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Docsa Tibor
Docsa Tibor
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Department of Medical Chemistry
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Name:
Docsa Tibor
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Profession:
chemist, biochemist
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Uploaded publications:
70
Publications in DEA:
70
OA:
35
Date range:
1999-2024
2024
Homolya, L.
,
Mathomes, R.
,
Varga, L.
,
Docsa, T.
,
Juhász, L.
,
Hayes, J.
,
Somsák, L.
:
Synthesis, in silico and kinetics evaluation of N-(beta-D-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N-(beta-D-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as glycogen phosphorylase inhibitors
.
Int. J. Mol. Sci.
25 (9), 1-21, 2024.
Journal metrics:
Q2
Catalysis (2023)
Q1
Computer Science Applications (2023)
D1
Inorganic Chemistry (2023)
Q1
Medicine (miscellaneous) (2023)
Q2
Molecular Biology (2023)
D1
Organic Chemistry (2023)
Q1
Physical and Theoretical Chemistry (2023)
D1
Spectroscopy (2023)
2023
Kun, S.
,
Mathomes, R.
,
Docsa, T.
,
Somsák, L.
,
Hayes, J.
:
Design and Synthesis of 3-(β-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential
.
Molecules.
28 (7), 1-19, 2023.
Journal metrics:
Q1
Analytical Chemistry
Q1
Chemistry (miscellaneous)
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Q2
Physical and Theoretical Chemistry
Kola, J.
,
Docsa, T.
,
Uray, K.
:
Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract
.
Int. J. Mol. Sci.
24 (1), 1-12, 2023.
Journal metrics:
Q2
Catalysis
Q1
Computer Science Applications
D1
Inorganic Chemistry
Q1
Medicine (miscellaneous)
Q2
Molecular Biology
D1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
D1
Spectroscopy
Kola, J.
,
Turarova, B.
,
Csige, D.
,
Sipos, Á.
,
Varga, L.
,
Gergely, B.
,
Refai, F.
,
Uray, I.
,
Docsa, T.
,
Uray, K.
:
Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity
.
Molecules.
28 (11), 1-14, 2023.
Journal metrics:
Q1
Analytical Chemistry
Q1
Chemistry (miscellaneous)
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Q2
Physical and Theoretical Chemistry
2022
Docsa, T.
,
Sipos, Á.
,
Cox, C.
,
Uray, K.
:
The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders
.
Int. J. Mol. Sci.
23 (13), 1-22, 2022.
Journal metrics:
Q2
Catalysis
Q1
Computer Science Applications
D1
Inorganic Chemistry
Q1
Medicine (miscellaneous)
Q2
Molecular Biology
Q1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
D1
Spectroscopy
2021
Sipos, Á.
,
Szennyes, E.
,
Hajnal, É.
,
Kun, S.
,
Szabó, E.
,
Uray, K.
,
Somsák, L.
,
Docsa, T.
,
Bokor, É.
:
Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors
.
Pharmaceuticals.
14 (4), 1-27, 2021.
Journal metrics:
Q1
Drug Discovery
Q2
Molecular Medicine
Q1
Pharmaceutical Science
2020
Docsa, T.
,
Bhattarai, D.
,
Sipos, Á.
,
Wade, C.
,
Cox, C.
,
Uray, K.
:
CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity
.
Neurogastroenterol. Motil.
32 (3), 1-12, 2020.
Journal metrics:
Q2
Endocrine and Autonomic Systems
Q1
Gastroenterology
Q1
Physiology
Goyard, D.
,
Kónya, B.
,
Czifrák, K.
,
Larini, P.
,
Demontrond, F.
,
Leroy, J.
,
Balzarin, S.
,
Tournier, M.
,
Tousch, D.
,
Petit, P.
,
Duret, C.
,
Maurel, P.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
,
Praly, J.
,
Azay-Milhau, J.
,
Vidal, S.
:
Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition
.
Org. Biomol. Chem.
18 (5), 931-940, 2020.
Journal metrics:
Q2
Biochemistry
Q1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
Nagy, L.
,
Béke, F.
,
Juhász, L.
,
Kovács, T.
,
Juhász-Tóth, É.
,
Docsa, T.
,
Tóth, A.
,
Gergely, P.
,
Somsák, L.
,
Bai, P.
:
Glycogen phosphorylase inhibitor, 2,3-bis[(2E)-3-(4-hydroxyphenyl)prop-2-enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells
.
PLoS One.
15 (9), 1-15, 2020.
Journal metrics:
D1
Multidisciplinary
2019
Kun, S.
,
Kánya, N.
,
Galó, N.
,
Páhi, A.
,
Mándi, A.
,
Kurtán, T.
,
Makleit, P.
,
Veres, S.
,
Sipos, Á.
,
Docsa, T.
,
Somsák, L.
:
Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition
.
J. Agric. Food Chem.
67 (24), 6884-6891, 2019.
Journal metrics:
Q1
Agricultural and Biological Sciences (miscellaneous)
Q1
Chemistry (miscellaneous)
Szabó, E.
,
Kyriakis, E.
,
Psarra, A.
,
Karra, A.
,
Sipos, Á.
,
Docsa, T.
,
Stravodimos, G.
,
Katsidou, E.
,
Skamnaki, V.
,
Liggri, P.
,
Zographos, S.
,
Mándi, A.
,
Király, S.
,
Kurtán, T.
,
Leonidas, D.
,
Somsák, L.
:
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography
.
J. Med. Chem.
62 (13), 6116-6136, 2019.
Journal metrics:
D1
Drug Discovery
Q1
Molecular Medicine
Barr, D.
,
Szennyes, E.
,
Bokor, É.
,
Al-Oanzi, Z.
,
Moffatt, C.
,
Kun, S.
,
Docsa, T.
,
Sipos, Á.
,
Davies, M.
,
Mathomes, R.
,
Snape, T.
,
Agius, L.
,
Somsák, L.
,
Hayes, J.
:
Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies
.
ACS Chem. Biol.
14 (7), 1460-1470, 2019.
Journal metrics:
Q1
Biochemistry
D1
Medicine (miscellaneous)
Q1
Molecular Medicine
Szennyes, E.
,
Bokor, É.
,
Docsa, T.
,
Sipos, Á.
,
Somsák, L.
:
Synthesis of C-β-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase
.
Carbohydr. Res.
472 33-41, 2019.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
2018
Kun, S.
,
Begum, J.
,
Kyriakis, E.
,
Stamati, E.
,
Barkas, T.
,
Szennyes, E.
,
Bokor, É.
,
Szabó, E.
,
Stravodimos, G.
,
Sipos, Á.
,
Docsa, T.
,
Gergely, P.
,
Moffatt, C.
,
Patraskaki, M.
,
Kokolaki, M.
,
Gkerdi, A.
,
Skamnaki, V.
,
Leonidas, D.
,
Somsák, L.
,
Hayes, J.
:
A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors
.
Eur. J. Med. Chem.
147 266-278, 2018.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
Nagy, L.
,
Márton, J.
,
Vida, A.
,
Kis, G.
,
Bokor, É.
,
Kun, S.
,
Gönczi, M.
,
Docsa, T.
,
Tóth, A.
,
Antal, M.
,
Gergely, P.
,
Csóka, B.
,
Pacher, P.
,
Somsák, L.
,
Bai, P.
:
Glycogen phosphorylase inhibition improves beta cell function
.
Br. J. Pharmacol.
175 (2), 301-319, 2018.
Journal metrics:
D1
Pharmacology
Kun, S.
,
Bokor, É.
,
Sipos, Á.
,
Docsa, T.
,
Somsák, L.
:
Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase
.
Molecules.
23 (3), 1-17, 2018.
Journal metrics:
Q2
Analytical Chemistry
Q1
Chemistry (miscellaneous)
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Q2
Physical and Theoretical Chemistry
Szennyes, E.
,
Bokor, É.
,
Langer, P.
,
Gyémánt, G.
,
Docsa, T.
,
Sipos, Á.
,
Somsák, L.
:
The first general synthesis of 2-C-(beta-D-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes
.
New J. Chem.
42 (21), 17439-17446, 2018.
Journal metrics:
Q3
Catalysis
Q2
Chemistry (miscellaneous)
Q1
Materials Chemistry
2017
Bokor, É.
,
Kyriakis, E.
,
Solovou, T.
,
Koppány, C.
,
Kantsadi, A.
,
Szabó, E.
,
Szakács, A.
,
Stravodimos, G.
,
Docsa, T.
,
Skamnaki, V.
,
Zographos, S.
,
Gergely, P.
,
Leonidas, D.
,
Somsák, L.
:
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study
.
J. Med. Chem.
60 (22), 9251-9262, 2017.
Journal metrics:
D1
Drug Discovery
Q1
Molecular Medicine
2016
Bokor, É.
,
Széles, Z.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase
.
Carbohydr. Res.
429 128-134, 2016.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Goyard, D.
,
Kónya, B.
,
Chajistamatiou, A.
,
Chrysina, E.
,
Leroy, J.
,
Balzarin, S.
,
Tournier, M.
,
Tousch, D.
,
Petit, P.
,
Duret, C.
,
Maurel, P.
,
Somsák, L.
,
Docsa, T.
,
Gergely, P.
,
Praly, J.
,
Azay-Milhau, J.
,
Vidal, S.
:
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition
.
Eur. J. Med. Chem.
108 444-454, 2016.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
Szennyes, E.
,
Bokor, É.
,
Batta, G.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Improved preparation of 4(5)-aryl-2-(β-D-glucopyranosyl)-imidazoles, the most efficient glucose analogue inhibitors of glycogen phosphorylase
.
RSC Adv.
6 (97), 94787-94794, 2016.
Journal metrics:
Q1
Chemical Engineering (miscellaneous)
Q1
Chemistry (miscellaneous)
Petrušová, M.
,
Smrtičová, H.
,
Pribulová, B.
,
Vlčková, S.
,
Uhliariková, I.
,
Docsa, T.
,
Somsák, L.
,
Petruš, L.
:
One pot InCl3-catalyzed synthesis of 1-glycosylmethyl-1H-imidazoles
.
Tetrahedron.
72 (17), 2116-2121, 2016.
Journal metrics:
Q2
Biochemistry
Q2
Drug Discovery
Q2
Organic Chemistry
Kantsadi, A.
,
Bokor, É.
,
Kun, S.
,
Stravodimos, G.
,
Chatzileontiadou, D.
,
Leonidas, D.
,
Juhász-Tóth, É.
,
Szakács, A.
,
Batta, G.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase
.
Eur. J. Med. Chem.
123 737-745, 2016.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
2015
Donnier-Maréchal, M.
,
Goyard, D.
,
Folliard, V.
,
Docsa, T.
,
Gergely, P.
,
Praly, J.
,
Vidal, S.
:
3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors
.
Beilstein J. Org. Chem.
11 499-503, 2015.
Journal metrics:
Q1
Organic Chemistry
Bokor, É.
,
Kun, S.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase
.
ACS Med. Chem. Lett.
6 1215-1219, 2015.
Journal metrics:
Q2
Biochemistry
Q1
Drug Discovery
Q1
Organic Chemistry
2024
Homolya, L.
,
Mathomes, R.
,
Varga, L.
,
Docsa, T.
,
Juhász, L.
,
Hayes, J.
,
Somsák, L.
:
Synthesis, in silico and kinetics evaluation of N-(beta-D-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N-(beta-D-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as glycogen phosphorylase inhibitors
.
Int. J. Mol. Sci.
25 (9), 1-21, 2024.
Journal metrics:
Q2
Catalysis (2023)
Q1
Computer Science Applications (2023)
D1
Inorganic Chemistry (2023)
Q1
Medicine (miscellaneous) (2023)
Q2
Molecular Biology (2023)
D1
Organic Chemistry (2023)
Q1
Physical and Theoretical Chemistry (2023)
D1
Spectroscopy (2023)
2023
Kun, S.
,
Mathomes, R.
,
Docsa, T.
,
Somsák, L.
,
Hayes, J.
:
Design and Synthesis of 3-(β-D-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential
.
Molecules.
28 (7), 1-19, 2023.
Journal metrics:
Q1
Analytical Chemistry
Q1
Chemistry (miscellaneous)
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Q2
Physical and Theoretical Chemistry
Kola, J.
,
Docsa, T.
,
Uray, K.
:
Mechanosensing in the Physiology and Pathology of the Gastrointestinal Tract
.
Int. J. Mol. Sci.
24 (1), 1-12, 2023.
Journal metrics:
Q2
Catalysis
Q1
Computer Science Applications
D1
Inorganic Chemistry
Q1
Medicine (miscellaneous)
Q2
Molecular Biology
D1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
D1
Spectroscopy
Kola, J.
,
Turarova, B.
,
Csige, D.
,
Sipos, Á.
,
Varga, L.
,
Gergely, B.
,
Refai, F.
,
Uray, I.
,
Docsa, T.
,
Uray, K.
:
Stretch-Induced Down-Regulation of HCN2 Suppresses Contractile Activity
.
Molecules.
28 (11), 1-14, 2023.
Journal metrics:
Q1
Analytical Chemistry
Q1
Chemistry (miscellaneous)
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Q2
Physical and Theoretical Chemistry
2022
Docsa, T.
,
Sipos, Á.
,
Cox, C.
,
Uray, K.
:
The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders
.
Int. J. Mol. Sci.
23 (13), 1-22, 2022.
Journal metrics:
Q2
Catalysis
Q1
Computer Science Applications
D1
Inorganic Chemistry
Q1
Medicine (miscellaneous)
Q2
Molecular Biology
Q1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
D1
Spectroscopy
2021
Sipos, Á.
,
Szennyes, E.
,
Hajnal, É.
,
Kun, S.
,
Szabó, E.
,
Uray, K.
,
Somsák, L.
,
Docsa, T.
,
Bokor, É.
:
Dual-Target Compounds against Type 2 Diabetes Mellitus: proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors
.
Pharmaceuticals.
14 (4), 1-27, 2021.
Journal metrics:
Q1
Drug Discovery
Q2
Molecular Medicine
Q1
Pharmaceutical Science
2020
Docsa, T.
,
Bhattarai, D.
,
Sipos, Á.
,
Wade, C.
,
Cox, C.
,
Uray, K.
:
CXCL1 is upregulated during the development of ileus resulting in decreased intestinal contractile activity
.
Neurogastroenterol. Motil.
32 (3), 1-12, 2020.
Journal metrics:
Q2
Endocrine and Autonomic Systems
Q1
Gastroenterology
Q1
Physiology
Goyard, D.
,
Kónya, B.
,
Czifrák, K.
,
Larini, P.
,
Demontrond, F.
,
Leroy, J.
,
Balzarin, S.
,
Tournier, M.
,
Tousch, D.
,
Petit, P.
,
Duret, C.
,
Maurel, P.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
,
Praly, J.
,
Azay-Milhau, J.
,
Vidal, S.
:
Glucose-based spiro-oxathiazoles as in vivo anti-hyperglycemic agents through glycogen phosphorylase inhibition
.
Org. Biomol. Chem.
18 (5), 931-940, 2020.
Journal metrics:
Q2
Biochemistry
Q1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
Nagy, L.
,
Béke, F.
,
Juhász, L.
,
Kovács, T.
,
Juhász-Tóth, É.
,
Docsa, T.
,
Tóth, A.
,
Gergely, P.
,
Somsák, L.
,
Bai, P.
:
Glycogen phosphorylase inhibitor, 2,3-bis[(2E)-3-(4-hydroxyphenyl)prop-2-enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells
.
PLoS One.
15 (9), 1-15, 2020.
Journal metrics:
D1
Multidisciplinary
2019
Kun, S.
,
Kánya, N.
,
Galó, N.
,
Páhi, A.
,
Mándi, A.
,
Kurtán, T.
,
Makleit, P.
,
Veres, S.
,
Sipos, Á.
,
Docsa, T.
,
Somsák, L.
:
Glucopyranosylidene-spiro-benzo[b][1,4]oxazinones and -benzo[b][1,4]thiazinones: Synthesis and Investigation of Their Effects on Glycogen Phosphorylase and Plant Growth Inhibition
.
J. Agric. Food Chem.
67 (24), 6884-6891, 2019.
Journal metrics:
Q1
Agricultural and Biological Sciences (miscellaneous)
Q1
Chemistry (miscellaneous)
Szabó, E.
,
Kyriakis, E.
,
Psarra, A.
,
Karra, A.
,
Sipos, Á.
,
Docsa, T.
,
Stravodimos, G.
,
Katsidou, E.
,
Skamnaki, V.
,
Liggri, P.
,
Zographos, S.
,
Mándi, A.
,
Király, S.
,
Kurtán, T.
,
Leonidas, D.
,
Somsák, L.
:
Glucopyranosylidene-spiro-imidazolinones, a New Ring System: Synthesis and Evaluation as Glycogen Phosphorylase Inhibitors by Enzyme Kinetics and X-ray Crystallography
.
J. Med. Chem.
62 (13), 6116-6136, 2019.
Journal metrics:
D1
Drug Discovery
Q1
Molecular Medicine
Barr, D.
,
Szennyes, E.
,
Bokor, É.
,
Al-Oanzi, Z.
,
Moffatt, C.
,
Kun, S.
,
Docsa, T.
,
Sipos, Á.
,
Davies, M.
,
Mathomes, R.
,
Snape, T.
,
Agius, L.
,
Somsák, L.
,
Hayes, J.
:
Identification of C-[béta]-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: in Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies
.
ACS Chem. Biol.
14 (7), 1460-1470, 2019.
Journal metrics:
Q1
Biochemistry
D1
Medicine (miscellaneous)
Q1
Molecular Medicine
Szennyes, E.
,
Bokor, É.
,
Docsa, T.
,
Sipos, Á.
,
Somsák, L.
:
Synthesis of C-β-D-glucopyranosyl derivatives of some fused azoles for the inhibition of glycogen phosphorylase
.
Carbohydr. Res.
472 33-41, 2019.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
2018
Kun, S.
,
Begum, J.
,
Kyriakis, E.
,
Stamati, E.
,
Barkas, T.
,
Szennyes, E.
,
Bokor, É.
,
Szabó, E.
,
Stravodimos, G.
,
Sipos, Á.
,
Docsa, T.
,
Gergely, P.
,
Moffatt, C.
,
Patraskaki, M.
,
Kokolaki, M.
,
Gkerdi, A.
,
Skamnaki, V.
,
Leonidas, D.
,
Somsák, L.
,
Hayes, J.
:
A multidisciplinary study of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4-triazole derivatives as glycogen phosphorylase inhibitors: computation, synthesis, crystallography and kinetics reveal new potent inhibitors
.
Eur. J. Med. Chem.
147 266-278, 2018.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
Nagy, L.
,
Márton, J.
,
Vida, A.
,
Kis, G.
,
Bokor, É.
,
Kun, S.
,
Gönczi, M.
,
Docsa, T.
,
Tóth, A.
,
Antal, M.
,
Gergely, P.
,
Csóka, B.
,
Pacher, P.
,
Somsák, L.
,
Bai, P.
:
Glycogen phosphorylase inhibition improves beta cell function
.
Br. J. Pharmacol.
175 (2), 301-319, 2018.
Journal metrics:
D1
Pharmacology
Kun, S.
,
Bokor, É.
,
Sipos, Á.
,
Docsa, T.
,
Somsák, L.
:
Synthesis of New C- and N-beta-D-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase
.
Molecules.
23 (3), 1-17, 2018.
Journal metrics:
Q2
Analytical Chemistry
Q1
Chemistry (miscellaneous)
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Q2
Physical and Theoretical Chemistry
Szennyes, E.
,
Bokor, É.
,
Langer, P.
,
Gyémánt, G.
,
Docsa, T.
,
Sipos, Á.
,
Somsák, L.
:
The first general synthesis of 2-C-(beta-D-glycopyranosyl)pyrimidines and their evaluation as inhibitors of some glycoenzymes
.
New J. Chem.
42 (21), 17439-17446, 2018.
Journal metrics:
Q3
Catalysis
Q2
Chemistry (miscellaneous)
Q1
Materials Chemistry
2017
Bokor, É.
,
Kyriakis, E.
,
Solovou, T.
,
Koppány, C.
,
Kantsadi, A.
,
Szabó, E.
,
Szakács, A.
,
Stravodimos, G.
,
Docsa, T.
,
Skamnaki, V.
,
Zographos, S.
,
Gergely, P.
,
Leonidas, D.
,
Somsák, L.
:
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study
.
J. Med. Chem.
60 (22), 9251-9262, 2017.
Journal metrics:
D1
Drug Discovery
Q1
Molecular Medicine
2016
Bokor, É.
,
Széles, Z.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
C-Glucopyranosyl-1,2,4-triazol-5-ones: synthesis and inhibition of glycogen phosphorylase
.
Carbohydr. Res.
429 128-134, 2016.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Goyard, D.
,
Kónya, B.
,
Chajistamatiou, A.
,
Chrysina, E.
,
Leroy, J.
,
Balzarin, S.
,
Tournier, M.
,
Tousch, D.
,
Petit, P.
,
Duret, C.
,
Maurel, P.
,
Somsák, L.
,
Docsa, T.
,
Gergely, P.
,
Praly, J.
,
Azay-Milhau, J.
,
Vidal, S.
:
Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition
.
Eur. J. Med. Chem.
108 444-454, 2016.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
Szennyes, E.
,
Bokor, É.
,
Batta, G.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Improved preparation of 4(5)-aryl-2-(β-D-glucopyranosyl)-imidazoles, the most efficient glucose analogue inhibitors of glycogen phosphorylase
.
RSC Adv.
6 (97), 94787-94794, 2016.
Journal metrics:
Q1
Chemical Engineering (miscellaneous)
Q1
Chemistry (miscellaneous)
Petrušová, M.
,
Smrtičová, H.
,
Pribulová, B.
,
Vlčková, S.
,
Uhliariková, I.
,
Docsa, T.
,
Somsák, L.
,
Petruš, L.
:
One pot InCl3-catalyzed synthesis of 1-glycosylmethyl-1H-imidazoles
.
Tetrahedron.
72 (17), 2116-2121, 2016.
Journal metrics:
Q2
Biochemistry
Q2
Drug Discovery
Q2
Organic Chemistry
Kantsadi, A.
,
Bokor, É.
,
Kun, S.
,
Stravodimos, G.
,
Chatzileontiadou, D.
,
Leonidas, D.
,
Juhász-Tóth, É.
,
Szakács, A.
,
Batta, G.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthetic, enzyme kinetic, and protein crystallographic studies of C-[béta]-D-glucopyranosyl pyrroles and imidazoles reveal and explain low nanomolar inhibition of human liver glycogen phosphorylase
.
Eur. J. Med. Chem.
123 737-745, 2016.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
2015
Donnier-Maréchal, M.
,
Goyard, D.
,
Folliard, V.
,
Docsa, T.
,
Gergely, P.
,
Praly, J.
,
Vidal, S.
:
3-Glucosylated 5-amino-1,2,4-oxadiazoles: synthesis and evaluation as glycogen phosphorylase inhibitors
.
Beilstein J. Org. Chem.
11 499-503, 2015.
Journal metrics:
Q1
Organic Chemistry
Bokor, É.
,
Kun, S.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
4(5)-Aryl-2-C-glucopyranosyl-imidazoles as New Nanomolar Glucose Analogue Inhibitors of Glycogen Phosphorylase
.
ACS Med. Chem. Lett.
6 1215-1219, 2015.
Journal metrics:
Q2
Biochemistry
Q1
Drug Discovery
Q1
Organic Chemistry
Bokor, É.
,
Szennyes, E.
,
Csupász, T.
,
Tóth, N.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
C-(2-Deoxy-D-arabino-hex-1-enopyranosyl)-oxadiazoles: synthesis of possible isomers and their evaluation as glycogen phosphorylase inhibitors
.
Carbohydr. Res.
412 71-79, 2015.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Begum, J.
,
Varga, G.
,
Docsa, T.
,
Gergely, P.
,
Hayes, J.
,
Juhász, L.
,
Somsák, L.
:
Computationally motivated synthesis and enzyme kinetic evaluation of N-([beta]-D-glucopyranosyl)-1,2,4-triazolecarboxamides as glycogen phosphorylase inhibitors
.
Med. Chem. Commun.
6 (1), 80-89, 2015.
Journal metrics:
Q2
Biochemistry
Q1
Pharmaceutical Science
Docsa, T.
,
Marics, B.
,
Németh, J.
,
Hüse, C.
,
Somsák, L.
,
Gergely, P.
,
Peitl, B.
:
Insulin sensitivity is modified by a glycogen phosphorylase inhibitor: glucopyranosylidene-spiro-thiohydantoin in streptozotocin-induced diabetic rats
.
Curr. Top. Med. Chem.
15 (23), 2390-2394, 2015.
Journal metrics:
Q2
Drug Discovery
Q2
Medicine (miscellaneous)
Goyard, D.
,
Docsa, T.
,
Gergely, P.
,
Praly, J.
,
Vidal, S.
:
Synthesis of 4-amidomethyl-1-glucosyl-1,2,3-triazoles and evaluation as glycogen phosphorylase inhibitors
.
Carbohydr. Res.
402 245-251, 2015.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
2014
Czifrák, K.
,
Páhi, A.
,
Deák, S.
,
Kiss-Szikszai, A.
,
Kövér, K.
,
Docsa, T.
,
Gergely, P.
,
Alexacou, K.
,
Papakonstantinou, M.
,
Leonidas, D.
,
Zographos, S.
,
Chrysina, E.
,
Somsák, L.
:
Glucopyranosylidene-spiro-iminothiazolidinone, a New Bicyclic Ring System: Synthesis, Derivatization, and Evaluation for Inhibition of Glycogen Phosphorylase by Enzyme Kinetic and Crystallographic Methods
.
Bioorg. Med. Chem.
22 (15), 4028-4041, 2014.
Journal metrics:
Q2
Biochemistry
Q2
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
Q1
Pharmaceutical Science
Kun, S.
,
Bokor, É.
,
Varga, G.
,
Szőcs, B.
,
Páhi, A.
,
Czifrák, K.
,
Tóth, M.
,
Juhász, L.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
New synthesis of 3-(β-D-glucopyranosyl)-5-substituted-1,2,4- triazoles, nanomolar inhibitors of glycogen phosphorylase
.
Eur. J. Med. Chem.
76 567-579, 2014.
Journal metrics:
Q1
Drug Discovery
Q1
Medicine (miscellaneous)
Q1
Organic Chemistry
Q1
Pharmacology
Juhász, L.
,
Varga, G.
,
Sztankovics, A.
,
Béke, F.
,
Docsa, T.
,
Kiss-Szikszai, A.
,
Gergely, P.
,
Kóňa, J.
,
Tvaroška, I.
,
Somsák, L.
:
Structure-activity relationships of glycogen phosphorylase inhibitor FR258900 and its analogues: a combined synthetic, enzyme kinetics, and computational study
.
ChemPlusChem.
79 (11), 1558-1568, 2014.
Journal metrics:
Q1
Chemistry (miscellaneous)
Somsák, L.
,
Bokor, É.
,
Czibere, B.
,
Czifrák, K.
,
Koppány, C.
,
Kulcsár, L.
,
Kun, S.
,
Szilágyi, E.
,
Tóth, M.
,
Docsa, T.
,
Gergely, P.
:
Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase
.
Carbohydr. Res.
399 38-48, 2014.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
2013
Bokor, É.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
C-Glucopyranosyl-1,2,4-triazoles As New Potent Inhibitors of Glycogen Phosphorylase
.
ACS Med. Chem. Lett.
4 (7), 612-615, 2013.
Journal metrics:
Q1
Biochemistry
Q1
Drug Discovery
Q1
Organic Chemistry
Nagy, L.
,
Docsa, T.
,
Szántó, M.
,
Brunyánszki, A.
,
Hegedűs, C.
,
Márton, J.
,
Kónya, B.
,
Virág, L.
,
Somsák, L.
,
Gergely, P.
,
Bai, P.
:
Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N'-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism
.
PLoS One.
8 (7), e69420-, 2013.
Journal metrics:
D1
Agricultural and Biological Sciences (miscellaneous)
Q1
Biochemistry, Genetics and Molecular Biology (miscellaneous)
D1
Medicine (miscellaneous)
Polyák, M.
,
Varga, G.
,
Szilágyi, B.
,
Juhász, L.
,
Docsa, T.
,
Gergely, P.
,
Begum, J.
,
Hayes, J.
,
Somsák, L.
:
Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors
.
Bioorg. Med. Chem.
21 (18), 5738-5747, 2013.
Journal metrics:
Q2
Biochemistry
Q2
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
Q1
Pharmaceutical Science
Szőcs, B.
,
Tóth, M.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthesis of 2-(β-D-glucopyranosyl)-5-(substituted-amino)-1,3,4-oxa-and -thiadiazoles for the inhibition of glycogen phosphorylase
.
Carbohydr. Res.
381C 187-195, 2013.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Tóth, M.
,
Szőcs, B.
,
Kaszás, T.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase
.
Carbohydr. Res.
381C 196-204, 2013.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Bokor, É.
,
Szilágyi, E.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthesis of substituted 2-(β-d-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase
.
Carbohydr. Res.
381C 179-186, 2013.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Varga, G.
,
Docsa, T.
,
Gergely, P.
,
Juhász, L.
,
Somsák, L.
:
Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors
.
Bioorg. Med. Chem. Lett.
23 (6), 1789-1792, 2013.
Journal metrics:
Q2
Biochemistry
Q2
Clinical Biochemistry
Q2
Drug Discovery
Q3
Molecular Biology
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
2012
Nagy, V.
,
Felföldi, N.
,
Kónya, B.
,
Praly, J.
,
Docsa, T.
,
Gergely, P.
,
Chrysina, E.
,
Tiraidis, C.
,
Kosmopoulou, M.
,
Alexacou, K.
,
Konstantakaki, M.
,
Leonidas, D.
,
Zographos, S.
,
Oikonomakos, N.
,
Kozmon, S.
,
Tvaroška, I.
,
Somsák, L.
:
N-(4-Substituted-benzoyl)-N'-(beta-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods
.
Bioorg. Med. Chem.
20 (5), 1801-1816, 2012.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q2
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
D1
Pharmaceutical Science
Goyard, D.
,
Baron, M.
,
Skourti, P.
,
Chajistamatiou, A.
,
Docsa, T.
,
Gergely, P.
,
Chrysina, E.
,
Praly, J.
,
Vidal, S.
:
Synthesis of 1,2,3-triazoles from xylosyl and 5-thioxylosyl azides: evaluation of the xylose scaffold for the design of potential glycogen phosphorylase inhibitors
.
Carbohydr. Res.
364 28-40, 2012.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Kónya, B.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthesis of heterocyclic N-(beta-d-glucopyranosyl)carboxamides for inhibition of glycogen phosphorylase
.
Carbohydr. Res.
351 56-63, 2012.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
Tite, T.
,
Loic, T.
,
Docsa, T.
,
Gergely, P.
,
Kovensky, J.
,
Gueyrard, D.
,
Wadouachi, A.
:
Synthesis of N-aryl spiro-sulfamides as potential glycogen phosphorylase inhibitors
.
Tetrahedron Lett.
53 (8), 959-961, 2012.
Journal metrics:
Q2
Biochemistry
Q1
Drug Discovery
Q2
Organic Chemistry
2011
Docsa, T.
,
Czifrák, K.
,
Hüse, C.
,
Somsák, L.
,
Gergely, P.
:
Effect of glucopyranosylidene-spiro-thiohydantoin on glycogen metabolism in liver tissues of streptozotocin-induced and obese diabetic rats
.
Mol. Med. Rep.
4 (3), 477-481, 2011.
Journal metrics:
Q4
Biochemistry
Q4
Cancer Research
Q4
Genetics
Q4
Molecular Biology
Q4
Molecular Medicine
Q3
Oncology
Kun, S.
,
Nagy, G.
,
Tóth, M.
,
Czecze, L.
,
Van Nhien, A.
,
Docsa, T.
,
Gergely, P.
,
Charavgi, M.
,
Skourti, P.
,
Chrysina, E.
,
Patonay, T.
,
Somsák, L.
:
Synthesis of variously coupled conjugates of d-glucose, 1,3,4-oxadiazole, and 1,2,3-triazole for inhibition of glycogen phosphorylase
.
Carbohydr. Res.
346 (12), 1427-1438, 2011.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
2010
Czakó, Z.
,
Docsa, T.
,
Gergely, P.
,
Juhász, L.
,
Antus, S.
:
Synthesis and glycogen phosphorylase inhibitor activity of funtionalized 1,4-benzodioxanes
.
Pharmazie.
65 (4), 235-238, 2010.
Journal metrics:
Q2
Pharmaceutical Science
Bokor, É.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthesis of 1-(D-glucopyranosyl)-1,2,3-triazoles and their evaluation as glycogen phosphorylase inhibitors
.
Bioorg. Med. Chem.
18 (3), 1171-1180, 2010.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Cheng, K.
,
Liu, J.
,
Sun, H.
,
Bokor, É.
,
Czifrák, K.
,
Kónya, B.
,
Tóth, M.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Tethered derivatives of D-glucose and pentacyclic triterpenes for homo/heterobivalent inhibition of glycogen phosphorylase
.
New J. Chem.
34 1450-1464, 2010.
Journal metrics:
Q2
Catalysis
Q1
Chemistry (miscellaneous)
Q1
Materials Chemistry
2009
Nagy, V.
,
Benltifa, M.
,
Vidal, S.
,
Berzsényi, E.
,
Teilhet, C.
,
Czifrák, K.
,
Batta, G.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
,
Praly, J.
:
Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase
.
Bioorg. Med. Chem.
17 (15), 5696-5707, 2009.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
Q1
Pharmaceutical Science
Cecioni, S.
,
Argintaru, O.
,
Praly, J.
,
Vidal, S.
,
Docsa, T.
,
Gergely, P.
:
Probing multivalency for the inhibition of an enzyme: glycogen phosphorylase as a case study
.
New J. Chem.
33 (1), 148-156, 2009.
Journal metrics:
Q2
Catalysis
Q1
Chemistry (miscellaneous)
D1
Materials Chemistry
Czakó, Z.
,
Juhász, L.
,
Kenéz, Á.
,
Czifrák, K.
,
Somsák, L.
,
Docsa, T.
,
Gergely, P.
,
Antus, S.
:
Synthesis and glycogen phosphorylase inhibitory activity of N-(beta-D-glucopyranosyl)amides possessing 1,4-benzodioxane moiety
.
Bioorg. Med. Chem.
17 (18), 6738-6741, 2009.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
Q1
Pharmaceutical Science
Tóth, M.
,
Kun, S.
,
Bokor, É.
,
Benltifa, M.
,
Tallec, G.
,
Vidal, S.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
,
Praly, J.
:
Synthesis and structure-activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase
.
Bioorg. Med. Chem.
17 (13), 4773-4785, 2009.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
Q1
Pharmaceutical Science
2008
Bertus, P.
,
Szymoniak, J.
,
Jeanneau, E.
,
Docsa, T.
,
Gergely, P.
,
Praly, J.
,
Vidal, S.
:
Synthesis of a C-glucosylated cyclopropylamide and evaluation as a glycogen phosphorylase inhibitor
.
Bioorg. Med. Chem. Lett.
18 (17), 4774-4778, 2008.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q2
Molecular Biology
Q2
Molecular Medicine
Q1
Organic Chemistry
Q1
Pharmaceutical Science
2007
Juhász, L.
,
Docsa, T.
,
Brunyánszki, A.
,
Gergely, P.
,
Antus, S.
:
Synthesis and glycogen phosphorylase inhibitor activity of 2,3-dihydrobenzo[1,4]dioxin derivatives
.
Bioorg. Med. Chem.
15 (12), 4048-4056, 2007.
Journal metrics:
Q2
Biochemistry
Q2
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
2006
Anagnostou, E.
,
Kosmopoulou, M.
,
Chrysina, E.
,
Leonidas, D.
,
Hadjiloi, T.
,
Tiraidis, C.
,
Zographos, S.
,
Györgydeák, Z.
,
Somsák, L.
,
Docsa, T.
,
Gergely, P.
,
Kolisis, F.
,
Oikonomakos, G.
:
Crystallographic studies on two bioisosteric analogues, N-acetyl-beta-D-glucopyranosylamine and N-trifluoroacetyl-beta-D-glucopyranosylamine, potent inhibitors of muscle glycogen phosphorylase
.
Bioorg. Med. Chem.
14 (1), 181-189, 2006.
Journal metrics:
Q2
Biochemistry
Q2
Clinical Biochemistry
Q2
Drug Discovery
Q3
Molecular Biology
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
Benltifa, M.
,
Vidal, S.
,
Fenet, B.
,
Msaddek, M.
,
Goekjian, P.
,
Praly, J.
,
Brunyánszki, A.
,
Docsa, T.
,
Gergely, P.
:
In search of glycogen phosphorylase inhibitors: 5-substituted 3-C-glucopyranosyl-1,2,4-oxadiazoles from beta-D-glucopyranosyl cyanides upon cyclization of O-acylamidoxime intermediates
.
European J. Org. Chem.
2006 (18), 4242-4256, 2006.
Journal metrics:
Q1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
Czifrák, K.
,
Hadady, Z.
,
Docsa, T.
,
Gergely, P.
,
Schmidt, J.
,
Wessjohann, L.
,
Somsák, L.
:
Synthesis of N-(beta-D-glucopyranosyl) monoamides of dicarboxylic acids as potential inhibitors of glycogen phosphorylase
.
Carbohydr. Res.
341 (8), 947-956, 2006.
Journal metrics:
Q2
Analytical Chemistry
Q3
Biochemistry
Q2
Medicine (miscellaneous)
Q2
Organic Chemistry
2005
Chrysina, E.
,
Kosmopoulou, M.
,
Tiraidis, C.
,
Kardakaris, R.
,
Bischler, N.
,
Leonidas, D.
,
Hadady, Z.
,
Somsák, L.
,
Docsa, T.
,
Gergely, P.
,
Oikonomakos, N.
:
Kinetic and crystallographic studies on 2-(beta-D-glucopyranosyl)-5-methyl-1, 3, 4-oxadiazole, -benzothiazole, and -benzimidazole, inhibitors of muscle glycogen phosphorylase b. Evidence for a new binding site
.
Protein Sci.
14 (4), 873-888, 2005.
Journal metrics:
Q1
Biochemistry
D1
Medicine (miscellaneous)
Q1
Molecular Biology
Somsák, L.
,
Nagy, V.
,
Hadady, Z.
,
Felföldi, N.
,
Docsa, T.
,
Gergely, P.
:
Recent developments in the synthesis and evaluation of glucose analog inhibitors of glycogen phosphorylase as potential antidiabetic agents
.
In: Frontiers in Medicinal Chemistry - Online. Eds.: Allen B. Reitz, Atta-ur-Rahman, Bentham Science Publisher, Netherlands, 253-272, 2005.
2004
Györgydeák, Z.
,
Hadady, Z.
,
Felföldi, N.
,
Krakomperger, A.
,
Nagy, V.
,
Tóth, M.
,
Brunyánszki, A.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Synthesis of N-(beta-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-beta-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase
.
Bioorg. Med. Chem.
12 (18), 4861-4870, 2004.
Journal metrics:
Q2
Biochemistry
Q2
Clinical Biochemistry
Q2
Drug Discovery
Q3
Molecular Biology
Q3
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
2003
Chrysina, E.
,
Oikonomakos, N.
,
Zographos, S.
,
Kosmopoulou, M.
,
Bischler, N.
,
Leonidas, D.
,
Kovács, L.
,
Docsa, T.
,
Gergely, P.
,
Somsák, L.
:
Crystallographic studies on α- and β-D-glucopyranosyl formamide analogues, inhibitors of glycogen phosphorylase
.
Biocatal. Biotransform.
21 (4-5), 233-242, 2003.
Journal metrics:
Q3
Biochemistry
Q3
Biotechnology
Q4
Catalysis
Somsák, L.
,
Nagy, V.
,
Hadady, Z.
,
Docsa, T.
,
Gergely, P.
:
Glucose analog inhibitors of glycogen phosphorylases as potential antidiabetic agents: recent developments
.
Curr. Pharm. Des.
9 (15), 1177-1189, 2003.
Journal metrics:
Q1
Drug Discovery
Q1
Pharmacology
2002
Oikonomakos, N.
,
Kosmopoulou, M.
,
Zographos, S.
,
Leonidas, D.
,
Chrysina, E.
,
Somsák, L.
,
Nagy, V.
,
Praly, J.
,
Docsa, T.
,
Tóth, B.
,
Gergely, P.
:
Binding of N-acetyl-N'-β-D-glucopyranosyl urea and N-benzoyl-N'-β-D-glucopyranosyl urea to glycogen phosphorylase b: kinetic and crystallographic studies
.
Eur. J. Biochem.
269 (6), 1684-1696, 2002.
Oikonomakos, N.
,
Skamnaki, V.
,
Ősz, E.
,
Szilágyi, L.
,
Somsák, L.
,
Docsa, T.
,
Tóth, B.
,
Gergely, P.
:
Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B
.
Bioorg. Med. Chem.
10 (2), 261-268, 2002.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q2
Organic Chemistry
Q1
Pharmaceutical Science
2001
Docsa, T.
,
Somsák, L.
,
Tóth, B.
,
Gergely, P.
:
Effect of glucopyranosylidene-spiro-thiohydantoin on the enzymes of hepatic glycogen metabolism in rats
.
In: Protein Modules in Cellular Signalling. Ed.: by Ludwig Heilmeyer, Peter Friedrich, IOS Press, Amsterdam, 142-149, 2001. ISBN: 1586031805
Somsák, L.
,
Kovács, L.
,
Tóth, M.
,
Ősz, E.
,
Szilágyi, L.
,
Györgydeák, Z.
,
Dinya, Z.
,
Docsa, T.
,
Tóth, B.
,
Gergely, P.
:
Synthesis of and a comparative study on the inhibition of muscle and liver glycogen phosphorylases by epimeric pairs of D-Gluco- and D-Xylopyranosylidene-spiro-(thio)hydantoins and N-(D-Glucopyranosyl) amides
.
J. Med. Chem.
44 (17), 2843-2848, 2001.
Journal metrics:
D1
Drug Discovery
Q1
Molecular Medicine
2000
Somsák, L.
,
Nagy, V.
,
Docsa, T.
,
Tóth, B.
,
Gergely, P.
:
Gram-scale synthesis of a glucopyranosylidene-spiro-thiohydantoin and its effect on hepatic glycogen metabolism studied in vitro and in vivo
.
Tetrahedron Asymmetry.
11 405-408, 2000.
Journal metrics:
Q2
Catalysis
D1
Inorganic Chemistry
D1
Organic Chemistry
Q1
Physical and Theoretical Chemistry
Docsa, T.
,
Tar, K.
,
Tóth, B.
,
Somsák, L.
,
Gergely, P.
:
Regulation of hepatic glycogen metabolism by glycopyranosylidene-spiro-thiohydantoin
.
J. Physiol.-London.
5262000.
1999
Ősz, E.
,
Somsák, L.
,
Szilágyi, L.
,
Kovács, L.
,
Docsa, T.
,
Tóth, B.
,
Gergely, P.
:
Efficient inhibition of muscle and liver glycogen phosphorylases by a new glucopyranosylidene-spiro-thiohydantoin
.
Bioorg. Med. Chem. Lett.
9 (10), 1385-1390, 1999.
Journal metrics:
Q2
Biochemistry
Q1
Clinical Biochemistry
Q1
Drug Discovery
Q3
Molecular Biology
Q2
Molecular Medicine
Q2
Organic Chemistry
D1
Pharmaceutical Science
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Journals
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Bioorganic & Medicinal Chemistry (12)
Carbohydrate Research (12)
European Journal of Medicinal Chemistry (4)
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iDEa co-authors
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Praly, Jean-Pierre
(co-authored publications: 12)
Leonidas, Demetres D.
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(co-authored publications: 1)
Tóth Nóra
(co-authored publications: 1)
Turarova, Botagoz
(co-authored publications: 1)
Uhliariková, Iveta
(co-authored publications: 1)
Van Nhien, Albert Nguyen
(co-authored publications: 1)
Vlčková, Silvia
(co-authored publications: 1)
Wade, Charles E.
(co-authored publications: 1)
Wadouachi, Anne
(co-authored publications: 1)
Wessjohann, Ludger A.
(co-authored publications: 1)
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