., Sipos, Á., Docsa, T., Somsák, L.: Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.
Molecules. 23 (3), 1-17, 2018.

Szennyes, E., Bokor, É., Langer, P., Gyémánt, G., Docsa, T., Sipos, Á., Somsák, L.: The first general synthesis of 2-C-(beta-D-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes.
New J. Chem. 42 (21), 17439-17446, 2018.

Bokor, É., Kun, S., Goyard, D., Tóth, M., Praly, J., Vidal, S., Somsák, L.: C-Glycopyranosyl Arenes and Hetarenes: Synthetic Methods and Bioactivity Focused on Antidiabetic Potential.
Chem. Rev. 117 (3), 1687-1764, 2017.

Bokor, É., Kyriakis, E., Solovou, T., Koppány, C., Kantsadi, A., Szabó, E., Szakács, A., Stravodimos, G., Docsa, T., Skamnaki, V., Zographos, S., Gergely, P., Leonidas, D., Somsák, L.: Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
J. Med. Chem. 60 (22), 9251-9262, 2017.

Szennyes, E., Bokor, É., Kiss-Szikszai, A., Somsák, L., Pascal, Y.: Preparation of 2,6-anhydro-3,4,5,7-tetra-O-benzyl-D-glycero-D-gulo-heptonimidamide.
In: Carbohydrate Chemistry: Proven Synthetic Methods / Christian Vogel, Paul Murphy, CRC Press-Taylor & Francis Group, Boca Raton, 323-332, 2017, (Volume 4 ) ISBN: 9781498726917

Agócs, A., Bokor, É., Takátsy, A., Lóránd, T., Deli, J., Somsák, L., Nagy, V.: Synthesis of carotenoid-monosaccharide conjugates via azide-alkyne click-reaction.
Tetrahedron. 73 (5), 519-526, 2017.

Kantsadi, A., Stravodimos, G., Kyriakis, E., Chatzileontiadou, D., Solovou, T., Kun, S., Bokor, É., Somsák, L.: van der Waals interactions govern C-[beta]-D-glucopyranosyl triazoles' nM inhibitory potency in human liver glycogen phosphorylase.
J. Struct. Biol. 199 (1), 57-67, 2017.

Bokor, É., Széles, Z., Docsa, T., Gergely, P., Somsák, L.: C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase.
Carbohydr. Res. 429 128-134, 2016.

Szennyes, E., Bokor, É., Batta, G., Docsa, T., Gergely, P., Somsák, L.: Improved preparation of 4(5)-aryl-2-(β-D-glucopyranosyl)-imidazoles, the most efficient glucose analogue inhibitors of glycogen phosphorylase.
RSC Adv. 6 (97), 94787-94794, 2016.

Kantsadi, A., Bokor, É., Kun, S., Stravodimos, G., Chatzileontiadou, D., Leonidas, D., Juhász-Tóth, É., Szakács, A., Batta, G., Docsa, T., Gergely, P., Somsák, L.: Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase.
Eur. J. Med. Chem. 123 737-745, 2016.

Bokor, É., Kun, S., Docsa, T., Gergely, P., Somsák, L.: 4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase.
ACS Med. Chem. Lett. 6 1215-1219, 2015.

Bokor, É.: Antidiabetikus cukorszármazékok (Antidiabetic sugar derivatives).
Magy. Kém. F. 121 (1), 4-12, 2015.

Bokor, É., Szennyes, E., Csupász, T., Tóth, N., Docsa, T., Gergely, P., Somsák, L.: C-(2-Deoxy-D-arabino-hex-1-enopyranosyl)-oxadiazoles: synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors.
Carbohydr. Res. 412 71-79, 2015.

Misra, A., Bokor, É., Kun, S., Bolyog-Nagy, E., Kathó, Á., Joó, F., Somsák, L.: Chemoselective hydration of glycosyl cyanides to C-glycosyl formamides using ruthenium complexes in aqueous media.
Tetrahedron Lett. 56 (44), 5995-5998, 2015.

Szőcs, B., Bokor, É., Szabó, E., Kiss-Szikszai, A., Tóth, M., Somsák, L.: Synthesis of 5-aryl-3-C-glycosyl- and unsymmetrical 3,5-diaryl-1,2,4-triazoles from alkylidene-amidrazones.
RSC Advances. 5 (54), 43620-43629, 2015.

Kun, S., Bokor, É., Varga, G., Szőcs, B., Páhi, A., Czifrák, K., Tóth, M., Juhász, L., Docsa, T., Gergely, P., Somsák, L.: New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4- triazoles, nanomolar inhibitors of glycogen phosphorylase.
Eur. J. Med. Chem. 76 567-579, 2014.

Somsák, L., Bokor, É., Czibere, B., Czifrák, K., Koppány, C., Kulcsár, L., Kun, S., Szilágyi, E., Tóth, M., Docsa, T., Gergely, P.: Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase.
Carbohydr. Res. 399 38-48, 2014.

Bokor, É., Fekete, A., Varga, G., Szőcs, B., Czifrák, K., Komáromi, I., Somsák, L.: C-(β-d-Glucopyranosyl)formamidrazones, formic acid hydrazides and their transformations into 3-(β-d-glucopyranosyl)-5-substituted-1,2,4-triazoles: a synthetic and computational study.
Tetrahedron. 69 (48), 10391-10404, 2013.

Bokor, É., Docsa, T., Gergely, P., Somsák, L.: C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase.
ACS Med. Chem. Lett. 4 (7), 612-615, 2013.

Bokor, É., Szilágyi, E., Docsa, T., Gergely, P., Somsák, L.: Synthesis of substituted 2-(β-d-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.
Carbohydr. Res. 381C 179-186, 2013.

Bokor, É., Koppány, C., Gonda, Z., Novák, Z., Somsák, L.: Evaluation of bis-triphenylphosphano-copper(I)-butyrate (C3H7COOCu(PPh3)2) as catalyst for the synthesis of 1-glycopyranosyl-4-substituted-1,2,3-triazoles.
Carbohydr. Res. 351 42-48, 2012.

Somsák, L., Bokor, É., Czifrák, K., Juhász, L., Tóth, M.: Carbohydrate Derivatives and Glycomimetic Compounds in Established and Investigational Therapies of Type 2 Diabetes Mellitus.
In: Topics in the Prevention, Treatment and Complications of Type 2 Diabetes. Ed.: Marc B. Zimering, InTech Open Access Publisher, Rijeka, 103-126, 2011.

Somsák, L., Bokor, É., Czifrák, K., Juhász, L., Tóth, M.: Carbohydrate derivatives and glycomimetic compounds in established and investigational therapies of type 2 diabetes mellitus.
In: Topics in the Prevention, Treatment and Complications of Type 2 Diabetes / Mark B. Zimering, InTech, Rijeka, 103-126, 2011. ISBN: 9789533075907

Somsák, L., Bokor, É., Czifrák, K., Kónya, B., Kun, S., Tóth, M.: A glikogén foszforiláz glükózanalóg gátlószerei, mint potenciális antidiabetikumok.
Magy. Kém. F. 116 (1), 19-30, 2010.

Bokor, É.: Heterociklusos glükózszármazékok, mint lehetséges antidiabetikumok (Heterocyclic glucose derivatives as potential antidiabetics).
Magy. Kém. Lapja. 65 (3), 77-78, 2010.

Bokor, É., Docsa, T., Gergely, P., Somsák, L.: Synthesis of 1-(D-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors.
Bioorg. Med. Chem. 18 (3), 1171-1180, 2010.

Cheng, K., Liu, J., Sun, H., Bokor, É., Czifrák, K., Kónya, B., Tóth, M., Docsa, T., Gergely, P., Somsák, L.: Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase.
New J. Chem. 34 1450-1464, 2010.

Chrysina, E., Bokor, É., Alexacou, K., Charavgi, M., Oikonomakos, G., Zographos, S., Leonidas, D., Oikonomakos, N., Somsák, L.: Amide-1,2,3-triazole bioisosterism: the glycogen phosphorylase case.
Tetrahedron Asymmetry. 20 (6-8), 733-740, 2009.

Tóth, M., Kun, S., Bokor, É., Benltifa, M., Tallec, G., Vidal, S., Docsa, T., Gergely, P., Somsák, L., Praly, J.: Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase.
Bioorg. Med. Chem. 17 (13), 4773-4785, 2009.

Somsák, L., Hüse, C., Felföldi, N., Kónya, B., Telepó, K., Bokor, É., Czifrák, K.: Assessment of synthetic methods for the preparation of N-beta-D-glucopyranosyl-N'-substituted ureas, -thioureas and related compounds.
Carbohydr. Res. 343 (12), 2083-2093, 2008.

Somsák, L., Czifrák, K., Tóth, M., Bokor, É., Chrysina, E., Alexacou, K., Hayes, J., Tiraidis, C., Lazoura, E., Leonidas, D., Zographos, S., Oikonomakos, G.: New inhibitors of glycogen phosphorylase as potential antidiabetic agents.
Curr. Med. Chem. 15 (28), 2933-2983, 2008.