Tudóstér: MTA-DE Lendület Sejtmetabolizmus Kutatócsoport publikációi

Kacsir, I., Sipos, A., Kiss, T., Major, E., Bajusz, N., Tóth, E., Buglyó, P., Somsák, L., Kardos, G., Bai, P., Bokor, É.: Half sandwich-type osmium, ruthenium, iridium and rhodium complexes with bidentate glycosyl heterocyclic ligands induce cytostasis in platinum-resistant ovarian cancer cells and bacteriostasis in Gram-positive multiresistant bacteria.
Front. Chem. 11 1-18, 2023.

Kacsir, I., Sipos, A., Major, E., Bajusz, N., Bényei, A., Buglyó, P., Somsák, L., Kardos, G., Bai, P., Bokor, É.: Half-sandwich type platinum-group metal complexes of C-Glucosaminyl azines: syntheses, antineoplastic and antimicrobial activities.
Molecules. 28 (7), 1-55, 2023.

Ujlaki, G., Kovács, T., Vida, A., Kókai, E., Rauch, B., Schwarcz, S., Mikó, E., Janka, E., Sipos, A., Hegedűs, C., Uray, K., Nagy, P., Bai, P.: Identification of bacterial metabolites modulating breast cancer cell proliferation and epithelial-mesenchymal transition.
Molecules. 28 (15), 1-18, 2023.

Antal, D., Pór, Á., Kovács, I., Dull, K., Póliska, S., Ujlaki, G., Demény, M., Szöllősi, A., Kiss, B., Szegedi, A., Bai, P., Szántó, M.: PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes.
J. Mol. Med. (Berl). 101 (8), 987-999, 2023.

Antal, D., Pór, Á., Kovács, I., Dull, K., Póliska, S., Ujlaki, G., Demény, M., Szöllősi, A., Kiss, B., Szegedi, A., Bai, P., Szántó, M.: PARP2 promotes inflammation in sporiasis by modulating estradiol biosynthesis in keratinocytes.
In: FEBS Advanced Lecture Course: PARP 2023: Research on the family of poly(ADP-ribose) polymerases; Book of Abstracts. Ed.: Andreja Mikoc, Ivan Matic, Ruder Boskovic Institue, Hvar, 60, 2023. ISBN: 9789537941468

Schwarcz, S., Kovács, P., Kovács, T., Ujlaki, G., Nyerges, P., Uray, K., Bai, P., Mikó, E.: The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models.
Mol. Biol. Rep. 50 (6), 5273-5282, 2023.

Bai, P.: Az onkobiózis és a daganatok kapcsolata.
Orvostovábbk. szle. 29 (8), 79-83, 2022.

Antal, D., Janka, E., Szabó, J., Szabó, I., Szegedi, A., Gáspár, K., Bai, P., Szántó, M.: Culture-based analyses of skin bacteria in lesional moist, and unaffected dry and sebaceous skin regions of hidradenitis suppurativa patients.
J. Eur. Acad. Dermatol. Venereol. 36 (9), e731-e733, 2022.

Nagy, L., Rauch, B., Szerafin, T., Uray, K., Tóth, A., Bai, P.: Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production.
Front. Cell. Dev. Biol. 10 1-12, 2022.

Wang, L., Wang, D., Sonzogni, O., Ke, S., Wang, Q., Thavamani, A., Batalini, F., Stopka, S., Regan, M., Vandal, S., Tian, S., Pinto, J., Cyr, A., Bret-Mounet, V., Baquer, G., Eikesdal, H., Yuan, M., Asara, J., Heng, Y., Bai, P., Agar, N., Wulf, G.: PARP-inhibition reprograms macrophages toward an anti-tumor phenotype.
Cell Reports. 41 (2), 1-22, 2022.

Antal, D., Pór, Á., Dull, K., Kovács, I., Szegedi, A., Bai, P., Szántó, M.: Poly(ADP-ribose) polymerase (PARP)-2 promotes inflammation in psoriasis by regulating estradiol biosynthesis in keratinocytes.
J. Invest. Dermatol. 142 (12), S237, 2022.

Kacsir, I., Sipos, A., Bényei, A., Janka, E., Buglyó, P., Somsák, L., Bai, P., Bokor, É.: Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.
Int. J. Mol. Sci. 23 (2), 1-39, 2022.

Režen, T., Rozman, D., Kovács, T., Kovács, P., Sipos, A., Bai, P., Mikó, E.: The role of bile acids in carcinogenesis.
Cell. Mol. Life Sci. 79 (5), 1-39, 2022.

Mikó, E., Bai, P.: A mikrobiom és a rák.
Klin. Onkol. 8 (4), 313-319, 2021.

Hegedűs, C., Juhász, T., Fidrus, E., Janka, E., Juhász, G., Boros, G., Paragh, G., Uray, K., Emri, G., Remenyik, É., Bai, P.: Cyclobutane pyrimidine dimers from UVB exposure induce a hypermetabolic state in keratinocytes via mitochondrial oxidative stress.
Redox Biol. 38 1-17, 2021.

Smolková, K., Bai, P.: Editorial: Epithelial-Mesenchymal Transition : Yet Another Exciting Avenue in Cancer Metabolic Remodeling.
Front Oncol. 10 1-3, 2021.

Kis, A., Dénes, N., Péli-Szabó, J., Arató, V., Beke, L., Matolay, O., Enyedi, K., Méhes, G., Mező, G., Bai, P., Kertész, I., Trencsényi, G.: In Vivo Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using 68Ga-NODAGA-c(NGR) Peptide.
BioMed Res. Inter. 2021 1-11, 2021.

Kiss, B., Mikó, E., Sebő, É., Tóth, J., Ujlaki, G., Szabó, J., Uray, K., Bai, P., Árkosy, P.: Onkobiózis és mikrobiális metabolikus jelátvitel pancreas-adenocarcinomában.
Cent. Eur. J. Gastro. Hepatol. 7 (2), 57-65, 2021.

Szántó, M., Gupte, R., Kraus, W., Pacher, P., Bai, P.: PARPs in lipid metabolism and related diseases.
Prog. Lipid Res. 84 1-24, 2021.

Kovács, T., Mikó, E., Ujlaki, G., Mustafa, H., Csontos, V., Uray, K., Bai, P.: The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer.
Cancer Metastasis Rev. 40 1223-1249, 2021.

Sipos, A., Ujlaki, G., Mikó, E., Maka, E., Szabó, J., Uray, K., Krasznai, Z., Bai, P.: The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling.
Mol. Med. 27 (1), 1-20, 2021.

Méhes, G., Matolay, O., Beke, L., Czenke, M., Pórszász, R., Mikó, E., Bai, P., Berényi, E., Trencsényi, G.: Carbonic Anhydrase Inhibitor Acetazolamide Enhances CHOP Treatment Response and Stimulates Effector T-Cell Infiltration in A20/BalbC Murine B-Cell Lymphoma.
Int. J. Mol. Sci. 21 (14), 1-14, 2020.

Sári, Z., Kovács, T., Csonka, T., Török, M., Sebő, É., Tóth, J., Tóth, D., Mikó, E., Kiss, B., Szeőcs, D., Uray, K., Karányi, Z., Kovács, I., Méhes, G., Árkosy, P., Bai, P.: Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma.
Physiol Int. 107 (2), 349-358, 2020.

Nagy, L., Béke, F., Juhász, L., Kovács, T., Juhász-Tóth, É., Docsa, T., Tóth, A., Gergely, P., Somsák, L., Bai, P.: Glycogen phosphorylase inhibitor, 2,3-bis[(2E)-3-(4-hydroxyphenyl)prop-2-enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells.
PLoS One. 15 (9), 1-15, 2020.

Sári, Z., Mikó, E., Kovács, T., Jankó, L., Csonka, T., Lente, G., Sebő, É., Tóth, J., Tóth, D., Árkosy, P., Boratkó, A., Ujlaki, G., Török, M., Kovács, I., Szabó, J., Kiss, B., Méhes, G., Goedert, J., Bai, P.: Indolepropionic Acid, a Metabolite of the Microbiome, Has Cytostatic Properties in Breast Cancer by Activating AHR and PXR Receptors and Inducing Oxidative Stress.
Cancers (Basel). 12 (9), 1-27, 2020.

Sári, Z., Mikó, E., Kovács, T., Boratkó, A., Ujlaki, G., Jankó, L., Kiss, B., Uray, K., Bai, P.: Indoxylsulfate, a Metabolite of the Microbiome, Has Cytostatic Effects in Breast Cancer via Activation of AHR and PXR Receptors and Induction of Oxidative Stress.
Cancers (Basel). 12 (10), 1-23, 2020.

Smolková, K., Mikó, E., Kovács, T., Leguina-Ruzzi, A., Sipos, A., Bai, P.: Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism.
Antioxid. Redox Signal. 33 (13), 966-997, 2020.

Kiss, B., Mikó, E., Sebő, É., Tóth, J., Ujlaki, G., Szabó, J., Uray, K., Bai, P., Árkosy, P.: Oncobiosis and microbial metabolite signaling in pancreatic adenocarcinoma.
Cancers (Basel). 12 (5), 1-34, 2020.

Hegedűs, C., Boros, G., Fidrus, E., Kis, G., Antal, M., Juhász, T., Janka, E., Jankó, L., Paragh, G., Emri, G., Bai, P., Remenyik, É.: PARP1 Inhibition Augments UVB-Mediated Mitochondrial Changes-Implications for UV-Induced DNA Repair and Photocarcinogenesis.
Cancers (Basel). 12 (1), 5, 2020.

Curtin, N., Bai, P.: PARPs, PAR and NAD metabolism and their inhibitors in cancer.
Cancers (Basel). 12 1-3, 2020.

Kiss, B., Szántó, M., Hegedűs, C., Antal, D., Szödényi, A., Márton, J., Méhes, G., Virág, L., Szegedi, A., Bai, P.: Poly(ADP-ribose) polymerase-1 depletion enhances the severity of inflammation in an imiquimod-induced model of psoriasis.
Exp. Dermatol. 29 (1), 79-85, 2020.

Lódi, M., Bánhegyi, V., Bódi, B., Gyöngyösi, A., Kovács, Á., Árokszállási, A., Hamdani, N., Fagyas, M., Édes, I., Csanádi, Z., Czuriga, I., Kisvárday, Z., Lekli, I., Bai, P., Tóth, A., Papp, Z., Czuriga, D.: Prophylactic, single-drug cardioprotection in a comparative, experimental study of doxorubicin-induced cardiomyopathy.
J. Transl. Med. 18 (1), 470, 2020.

Curtin, N., Bányai, K., Thaventhiran, J., Le, Q., Helyes, Z., Bai, P.: Repositioning PARP inhibitors for SARS-CoV-2 infection (COVID-19); a new multi-pronged therapy for ARDS?.
Br. J. Pharmacol. 177 (16), 3635-3645, 2020.

Jankó, L., Sári, Z., Kovács, T., Kis, G., Szántó, M., Antal, M., Juhász, A., Bai, P.: Silencing of PARP2 blocks autophagic degradation.
Cells. 9 (2), 1-21, 2020.

Vida, A., Bodrogi, B., Balogh, B., Bai, P.: Taxamat: automated biodiversity data management tool - implications for microbiome studies.
Physiol Int. 107 (1), 12-17, 2020.

Kovács, T., Mikó, E., Ujlaki, G., Sári, Z., Bai, P.: The Microbiome as a Component of the Tumor Microenvironment.
In: Tumor Microenvironment / Alexander Birbrair, Springer Nature - Springer Cham, Switzerland, 137-153, 2020, (dvances in Experimental Medicine and Biology, 0065-2598 ; 1225) ISBN: 9783030357269

Szabó, Z., Marosvölgyi, T., Szabó, É., Bai, P., Figler, M., Verzár, Z.: The Potential Beneficial Effect of EPA and DHA Supplementation Managing Cytokine Storm in Coronavirus Disease.
Front. Physiol. 11 1-5, 2020.

Szántó, M., Bai, P.: The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation and metabolism.
Genes Dev. 34 (5-6), 321-340, 2020.

Bánfai, K., Ernszt, D., Pap, A., Bai, P., Garai, K., Belharazem, D., Pongrácz, J., Kvell, K.: "Beige" cross talk between the immune system and metabolism.
Front Endocrinol (Lausanne). 10 369, 2019.

Lódi, M., Priksz, D., Fülöp, G., Bódi, B., Gyöngyösi, A., Nagy, L., Kovács, Á., Kertész, A., Kocsis, J., Édes, I., Csanádi, Z., Czuriga, I., Kisvárday, Z., Juhász, B., Lekli, I., Bai, P., Tóth, A., Papp, Z., Czuriga, D.: Advantages of prophylactic versus conventionally scheduled heart failure therapy in an experimental model of doxorubicin-induced cardiomyopathy.
J. Transl. Med. 17 229, 2019.

Kovács, T., Mikó, E., Vida, A., Sebő, É., Tóth, J., Csonka, T., Boratkó, A., Ujlaki, G., Lente, G., Kovács, P., Tóth, D., Árkosy, P., Kiss, B., Méhes, G., Goedert, J., Bai, P.: Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors.
Sci Rep. 9 (1), 1-14, 2019.

Kristóf, E., Klusóczki, Á., Veress, R., Shaw, A., Combi, Z., Varga, K., Győry, F., Balajthy, Z., Bai, P., Bacsó, Z., Fésüs, L.: Interleukin-6 released from differentiating human beige adipocytes improves browning.
Exp. Cell Res. 377 (1-2), 47-55, 2019.

Kovács, P., Csonka, T., Kovács, T., Sári, Z., Ujlaki, G., Sipos, A., Karányi, Z., Szeőcs, D., Hegedűs, C., Uray, K., Jankó, L., Kiss, M., Kiss, B., Laoui, D., Virág, L., Méhes, G., Bai, P., Mikó, E.: Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer.
Cancers (Basel). 11 1-31, 2019.

Mikó, E., Kovács, T., Sebő, É., Tóth, J., Csonka, T., Ujlaki, G., Sipos, A., Szabó, J., Méhes, G., Bai, P.: Microbiome-Microbial Metabolome-Cancer Cell Interactions in Breast Cancer-Familiar, but Unexplored.
Cells. 8 (4), 1-33, 2019.

Abdelwahab, E., Pal, S., Kvell, K., Sárosi, V., Bai, P., Rue, R., Krymskaya, V., McPhail, D., Porter, A., Pongrácz, J.: Mitochondrial dysfunction is a key determinant of the rare disease lymphangioleiomyomatosis and provides a novel therapeutic target.
Oncogene. 38 3093-3101, 2019.

Nagy, L., Rauch, B., Balla, N., Ujlaki, G., Kis, G., Omar, A., Kristóf, E., Sipos, A., Antal, M., Tóth, A., Debreceni, T., Horváth, A., Maros, T., Csizmadia, P., Szerafin, T., Bai, P.: Olaparib induces browning of in vitro cultures of human primary white adipocytes.
Biochem. Pharmacol. 167 76-85, 2019.

Nogales, C., Frijhoff, J., Thoenges, D., Sessions, R., Sickmann, A., Nedvetskaya, T., Ibarra-Alvarado, C., Schmitz, V., Rösen, P., Goedecke, A., Jovanovic, A., Perlman, D., Klinke, A., Baldus, S., Casas, A., Bai, P., Szabó, C., Feelisch, M., Schmidt, H.: Protein nitration is a physiological regulator of cardiac lactate dehydrogenase active site loop mobility and activity.
bioxiv.org 2019 1-34, 2019.

Vida, A., Kardos, G., Kovács, T., Bodrogi, B., Bai, P.: Deletion of poly(ADP?ribose) polymerase-1 changes the composition of the microbiome in the gut.
Mol. Med. Rep. 18 (5), 4335-4341, 2018.

Simon, Á., Németh, J., Jávor, A., Komlósi, I., Bai, P., Oláh, J., Juhász, B., Kiss, R., Szilvássy, Z., Czeglédi, L.: Feeding state and age dependent changes in melanin-concentrating hormone expression in the hypothalamus of broiler chickens.
Acta Biochim. Pol. 65 (2), 251-258, 2018.

Nagy, L., Márton, J., Vida, A., Kis, G., Bokor, É., Kun, S., Gönczi, M., Docsa, T., Tóth, A., Antal, M., Gergely, P., Csóka, B., Pacher, P., Somsák, L., Bai, P.: Glycogen phosphorylase inhibition improves beta cell function.
Br. J. Pharmacol. 175 (2), 301-319, 2018.

Mikó, E., Vida, A., Kovács, T., Ujlaki, G., Trencsényi, G., Márton, J., Sári, Z., Kovács, P., Boratkó, A., Hujber, Z., Csonka, T., Antal-Szalmás, P., Watanabe, M., Gombos, I., Csóka, B., Kiss, B., Vígh, L., Szabó, J., Méhes, G., Sebestyén, A., Goedert, J., Bai, P.: Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness.
Biochim. Biophys. Acta Bioenerg. 1859 (9), 958-974, 2018.

Bai, P., Nagy, L., Abdul-Rahman, O., Rauch, B., Balla, N., Kristóf, E., Tóth, A., Szerafin, T.: NAD+ homeostasis plays role in mitochondrial biogenesis during beige adipocyte differentiation.
Biochim. Biophys. Acta. Bioenerg. 1859 e36, 2018.

Márton, J., Fodor, T., Nagy, L., Vida, A., Kis, G., Brunyánszki, A., Antal, M., Lüscher, B., Bai, P.: PARP10 (ARTD10) modulates mitochondrial function.
PLoS One. 13 (1), e0187789, 2018.

Márton, J., Péter, M., Balogh, G., Bódi, B., Vida, A., Szántó, M., Bojcsuk, D., Jankó, L., Bhattoa, H., Gombos, I., Uray, K., Horváth, I., Török, Z., Bálint, B., Papp, Z., Vígh, L., Bai, P.: Poly(ADP-ribose) polymerase-2 is a lipid-modulated modulator of muscular lipid homeostasis.
Biochim. Biophys. Acta. Mol. Cell Biol. Lipids. 1863 (11), 1399-1412, 2018.

Simon, Á., Jávor, A., Bai, P., Oláh, J., Czeglédi, L.: Reference gene selection for reverse transcription quantitative polymerase chain reaction in chicken hypothalamus under different feeding status.
J. Anim. Physiol. Anim. Nutr. 102 (1), 286-296, 2018.

Mádi, A., Cuaranta-Monroy, I., Lénárt, K., Pap, A., Mezei, Z., Kristóf, E., Oláh, A., Vámosi, G., Bacsó, Z., Bai, P., Fésüs, L.: Browning deficiency and low mobilization of fatty acids in gonadal white adipose tissue leads to decreased cold-tolerance of transglutaminase 2 knock-out mice.
Biochim. Biophys. Acta. Mol. Cell Biol. Lipids. 1862 (12), 1575-1586, 2017.

Trencsényi, G., Dénes, N., Nagy, G., Kis, A., Vida, A., Farkas, F., Péli-Szabó, J., Kovács, T., Berényi, E., Garai, I., Bai, P., Hunyadi, J., Kertész, I.: Comparative preclinical evaluation of 68Ga-NODAGA and 68Ga-HBED-CC conjugated procainamide in melanoma imaging.
J. Pharmaceut. Biomed. Anal. 139 54-64, 2017.

Kertész, I., Vida, A., Nagy, G., Emri, M., Farkas, A., Kis, A., Angyal, J., Dénes, N., Péli-Szabó, J., Kovács, T., Bai, P., Trencsényi, G.: In Vivo Imaging of Experimental Melanoma Tumors Using The Novel Radiotracer 68Ga-NODAGA-Procainamide (PCA).
J. Cancer. 8 (5), 774-785, 2017.

Vida, A., Márton, J., Mikó, E., Bai, P.: Metabolic roles of poly(ADP-ribose) polymerases.
Semin. Cell Dev. Biol. 63 135-143, 2017.

Mukhopadhyay, P., Horváth, B., Rajesh, M., Varga, Z., Gariani, K., Ryu, D., Cao, Z., Holovac, E., Park, O., Zhou, Z., Xu, M., Wang, W., Godlewski, G., Pálóczi, J., Németh, B., Persidsky, Y., Liaudet, L., Haskó, G., Bai, P., Boulares, A., Auwerx, J., Gao, B., Pacher, P.: PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis.
J. Hepatol. 66 (3), 589-600, 2017.

Nagy, G., Dénes, N., Kis, A., Péli-Szabó, J., Berényi, E., Garai, I., Bai, P., Hajdu, I., Szikra, D., Trencsényi, G.: Preclinical evaluation of melanocortin-1 receptor (MC1-R) specific 68 Ga- and 44 Sc-labeled DOTA-NAPamide in melanoma imaging.
Eur. J. Pharm. Sci. 106 336-344, 2017.

Gönczi, M., Nagy, D., Bai, P., Pál, B., Kis, G., Antal, M., Csernoch, L.: Role of TASK-3 channels in the mitochondria of melanoma cells.
Acta Physiol. 221 130, 2017.

Iván, J., Major, E., Sipos, A., Kovács, K., Horváth, D., Tamás, I., Bai, P., Dombrádi, V., Lontay, B.: The Short-Chain Fatty Acid Propionate Inhibits Adipogenic Differentiation of Human Chorion-Derived Mesenchymal Stem Cells Through the Free Fatty Acid Receptor 2.
Stem Cells Dev. 26 (23), 1724-1733, 2017.

Trencsényi, G., Nagy, G., Vida, A., Dénes, N., Péli-Szabó, J., Kovács, T., Garai, I., Bai, P., Varga, J., Kertész, I.: Comparative in vitro and in vivo studies of Ga-68-labeled melanin-specific Procainamide (PCA) using different chelators.
Eur. J. Nucl. Med. Mol. Imaging. 43 (Suppl.), S453, 2016.

Trencsényi, G., Nagy, G., Vida, A., Angyal, J., Dénes, N., Péli-Szabó, J., Kovács, T., Garai, I., Bai, P., Kertész, I.: Investigation of experimental melanoma tumors using the novel melanin specific radiotracer Ga-68-NODAGA-Procainamide (PCA).
Eur. J. Nucl. Med. Mol. Imaging. 43 (Suppl.), S452-S453, 2016.